Monatshefte für Chemie - Chemical Monthly,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 3, 2024
Abstract
This
work
explores
the
modification
and
characterization
of
chitosan
thin
films
as
a
model
for
functionalized
polysaccharide
interfaces.
The
solid–liquid
interface
oligo-
polysaccharides
is
crucial
various
biological
processes
such
cell
adhesion
recognition.
By
covalent
surface
via
amide
formation
with
different
small
molecules
containing
carboxylic
acids,
e.g.
specially
designed
glycoside
hydrolase
inhibitors,
interactions
biomolecules
living
cells
could
potentially
be
controlled
in
future.
As
first
step
towards
this
aim,
three
fluorescent
compounds
were
conjugated
onto
nanometric
films.
layers
analysed
by
fluorescence
spectroscopy,
X-ray
photoelectron
time-of-flight
secondary
ion
mass
spectrometry,
atomic
force
microscopy,
to
proof
attachment
target
molecules.
analysis,
uniform
chemically
stable
on
demonstrated
under
conditions.
publication
serves
proof-of-concept-study
further
biofunctionalization,
pattering,
interaction
studies
involving
interfaces,
glycosidase
proteins,
or
cells.
Graphical
abstract
Pharmaceutics,
Год журнала:
2023,
Номер
15(3), С. 976 - 976
Опубликована: Март 17, 2023
Concurrent
developments
in
anticancer
nanotechnological
treatments
have
been
observed
as
the
burden
of
cancer
increases
every
year.
The
21st
century
has
seen
a
transformation
study
medicine
thanks
to
advancement
field
material
science
and
nanomedicine.
Improved
drug
delivery
systems
with
proven
efficacy
fewer
side
effects
made
possible.
Nanoformulations
varied
functions
are
being
created
using
lipids,
polymers,
inorganic
peptide-based
nanomedicines.
Therefore,
thorough
knowledge
these
intelligent
nanomedicines
is
crucial
for
developing
very
promising
systems.
Polymeric
micelles
often
simple
make
high
solubilization
characteristics;
result,
they
seem
be
alternative
other
nanosystems.
Even
though
recent
studies
provided
an
overview
polymeric
micelles,
here
we
included
discussion
on
“intelligent”
from
We
also
summarized
state-of-the-art
most
micellar
respect
treatments.
Additionally,
gave
significant
attention
clinical
translation
potential
treatment
various
cancers.
Journal of Controlled Release,
Год журнала:
2025,
Номер
unknown, С. 113624 - 113624
Опубликована: Март 1, 2025
Gene
therapy
has
attracted
widespread
attention
in
recent
years,
and
one
of
the
important
delivery
systems
is
LNP.
However,
many
LNPs
have
potential
toxicity
accumulate
liver.
Here,
we
designed
synthesized
a
Gemini-type
mannosylated
peptidyl
lipid
called
CManDA(M),
which,
combination
with
cytidinyl
DNCA(D)
CLD(C)
(D/50C/50
M),
could
transfect
siRNA
(siG12S)
into
A549
cells
to
target
silence
KRASG12S
gene.
The
fluorescence
intensity
tumor
area
D/50C/50
M/Cy5.5-siG12S
group
increased
by
approximately
2.5
times.
Furthermore,
full
2'-F/2'-OMe-modified
siG12Ss
also
be
transfected
M
cells,
resulting
gene
silencing.
weight
M/M3
(1.5
mg/kg,
i.v.)
was
reduced
50
%
after
administration
mouse
axillary
(A549)
model,
whereas
bioluminescence
only
30
that
blank
orthotopic
lung
cancer
model
showed
no
significant
toxicity.
Further
studies
revealed
mannose
groups
CManDA
can
exposed
on
nanoparticle
surface
bind
lectins,
shield
formation
protein
corona
alter
composition
corona,
which
aids
enhancement
its
active
targeting
function.
expected
safe
effective
helper
for
tumor-targeted
vivo.
