Identifying new therapeutics for focused ultrasound-enhanced drug delivery in the management of glioblastoma DOI Creative Commons
Ryan Holman, Nathan McDannold

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Март 13, 2025

Glioblastoma, a grade IV astrocytoma, typically has poor prognosis, with most patients succumbing within eighteen months of diagnosis and few experiencing long-term survival. Focused ultrasound, an emerging localized therapy, shown promising results in early-phase studies for glioblastoma by improving the uptake temozolomide carboplatin. The blood-brain barrier is critical to homeostasis regulating movement substances between bloodstream central nervous system. While this helps prevent infections from bloodborne pathogens, it also hinders delivery cancer therapies gliomas. Combining focused ultrasound circulating microbubbles enhances local permeability, facilitating intratumoral systemic therapies. purpose study was identify new therapeutics treatment drug via ultrasound. This review provides overview current standard care newly diagnosed recurrent glioblastoma, identifies indicated treatment, discusses key aspects microbubble resonators, describes devices under evaluation human trials, concludes perspective future studies.

Язык: Английский

Nanotherapy of Glioblastoma—Where Hope Grows DOI Open Access
Jan Grzegorzewski, Maciej Michalak,

Maria Wołoszczuk

и другие.

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(5), С. 1814 - 1814

Опубликована: Фев. 20, 2025

Localization in the central nervous system, diffuse growth, presence of stem cells, and numerous resistance mechanisms, all make glioblastoma (GBM) an incurable tumor. The standard treatment GBM consisting surgery; radio- chemotherapy with temozolomide provides insufficient therapeutic benefit needs to be updated effective modern solutions. One most promising intensively explored approaches against is use nanotherapy. first, so far only, nanoparticle-based therapy approved for NanoThermTM. It based on iron oxide nanoparticles thermal ablation tumor a magnetic field. Numerous other types nanotherapies are being evaluated, including polymer lipid-based nanoformulations, nanodiscs, dendrimers, metallic, silica, or bioderived nanoparticles, among others. advantages these nanoscale drug carriers include improved penetration across blood-brain barrier, targeted delivery, biocompatibility, lower systemic toxicity, while major problems their implementation involve scaling up production high costs. Nevertheless, taking impressive benefits into consideration, it seems obvious that combined effort scientific world will need taken tackle challenges implement novel therapies clinics, giving hope battle can finally won.

Язык: Английский

Процитировано

0
Ultrasound-responsive nanoparticles for imaging and therapy of brain tumors DOI Creative Commons
Zhiguang Chen, Liang Sang,

Zhai Qixi

и другие.

Materials Today Bio, Год журнала: 2025, Номер unknown, С. 101661 - 101661

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Delivering Gd-Labeled IgG Antibodies Into the Mouse Brain Following Focused Ultrasound Treatment DOI Creative Commons
Hasan Körük,

Chris Payne,

Paul Cressey

и другие.

Ultrasound in Medicine & Biology, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Antibody-based therapy has emerged as a powerful tool for targeted treatment of neurological diseases, such brain cancer and neurodegenerative disorders. However, direct, scalable, safe confirmation antibody delivery into the remains challenging. Antibodies can be effectively tracked when tagged with molecules that are detectable by medical imaging modalities, MRI, PET, or SPECT. In this study, we aimed to confirm gadolinium (Gd)-labeled IgG mouse using following exposure focused ultrasound (FUS) circulating microbubbles. We acquired MR images evaluate region. First, quantified signal Gd-labeled antibodies in phantoms preclinical 9.4 T clinical 3 MRI scanners. Then, determined optimal parameters non-invasively safely disrupt blood-brain barrier localized reversible manner monitor murine brain, respectively. confirmed reliably delivered FUS microbubble track their biodistribution within parenchyma clinically relevant image sequences. The maximum detected volume Gd-IgG (n = 4) was 0.12 ± 0.02 mm3 at t 75.3 17.3 minutes treatment. This work paves way scalable non-ionizing method performing evaluating brain.

Язык: Английский

Процитировано

0
Identifying new therapeutics for focused ultrasound-enhanced drug delivery in the management of glioblastoma DOI Creative Commons
Ryan Holman, Nathan McDannold

Frontiers in Oncology, Год журнала: 2025, Номер 15

Опубликована: Март 13, 2025

Glioblastoma, a grade IV astrocytoma, typically has poor prognosis, with most patients succumbing within eighteen months of diagnosis and few experiencing long-term survival. Focused ultrasound, an emerging localized therapy, shown promising results in early-phase studies for glioblastoma by improving the uptake temozolomide carboplatin. The blood-brain barrier is critical to homeostasis regulating movement substances between bloodstream central nervous system. While this helps prevent infections from bloodborne pathogens, it also hinders delivery cancer therapies gliomas. Combining focused ultrasound circulating microbubbles enhances local permeability, facilitating intratumoral systemic therapies. purpose study was identify new therapeutics treatment drug via ultrasound. This review provides overview current standard care newly diagnosed recurrent glioblastoma, identifies indicated treatment, discusses key aspects microbubble resonators, describes devices under evaluation human trials, concludes perspective future studies.

Язык: Английский

Процитировано

0