The GABAA receptor RDL modulates the auditory sensitivity of malaria mosquitoes.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июнь 6, 2024

Malaria mosquitoes mate in crowded, and noisy, swarms. A vital stage of their precopulatory behaviour involves detecting the faint flight tone a mating partner amidst noise from hundreds other mosquitoes. This exquisite sensory performance is enabled by complex auditory system with remarkable features. One such feature vast efferent control system, which provides mosquito ear required plasticity to adapt various external internal changes. In this paper, we study role GABA, one main signalling molecules ear, its interactions octopamine, another neurotransmitter network. We show that GABA released malaria nerve receptors are expressed including GABAA receptor Resistance Dieldrin (RDL), target for evolution insecticide resistance. Using picrotoxin antagonize RDL receptors, discovered multiple effects at mechanical electrical level. At level, blocking promotes erection antennal fibrillae cessation flagellar self-sustained oscillations. These not observed knockouts octopamine AgOctbeta2, suggesting mediated through release ear. Electrically, injection increases spontaneous firing neurons direct current (DC) responses stimulation both wildtype AgOctbeta2 mutants, indicating may also modulate sensitivity via octopamine-independent pathways. summary, our experiments uncover distinct roles as well synergistic octopamine. The data fundamental controlling function implicate natural populations.

Язык: Английский

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Auditory System of Blood-Sucking Mosquitoes (Diptera, Culicidae)

Сенсорные системы, Год журнала: 2024, Номер 38(3), С. 3 - 30

Опубликована: Сен. 8, 2024

Язык: Английский

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The Auditory System of Blood-Sucking Mosquitoes (Diptera, Culicidae)

Neuroscience and Behavioral Physiology, Год журнала: 2024, Номер 54(9), С. 1447 - 1465

Опубликована: Ноя. 1, 2024

Язык: Английский

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