Is post-COVID osteonecrosis of jaw (PCONJ) Masquerading as osteomyelitis ? A largest unicentric report of 13 cases

Advances in Oral and Maxillofacial Surgery, Год журнала: 2023, Номер 11, С. 100435 - 100435

Опубликована: Июнь 1, 2023

The purpose of this study was to ascertain the correlation between COVID-19 infection and jaw osteonecrosis, along with identification risk factors that could be associated development condition. Another aim our is establish whether maxillofacial osteonecrosis an early or late complication seen in patients. This a retrospective conducted over period two years. Case records patients history severe COVID steroid treatment who later developed were evaluated. 13 age range from 8 years 70 identified. Osteonecrosis as 21 months after COVID-19. majority cases involved maxilla, one case bi-jaw involvement, presented isolated mandibular involvement. 6 diabetic 11 gave provocative dental like extraction. A triad post-COVID coagulopathy, administration, may contribute which without pre-existing systemic illness present

Язык: Английский

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Rise of mucormycosis during the COVID-19 pandemic and the challenges faced.

PubMed, Год журнала: 2023, Номер 9(1), С. 44 - 55

Опубликована: Март 1, 2023

Mucormycosis (previously called zygomycosis) is a diverse group of increasingly recognized and frequently fatal mycotic diseases caused by members the class zygomycetes. around 80 times more common in India, compared to other developed countries, with frequency 0.14 cases per 1,000 population. The most frequent causative agent mucormycosis following genera from Order Mucorales Rhizopus, Mucor, Rhizomucor, Absidia, Apophysomyces, Cunninghamella, Saksenaea. major risk factors for development are diabetic ketoacidosis, deferoxamine treatment, cancer, solid organ or bone marrow transplantations, prolonged steroid use, extreme malnutrition, neutropenia. clinical forms rhino-orbital-cerebral, pulmonary, cutaneous, gastrointestinal. During second wave COVID-19, there was rapid increase severity than before. Amphotericin B currently found be an effective drug as it have broad-spectrum activity posaconazole used salvage therapy. Newer triazole isavuconazole also against mucormycosis. This study aimed review various studies on laboratory diagnosis treatment

Язык: Английский

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Candida Species Isolation from Hospitalized Patients with COVID-19—A Retrospective Study

Diagnostics, Год журнала: 2022, Номер 12(12), С. 3065 - 3065

Опубликована: Дек. 6, 2022

Coronavirus disease 2019 (COVID-19), a characterized by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has so far led to hundreds of millions infections and deaths. Fungal are known complicate COVID-19 patients associated with significant morbidity mortality. The aim this study was assess the incidence positive cultures for Candida spp. among hospitalized COVID-19, describe their characteristics identify factors overall mortality in patient population. Hospitalized isolation were retrospectively assessed clinical, laboratory microbiological evaluated. In total, 69 had culture spp., representing rate 4.5% all patients. Their median age 78 years (IQR 67–85 years) 44.9% male. who died older, more likely have diagnosis dementia, higher Charlson comorbidity index, score 4C score. identified multivariate logistic regression analysis model be independently most commonly species C. albicans, followed tropicalis glabrata common source urine, even though cases not true infection. Thus, may used from different body specimens risk stratification.

Язык: Английский

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Predicting intracranial involvement: Unveiling perineural spread in COVID-19-associated mucormycosis, a novel phenomenon

Medical Mycology, Год журнала: 2023, Номер 62(1)

Опубликована: Дек. 21, 2023

Abstract This study aimed to investigate the risk factors associated with intracranial involvement in COVID-19-associated mucormycosis (CAM) and develop a nomogram model for predicting of involvement, specific focus on perineural spread. An ambispective analysis was conducted 275 CAM patients who received comprehensive treatment. Univariable multivariable logistic regression analyses were performed identify independent factors, created based results analysis. The performance evaluated using receiver operating characteristic (ROC) curve, discriminatory capacity assessed area under curve (AUC). model's calibration through Hosmer Lemeshow test. In results, revealed that age (OR: 1.23, 95% CI 1.06–3.79), HbA1c 7.168, 1.724–25.788), spread 6.3, 1.281–19.874), disease stage CAM. developed demonstrated good discriminative an AUC 0.821 (95% 0.713–0.909) as indicated by ROC curve. showed well-calibrated, test yielded P-value 0.992, indicating fit model. conclusion, this found particularly exhibits spread, which is predictive factor involvement. A incorporating age, HbA1c, stage, successfully both in-patient out-patient settings.

