Indian Journal of Otolaryngology and Head & Neck Surgery, Год журнала: 2024, Номер 76(6), С. 5585 - 5595
Опубликована: Сен. 11, 2024
Язык: Английский
Current Fungal Infection Reports, Год журнала: 2022, Номер 16(4), С. 206 - 220
Опубликована: Сен. 29, 2022
Язык: Английский
Процитировано
31
Cureus, Год журнала: 2023, Номер unknown
Опубликована: Апрель 12, 2023
Diabetes mellitus (DM) is one of the most common chronic metabolic disorders worldwide, which increases risk and opportunistic infections. Following coronavirus disease 2019 (COVID-19) pandemic, a higher incidence rate, more severe forms disease, exacerbation hyperglycemia its complications have been observed in patients with DM. Moreover, stress-induced has many hospitalized nondiabetic after contracting COVID-19. Hyperglycemia worsens prognosis both diabetic patients. In this study, mechanism new-onset or hyperglycemia, effect treatments used for COVID-19 on importance appropriate method blood glucose (blood sugar (BS)) control during possible fate recovery from to some extent expressed.
Язык: Английский
Процитировано
19
Information, Год журнала: 2023, Номер 14(6), С. 310 - 310
Опубликована: Май 29, 2023
The prompt and accurate identification of the causes pneumonia is necessary to implement rapid treatment preventative approaches, reduce burden infections, develop more successful intervention strategies. There has been an increase in number new cases diseases known as acute respiratory distress syndrome (ARDS) a direct consequence spread COVID-19. Chest radiography evolved point that it now indispensable diagnostic tool for COVID-19 infection hospitals. To fully exploit technique, crucial design computer-aided (CAD) system assist doctors other medical professionals establishing diagnosis pneumonia. This article presents robust hybrid deep convolutional neural network (DCNN) rapidly identifying three categories (normal, (viral or bacterial)) using X-ray image data sourced from COVID-QU-Ex dataset. proposed approach on test set achieved rate 99.25% accuracy, 99.10% Kappa-score, 99.43% AUC, 99.24% F1-score, recall, 99.23% precision, respectively. outcomes experiments demonstrate presented DCNN mechanism utilising images effective.
Язык: Английский
Процитировано
8
Critical Care Explorations, Год журнала: 2023, Номер 5(4), С. e0886 - e0886
Опубликована: Март 27, 2023
IMPORTANCE: Although pulse (high-dose) methylprednisolone therapy can hypothetically control immune system flare-ups effectively, the clinical benefit of compared with dexamethasone in COVID-19 remains inconclusive. OBJECTIVES: To compare to as a treatment. DESIGN, SETTING, AND PARTICIPANTS: Using Japanese multicenter database, we identified adult patients admitted for and discharged between January 2020 December 2021 treated (250, 500, or 1,000 mg/d) IV (≥ 6 at admission day 0 1. Main Outcomes Measures: The primary outcome was in-hospital mortality. Secondary outcomes were 30-day mortality, new ICU admission, insulin initiation, fungal infection, readmission. Multivariable logistic regression conducted differentiate dose mg/d). Additionally, subgroup analyses by characteristics such need invasive mechanical ventilation (IMV) also conducted. RESULTS: A total 7,519, 197, 399, 1,046 received dexamethasone, 250, mg/d methylprednisolone, respectively. crude mortality 9.3% (702/7,519), 8.6% (17/197), 17.0% (68/399), 16.2% (169/1,046) different doses, adjusted odds ratio (95% CI) 1.26 (0.69–2.29), 1.48 (1.07–2.04), 1.75 (1.40–2.19) starting respectively, those dexamethasone. In analyses, 0.78 (0.25–2.47), 1.12 (0.55–2.27), 1.04 (0.68–1.57) among IMV, whereas 1.54 (0.77–3.08), 1.62 (1.13–2.34), 2.14 (1.64–2.80) without IMV. CONCLUSIONS RELEVANCE: Higher doses (500 may be associated worse when especially not on
Язык: Английский
Процитировано
5
Mycopathologia, Год журнала: 2023, Номер 188(5), С. 745 - 753
Опубликована: Июль 25, 2023
Язык: Английский
Процитировано
5
Revista Ibero-Americana de Humanidades, Ciências e Educação, Год журнала: 2024, Номер 10(6), С. 1992 - 2001
Опубликована: Июнь 11, 2024
A intersecção entre Diabetes Mellitus (DM) e doenças cardiovasculares (DCV) é um campo de estudo vital na medicina, dada a prevalência crescente ambas as condições sua associação com morbidade mortalidade significativas. O DM, caracterizado por disfunção metabólica, está intrinsecamente ligado ao desenvolvimento progressão DCVs, como doença arterial coronariana, acidente vascular cerebral insuficiência cardíaca. As manifestações clínicas podem variar complicações macrovasculares microvasculares, resultando em uma carga substancial para o paciente sistema saúde. Estratégias tratamento multifacetadas são necessárias mitigar os riscos associados incluindo controle glicêmico rigoroso, manejo da pressão lipídios, além intervenções comportamentais farmacológicas. Objetivo: Realizar revisão sistemática literatura avaliar relações cardiovasculares, analisando clínicas, estratégias eficácia, base evidências científicas dos últimos 10 anos. Metodologia: Para conduzir esta sistemática, seguimos protocolo do checklist PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) garantir transparência qualidade processo. Inicialmente, realizamos buscas nas bases dados PubMed, Scielo Web of Science, utilizando descritores "Diabetes Mellitus", "doenças cardiovasculares", "manifestações clínicas", "tratamento" "estratégias". Esses termos foram selecionados abranger aspectos-chave relação diabetes foco estudos publicados nos Os critérios inclusão estipularam que artigos deveriam abordar diretamente humanos, estar disponíveis inglês ter sido 2014 data pesquisa. Por outro lado, excluídos não estavam relacionados tema, ou antes 2014. Resultados: destacou forte DM DCV, variadas, aterosclerose, nefropatia diabética neuropatia autonômica. eficazes incluíram intensivo, uso estatinas inibidores SGLT2, no estilo vida. No entanto, desafios persistem prevenção das DM. Conclusão: reforça importância vigilância intervenção precoce interseção destacando necessidade abordagens multidisciplinares personalizadas otimizar resultados clínicos reduzir global pacientes
