Novel therapeutic approaches for non-small cell lung cancer: an updated view
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 29
Опубликована: Апрель 5, 2025
Non-small
cell
lung
cancer
(NSCLC)
continues
to
be
one
of
the
leading
causes
cancer-related
mortality
globally.
Most
patients
who
undergo
surgical
procedures
may
encounter
distant
metastasis
or
local
recurrence,
necessitating
supplementary
treatments
such
as
radiation
therapy,
chemotherapy,
targeted
therapy
adjuvant
alternatives.
Recent
advancements
in
molecular
biology
and
immunotherapy
have
paved
way
for
innovative
therapeutic
approaches
that
target
specific
genetic
mutations
promote
immune
response
against
tumor
cells.
This
review
explores
emerging
therapies,
including
therapies
tyrosine
kinase
inhibitors
(TKIs)
actionable
(e.g.,
EGFR,
ALK,
ROS1),
well
role
checkpoint
(ICIs)
employ
body's
system
combat
cancer.
Additionally,
we
discuss
potential
exosome
promising
nanotherapeutic
options
treatment
NSCLC.
study
attempts
provide
a
thorough
overview
changing
landscape
NSCLC
its
implications
enhancing
patient
outcomes
by
presenting
these
techniques.
Язык: Английский
Cell-based Immunotherapy in Esophageal Cancer
Journal of drug targeting,
Год журнала:
2025,
Номер
unknown, С. 1 - 19
Опубликована: Март 10, 2025
Esophageal
cancer
(EC)
is
among
the
most
common
illnesses
globally,
and
its
prognosis
unfavorable.
Surgery,
radiotherapy,
chemotherapy
are
primary
therapy
options
for
EC.
Despite
occasional
efficacy
of
these
traditional
treatment
modalities,
individuals
with
EC
remain
at
a
significant
risk
local
recurrence
metastasis.
Consequently,
innovative
efficacious
medicines
required.
In
recent
decades,
clinical
practice
has
effectively
implemented
cell
therapy,
which
includes
both
stem
non-stem
cell-based
approaches,
as
an
tumor
treatment,
offering
renewed
hope
to
patients
esophageal
squamous
carcinoma
(ESCC).
This
paper
examines
theoretical
framework
contemporary
advancements
in
We
further
described
current
studies
summarized
essential
data
related
survival
safety
assessments.
Язык: Английский
Sphingosine-1-Phosphate Metabolic Pathway in Cancer: Implications for Therapeutic Targets
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(3), С. 1056 - 1056
Опубликована: Янв. 26, 2025
Cancer
biology
revolves
around
understanding
how
cells
undergo
uncontrolled
proliferation
leading
to
the
formation
of
malignant
tumors.
Key
aspects
include
self-sufficiency
in
growth
signals,
lack
response
signals
inhibition,
evasion
apoptosis,
sustained
angiogenesis,
immune
response,
capacity
invade
and
metastasize,
alterations
cellular
metabolism.
A
vast
amount
research,
which
is
exponentially
growing,
over
past
few
decades
highlights
role
sphingolipids
cancer.
They
act
not
only
as
structural
membrane
components
but
also
bioactive
molecules
that
regulate
cell
fate
different
physio-pathological
conditions.
In
cancer,
sphingolipid
metabolism
dysregulated,
contributing
tumor
progression,
metastasis,
drug
resistance.
this
review,
we
outline
impact
sphingosine-1-phosphate
(S1P)
a
key
We
give
an
overview
its
summarizing
S1P
intracellular
extracellular
mediator
through
specific
plasma
receptors
cancers.
describe
previous
findings
on
disruption
balance
between
ceramide
(Cer)
common
cancer
can
contribute
tumorigenesis
resistance
chemotherapy.
finally
consider
potential
targeting
metabolic
pathways
well
transporters
promising
therapeutic
approach
treatments.
Язык: Английский
Plant Terpenoids in Combination with Conventional Therapeutics in Colorectal Cancer: A Promising Option
Current Oncology Reports,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 21, 2025
Язык: Английский
The effects of n-3 PUFAs on colorectal cancer carcinogenesis: comprehensive review
Food and Agricultural Immunology,
Год журнала:
2025,
Номер
36(1)
Опубликована: Май 15, 2025
Язык: Английский
Gut microbiome and Colorectal Cancer: from pathogenesis to treatment
Pathology - Research and Practice,
Год журнала:
2025,
Номер
271, С. 156034 - 156034
Опубликована: Май 21, 2025
Язык: Английский
Anti-infertility roles of flavonoids: insights into the female reproductive system
Molecular Biology Reports,
Год журнала:
2025,
Номер
52(1)
Опубликована: Май 22, 2025
Язык: Английский
Clostridium difficile as a potent trigger of colorectal carcinogenesis
Discover Oncology,
Год журнала:
2025,
Номер
16(1)
Опубликована: Май 24, 2025
Язык: Английский
Harnessing Stem Cells for Pediatric Respiratory Diseases: Potential and Clinical Translation
Fatemeh Alizadeh,
Sanaz Yasrebinia
Cell Biology International,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 30, 2025
ABSTRACT
Pediatric
respiratory
diseases,
ranging
from
acute
infections
to
chronic
lung
conditions,
pose
significant
morbidity
and
mortality
risks.
Current
treatment
approaches
focus
on
symptomatic
relief
rather
than
regenerative
solutions.
Stem
cell
therapy
has
emerged
as
a
promising
alternative
due
its
potential
for
immunomodulation,
inflammation
reduction,
tissue
repair.
Mesenchymal
stem
cells
(MSCs)
induced
pluripotent
(iPSCs)
have
been
extensively
studied
their
properties,
with
MSC‐derived
extracellular
vesicles
showing
cell‐free
therapeutic
approach.
Despite
preclinical
early
clinical
findings,
challenges
such
immune
rejection,
ethical
concerns,
the
need
standardized
protocols
hinder
translation.
This
review
examines
recent
advancements
in
pediatric
outlining
potential,
limitations,
future
research
directions.
Язык: Английский