Язык: Английский

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COVID-19-Associated Pulmonary Mucormycosis: An Underdiagnosed Entity with High Mortality

Mycopathologia, Год журнала: 2022, Номер 187(4), С. 405 - 406

Опубликована: Июнь 12, 2022

Язык: Английский

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Exenteración ocular en la mucormicosis rino-órbito-cerebral

Revista ORL, Год журнала: 2024, Номер 15(2), С. e31941 - e31941

Опубликована: Фев. 28, 2024

Introducción: La mucormicosis es una infección generada por hongos aerobios muy agresiva que pude involucrar vía aérea superior y extenderse a estructuras adyacentes. Objetivo: Analizar la asociación entre el deceso exenteración ocular en pacientes con rino-orbito-cerebral. Método: Se analizaron los aspectos clínicos desenlace de empleó estadística descriptiva, se Ji cuadrado para asociación, riesgo utilizó odd ratio, considerando como significativo un valor p≤0.05. Resultados: De 45, 11 no cumplieron criterios inclusión, encontraron asociaciones sexo, diabetes otras comorbilidades, estadios MROC deceso, COVID-19, ni hemoglobina glucosilada (HbA1c). Sin embargo, lisis ósea tomografía (p=0.001), tipo procedimiento quirúrgico (p=0.002), (p=0.001) asociaron significativamente deceso. diferencias niveles proteína C reactiva (PCR) (p=0.035), velocidad sedimentación globular (VSG) (p=0.056), recuento absoluto neutrófilos (p=0.000) muerte. Discusión: decisión ocular, aspecto complejo MROC, existen autores quienes señalan impacto psicológico proporción sustancial pacientes. Conclusiones: Las únicas características asociadas estudio fueron presencia ocular.

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Mucormycosis as a complication of COVID-19 coronavirus infection: eye symptoms

Russian Ophthalmological Journal, Год журнала: 2024, Номер 17(2), С. 116 - 120

Опубликована: Июль 1, 2024

COVID-19 causes an immunosuppressive condition and increases the risk of secondary infections, including fungal diseases such as mucormycosis (MM), so doctors should be aware possibility MM development in patients. Since no specific complaints or clinical symptoms exist disease is rare, especially developed countries with a moderate climate, it often impossible to diagnose at initial examination. Therefore, detection pathogen (mycelium zygomycetes) plays key role diagnosis. Over 70 % patients experience eye damages. According literature, most common manifestations thereof are blepharoptosis, ophthalmoplegia, exophthalmos, injection conjunctival chemosis. Quite often, have pains, orbital cellulitis phlegmon orbit, accompanied by decrease vision. For effective treatment this severe infectious complication, which takes form deep aggressive mycosis, interdisciplinary approach necessary. The complex make use antimycotic agents symptomatic therapy, and, essentially, surgical rehabilitation infection foci removing affected necrotic tissues. prognosis always very serious.

