Prevalence of Chronic Pulmonary Aspergillosis in Patients With Mycobacterial and Non‐Mycobacterial Tuberculosis Infection of the Lung: A Systematic Review and Meta‐Analysis DOI
Inderpaul Singh Sehgal, Soundappan Kathirvel, Ritesh Agarwal

и другие.

Mycoses, Год журнала: 2025, Номер 68(4)

Опубликована: Апрель 1, 2025

ABSTRACT Background Post‐mycobacterial residual lung abnormality (PMLA) from prior tuberculous (PTLA) or non‐tuberculous mycobacterial (PNTLA) infections predisposes to chronic pulmonary aspergillosis (CPA). However, the prevalence of CPA in patients with PMLA remains uncertain. We aimed determine PMLA. Methods performed a systematic search PubMed and Embase databases up January 31, 2025, identify studies reporting PTLA PNTLA (excluding those active tuberculosis). The pooled was calculated using frequentist meta‐analysis (primary outcome), Bayesian trim‐and‐fill methods as sensitivity analyses. Study heterogeneity ( I 2 ) publication bias were assessed. multivariable meta‐regression evaluate factors affecting heterogeneity. Results Thirty‐one (4172 13,905 PNTLA) included. Frequentist yielded 18% (95% confidence interval [CI], 11.6–25.4). analysis informative priors estimated 7.1% Credible Index, 4.5–10.4), adjustment for suggested be 3.4% CI, 0.69–7.7). On analysis, we found higher hospital‐based studies, high TB burden settings prospective cross‐sectional study designs; although (23.1%) than (7%), it not significantly different. detected substantial = 98.8%) bias. Conclusion There is PMLA, particularly TB‐endemic regions hospital settings. Patients should routinely screened

Язык: Английский

Prevalence of Chronic Pulmonary Aspergillosis in Patients With Mycobacterial and Non‐Mycobacterial Tuberculosis Infection of the Lung: A Systematic Review and Meta‐Analysis DOI
Inderpaul Singh Sehgal, Soundappan Kathirvel, Ritesh Agarwal

и другие.

Mycoses, Год журнала: 2025, Номер 68(4)

Опубликована: Апрель 1, 2025

ABSTRACT Background Post‐mycobacterial residual lung abnormality (PMLA) from prior tuberculous (PTLA) or non‐tuberculous mycobacterial (PNTLA) infections predisposes to chronic pulmonary aspergillosis (CPA). However, the prevalence of CPA in patients with PMLA remains uncertain. We aimed determine PMLA. Methods performed a systematic search PubMed and Embase databases up January 31, 2025, identify studies reporting PTLA PNTLA (excluding those active tuberculosis). The pooled was calculated using frequentist meta‐analysis (primary outcome), Bayesian trim‐and‐fill methods as sensitivity analyses. Study heterogeneity ( I 2 ) publication bias were assessed. multivariable meta‐regression evaluate factors affecting heterogeneity. Results Thirty‐one (4172 13,905 PNTLA) included. Frequentist yielded 18% (95% confidence interval [CI], 11.6–25.4). analysis informative priors estimated 7.1% Credible Index, 4.5–10.4), adjustment for suggested be 3.4% CI, 0.69–7.7). On analysis, we found higher hospital‐based studies, high TB burden settings prospective cross‐sectional study designs; although (23.1%) than (7%), it not significantly different. detected substantial = 98.8%) bias. Conclusion There is PMLA, particularly TB‐endemic regions hospital settings. Patients should routinely screened

Язык: Английский

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