Biomacromolecules,
Год журнала:
2024,
Номер
25(7), С. 4492 - 4509
Опубликована: Июнь 24, 2024
A
major
shortcoming
associated
with
the
application
of
enzymes
in
drug
synergism
originates
from
lack
site-specific,
multifunctional
nanomedicine.
This
study
introduces
catalytic
nanocompartments
(CNCs)
made
a
mixture
PDMS-
PeerJ,
Год журнала:
2025,
Номер
13, С. e19332 - e19332
Опубликована: Апрель 24, 2025
Tumors
pose
a
serious
threat
to
global
public
health
and
are
usually
treated
from
two
aspects:
tumor
cells
microenvironment.
Compared
with
traditional
chemotherapy
drugs,
Chinese
medicine
(TCM)
monomers
have
advantages
in
treatment,
such
as
multiple
targets,
levels
synergistic
intervention.
However,
most
TCM
active
ingredients
disadvantages
poor
water
solubility
stability,
which
restrict
their
clinical
application.
Nano
drug
delivery
systems
the
functions
of
improving
bioavailability
anti-tumor
ingredients,
enhancing
tissue
targeting,
achieving
controlled
release,
inhibiting
multidrug
resistance.
free
monomers,
they
higher
therapeutic
effects
fewer
side
effects.
This
article
summarizes
five
commonly
used
monomer
nanocarriers,
including
lipid
nanomaterials,
exosomes,
polymer
micelles,
carbon
nanotubes,
dendrimers,
explains
mechanisms
after
combining
TCM,
cell
proliferation
metastasis,
regulating
microenvironment,
etc
.
At
same
time,
potential
nano
combined
radiotherapy
immunotherapy
is
discussed,
well
current
problems
toxicity,
long-term
complex
amplification
process,
future
development
directions,
aiming
provide
reference
for
promoting
application
ingredients.
Frontiers in Immunology,
Год журнала:
2025,
Номер
16
Опубликована: Май 13, 2025
Vaccine
adjuvants,
as
key
components
in
enhancing
vaccine
immunogenicity,
play
a
vital
role
modern
vaccinology.
This
review
systematically
examines
the
historical
evolution
and
mechanisms
of
with
particular
emphasis
on
innovative
advancements
aluminum-based
emulsion-based
nucleic
acid
adjuvants
(e.g.,
CpG
oligonucleotides).
Specifically,
aluminum
enhance
immune
responses
through
particle
formation/antigen
adsorption,
inflammatory
cascade
activation,
T-cell
stimulation.
Emulsion
amplify
immunogenicity
via
antigen
depot
effects
localized
inflammation,
while
like
oligonucleotides
directly
activate
B
cells
dendritic
to
promote
Th1-type
memory
generation.
The
article
further
explores
prospective
applications
these
novel
combating
emerging
pathogens
(including
influenza
SARS-CoV-2),
particularly
highlighting
their
significance
improving
potency
durability.
Moreover,
this
underscores
critical
importance
adjuvant
development
next-generation
design
provides
theoretical
foundations
for
creating
safer,
effective
adjuvant.
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Май 30, 2025
Abstract
Oral
administration
has
long
been
considered
the
most
convenient
method
of
drug
delivery,
requiring
minimal
expertise
and
invasiveness.
Unlike
injections,
it
avoids
discomfort,
wound
infections,
complications,
leading
to
higher
patient
compliance.
However,
effectiveness
oral
delivery
is
often
hindered
by
harsh
biological
barriers
gastrointestinal
tract,
which
limit
bioaccessibility
bioavailability
drugs.
The
development
systems
(ODDSs)
represents
a
critical
area
for
advancement
pharmacotherapy.
This
review
highlights
characteristics
precise
targeting
mechanisms
ODDSs.
It
first
examines
unique
properties
each
compartment,
including
stomach,
small
intestine,
intestinal
mucus,
epithelial
barrier,
colon.
Based
on
these
features,
outlines
strategies
design
principles
ODDSs
aimed
at
overcoming
enhance
disease
treatment.
Lastly,
discusses
challenges
potential
future
directions
ODDS
development,
emphasizing
their
importance
advancing
technologies
accelerating
growth.
Graphical
