Targeting toll-like receptors: unveiling potential therapeutic strategies for deep vein thrombosis DOI Creative Commons
Wei Shao, Zilong Wang, Jian Wu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Май 29, 2025

Deep vein thrombosis (DVT) is a complex multifactorial vascular disease characterized by abnormal blood stasis and coagulation within the deep veins, primarily occurring in lower limbs. This pathological condition not only causes local circulatory disruption but also has potential to trigger life-threatening pulmonary embolism through thrombus detachment, thus posing major threat human health. Toll - like receptors (TLRs), essential components of innate immune system, have been increasingly acknowledged as crucial determinants pathogenesis DVT. TLRs possess ability recognize diverse range pathogen associated molecular patterns (PAMPs) endogenous danger (DAMPs). Upon activation, they cascade inflammatory responses that are intricately intertwined with thrombotic process. review comprehensively scrutinizes extant knowledge pertaining role It systematically synthesizes mechanisms underpinning participation DVT, spanning platelet endothelial cell dysfunction, leukocyte recruitment. Moreover, it delves profoundly into targeting therapeutic strategies for entails exploration development application TLR inhibitors or antagonists. By elucidating these aspects, objective proffer novel perspectives insights prevention treatment

Язык: Английский

Targeting toll-like receptors: unveiling potential therapeutic strategies for deep vein thrombosis DOI Creative Commons
Wei Shao, Zilong Wang, Jian Wu

и другие.

Frontiers in Immunology, Год журнала: 2025, Номер 16

Опубликована: Май 29, 2025

Deep vein thrombosis (DVT) is a complex multifactorial vascular disease characterized by abnormal blood stasis and coagulation within the deep veins, primarily occurring in lower limbs. This pathological condition not only causes local circulatory disruption but also has potential to trigger life-threatening pulmonary embolism through thrombus detachment, thus posing major threat human health. Toll - like receptors (TLRs), essential components of innate immune system, have been increasingly acknowledged as crucial determinants pathogenesis DVT. TLRs possess ability recognize diverse range pathogen associated molecular patterns (PAMPs) endogenous danger (DAMPs). Upon activation, they cascade inflammatory responses that are intricately intertwined with thrombotic process. review comprehensively scrutinizes extant knowledge pertaining role It systematically synthesizes mechanisms underpinning participation DVT, spanning platelet endothelial cell dysfunction, leukocyte recruitment. Moreover, it delves profoundly into targeting therapeutic strategies for entails exploration development application TLR inhibitors or antagonists. By elucidating these aspects, objective proffer novel perspectives insights prevention treatment

Язык: Английский

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