Процитировано
1
BMC Infectious Diseases, Год журнала: 2024, Номер 24(1)
Опубликована: Авг. 22, 2024
To evaluate the demographic, clinical, and prognostic characteristics of patients diagnosed with COVID-19-associated mucormycosis (CAM) in Iranian patients. This prospective observational study was conducted 8 tertiary referral ophthalmology centers different provinces Iran during fifth wave COVID-19 pandemic. All were subjected to complete history taking comprehensive ophthalmological examination underwent standard accepted treatment strategy based on disease stage. Two hundred seventy-four CAM (most males (150, 54.7%)) a mean age 56.8 ± 12.44 years enrolled. Patients cigarette smoking (Adjusted Odds Ratio (AOR) = 4.36), Intensive Care Unit admission (ICU) (AOR 16.26), higher stage 2.72), receiving endoscopic debridement transcutaneous retrobulbar amphotericin B 3.30) had odds mortality. History systemic corticosteroids significantly associated reduced mortality 0.16). Generalized Estimating Equations analysis showed that visual acuity deceased (LogMAR: 3.71, 95% CI: 3.04–4.38) worse than who discharged from hospital 2.42, 2.16–2.68) (P < 0.001). highlights significant risk factors for CAM, such as smoking, ICU admission, advanced stages, worser acuity. Conversely, corticosteroid use linked These findings underscore critical need early identification targeted interventions high-risk improve clinical outcomes.
Язык: Английский
Процитировано
1
Current Opinion in Infectious Diseases, Год журнала: 2023, Номер 36(6), С. 427 - 435
Опубликована: Сен. 21, 2023
Purpose of review Mucormycosis (MCR) is a common opportunistic mold infection, and Mucorales were recently designated by WHO as priority pathogens. The interest in this infection has risen significantly since the major outbreak MCR context COVID-19 pandemic, particularly India. Herein, we summarize (last 24 months) published information regarding clinical aspects MCR. Recent findings disease remains protean its presentation, difficult to diagnose, challenging treat. In 2021, cases COVID-19-associated mucormycosis (CAM) exploded India during manifested primarily sino-orbital or sino-cerebral disease. Its classic risk factors included triad COVID-19, uncontrolled diabetes mellitus use corticosteroids. Despite difficulties timely diagnosis MCR, significant progress been made with molecular techniques blood assist earlier diagnosis, which can facilitate appropriate therapy improve outcomes. addition, advances have imaging stage disease, determining what types multimodal are required depending on staging, tissue-based identification Mucorales. Summary Although outlook for improved, effective new antifungals, stratification, optimal multimodality approaches remain an unmet need.
Язык: Английский
Процитировано
3
The Egyptian Journal of Neurology Psychiatry and Neurosurgery, Год журнала: 2022, Номер 58(1)
Опубликована: Ноя. 8, 2022
Abstract Pandemic represents challenging medical emergency as it is usually associated with high rates of mortalities and morbidities. Along the last 2 half years world has faced emergence severe acute respiratory syndrome corona virus pandemic that caught agencies health authorities by surprise costed more than billion morbidities 6 million mortalities. Unfortunately, way developed countries contained novel was unsatisfactory in means early quarantines well obtaining distributing an effective vaccine. This failure management might have been responsible for a new potential caused monkeypox virus. current review article, detailed comparison presented between based on virological characteristics, role spread, pathogenesis, neuropsychiatric manifestations, treatment management. It obvious both viruses major causing various manifestations. Neurological manifestations are either bound directly to spread central peripheral nervous system or secondary triggering immune reaction. Psychiatric ones mostly related stigmatization, isolation changes takes place neurotransmitters their metabolites within system. Dealing properly through previously learned lessons from protect pandemic.
Язык: Английский
Процитировано
5
Antibiotics, Год журнала: 2022, Номер 12(1), С. 31 - 31
Опубликована: Дек. 25, 2022
Mucormycosis is a rare fungal infection, with high mortality, commonly associated diabetes, malignancies, immunosuppressive therapy, and other immunodeficiency conditions. The emergence of mucormycosis cases has been advanced by the COVID-19 pandemic. Clinical presentation variable, from asymptomatic to persistent fever or localized infections. We present case Romanian old man, without diabetes immunodepression, who developed severe rhino-orbital bacterial superinfections, Pseudomonas aeruginosa Klebsiella pneumoniae. late diagnostic antifungal treatment was related extensive lesions, bone tissue loss, required complex reconstruction procedures. review relationships between mucormycosis, COVID-19, suspicion index should be increased in medical practice. COVID-19-Associated-Mucormycosis currently challenging, calling for multidisciplinary collaboration.
Язык: Английский
Процитировано
5