Язык: Английский

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Collaborative Study of COVID-19 Associated Rhino- Orbital-Cerebral Mucormycosis in Iran (CA-ROCM-IR): A Preliminary Report

Research Square (Research Square), Год журнала: 2023, Номер unknown

Опубликована: Янв. 31, 2023

The outbreak of COVID-19 associated rhino-orbital-cerebral mucormycosis (CA-ROCM) through the latest waves pandemic in several countries gathered attention to this rare fungal infection. This prospective observational study aims evaluate demographic and medical profile, clinical signs symptoms (with a special focus on ophthalmic findings), imaging features, outcome CA-ROCM patients. collaborative Associated Rhino-Orbital-Cerebral Mucormycosis Iran (CA-ROCM-IR) has been conducted 8 tertiary referral ophthalmology centers among different provinces during fifth wave pandemic. All patients were subjected complete history taking comprehensive ophthalmological examination, underwent standard accepted treatment strategy based disease stage. present report is preliminary results project study. Two hundred seventy-four patients, including 150 males (54.7%), who had mean age 56.8 ± 12.44 years, enrolled. Diabetes mellitus was most prevalent (82.8%) Supplemental oxygen administration corticosteroid use due large proportion (68.2%, 73.7% respectively). common primary complaints facial pain (47.4%), swelling (38.3%), nasal discharge (32.5%). Ptosis (58%), periorbital (46%), congestion (40.5%) A majority (80.3%) diagnosed at stage 3 or higher ROCM rate ocular involvement whom 92.3%. affected paranasal sinus ethmoid (75.2%), followed by maxillary (70.8%). total 30 (10.9%) expired before from hospitals. Patients with cigarette smoking (OR = 7.25), ICU admission 87.36), 4.22), receiving endoscopic debridement transcutaneous retrobulbar amphotericin B (TRAMB) 4.20), bilateral 2.94) upper odds for death hospital. History systemic corticosteroids significantly reduced mortality 0.058, P 0.006). Also, GEE analysis showed statistically significant LogMAR visual acuity score (3.71, 95% CI: 3.04–4.38) compared discharged hospitals (2.42, 2.16–2.68) (P < 0.001).

Язык: Английский

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A Case of Cerebro-pulmonary Mucormycosis Associated with COVID-19

Respiratory Case Reports, Год журнала: 2023, Номер 12(2), С. 70 - 74

Опубликована: Янв. 1, 2023

Mucormycosis is a fungal infection that common worldwide and has high mortality rate after COVID-19 disease.We present here the case of 55-yearold male who developed cerebral-pulmonary mucormycosis during voriconazole treatment.The patient presented with hemoptysis, had history uncontrolled diabetes due to high-dose longterm use corticosteroids for treatment COVID-19.He was treated medically liposomal amphotericin-B oral posaconazole, lung lesion subsequently removed surgically.

Язык: Английский

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Clinical Profile and Factors Associated with Adverse Outcomes in Coronavirus Disease 2019-associated Mucormycosis: A Single-centre Study

touchREVIEWS in Endocrinology, Год журнала: 2023, Номер 19(2), С. 2 - 2

Опубликована: Янв. 1, 2023

Background: The coronavirus disease 2019 (COVID-19) pandemic was associated with an increased incidence of mucormycosis globally. However, the clinical pattern, epidemiologic features and risk factors for adverse outcomes are not well established. Methods: We performed a retrospective analysis data from patients hospitalized proven between April 2021 August 2021. Patients were managed multi-disciplinary approach involving medical, surgical, comorbidity treatment. presentation, management details, complications outcomes, including mortality, reviewed records. Results: mean age presentation 53.7 (± 11.8) years, 88 (84.6%) men. Of 104 cases COVID-19-associated mucormycosis, 97 (93.27%) had diabetes, 80.8% haemoglobin A1C (HbA1c) ≥6.4% at diagnosis. Seventy percent diabetes experienced steroid-induced hyperglycaemia during Even appropriate treatment, 17 (16.35%) died. High HbA1c creatinine levels, presence chronic kidney (CKD), need intensive care unit admission, orbital evisceration high mortality on multivariate logistic regression analysis. Cox revealed that overall by factor 12% each 1 percentage point increase in (hazard ratio 1.12; 95% confidence interval 0.95–1.31). even higher when CKD 1.82; 0.24–14.00). Conclusion: CKD, aggressive requiring predictors mucormycosis. these should be more actively to reduce morbidity mortality.

Язык: Английский

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