Fluids and Barriers of the CNS,
Год журнала:
2024,
Номер
21(1)
Опубликована: Ноя. 21, 2024
The
Blood-Brain
Barrier
(BBB)
is
a
complex
and
dynamic
interface
that
regulates
the
exchange
of
molecules
cells
between
blood
central
nervous
system.
It
undergoes
structural
functional
throughout
oxidative
stress
inflammation,
which
may
compromise
its
integrity
contribute
to
pathogenesis
neurodegenerative
diseases.
Maintaining
BBB
utmost
importance
in
preventing
wide
range
neurological
disorders.
NRF2
main
transcription
factor
cellular
redox
balance
inflammation-related
gene
expression.
has
also
demonstrated
potential
role
regulating
tight
junction
contributing
inhibition
ECM
remodeling,
by
reducing
expression
several
metalloprotease
family
members
involved
maintaining
function.
Overall,
we
review
current
insights
on
addressing
protection
against
effects
dysfunction,
discuss
involvement
maintenance
different
neuropathological
diseases,
as
well
as,
some
activators
have
been
used
vitro
vivo
animal
models
for
barrier
dysfunction.
Thus,
emerging
evidence
suggests
upregulation
target
genes
could
suppress
stress,
neuroinflammation,
restore
integrity,
increase
protection.
Journal of Cerebral Blood Flow & Metabolism,
Год журнала:
2023,
Номер
44(3), С. 367 - 383
Опубликована: Ноя. 16, 2023
The
crosstalk
between
reactive
astrocytes
and
infiltrated
immune
cells
plays
a
critical
role
in
maintaining
blood-brain
barrier
(BBB)
integrity.
However,
how
interact
with
the
effect
of
their
interaction
on
BBB
integrity
after
hemorrhagic
stroke
are
still
unclear.
By
performing
RNA
sequencing
that
were
activated
by
interleukin-1α
(IL-1α),
tumor
necrosis
factor
α
(TNFα),
complement
component
1q
(C1q)
treatment,
we
found
CCL5
was
among
top
upregulated
genes.
Immunostaining
western
blot
results
demonstrated
increased
mice
brain
stroke.
Flow
cytometry
showed
knockout
astrocytic
reduced
infiltration
CD8+
but
not
CD4+
T
myeloid
into
(p
<
0.05).
In
addition,
tight
junction-related
proteins
ZO-1
Occludin
expression;
Evans
blue
leakage,
perforin
granzyme
B
improved
neurobehavioral
outcomes
0.05),
while
transplantation
reversed
these
protective
effects.
Moreover,
co-culture
bEnd.3
induced
apoptosis
cells,
which
rescued
inhibiting
perforin.
conclusion,
our
study
suggests
mediated
represents
an
important
therapeutic
target
for
protecting
Neural Regeneration Research,
Год журнала:
2023,
Номер
19(1), С. 35 - 42
Опубликована: Май 25, 2023
Traumatic
spinal
cord
injury
is
a
devastating
disorder
characterized
by
sensory,
motor,
and
autonomic
dysfunction
that
severely
compromises
an
individual's
ability
to
perform
activities
of
daily
living.
These
adverse
outcomes
are
closely
related
the
complex
mechanism
injury,
limited
regenerative
capacity
central
neurons,
inhibitory
environment
formed
traumatic
injury.
Disruption
microcirculation
important
pathophysiological
A
number
therapeutic
agents
have
been
shown
improve
environment,
mitigate
secondary
damage,
and/or
promote
regeneration
repair.
Among
them,
has
become
target
for
treatment
Drug
interventions
targeting
can
microenvironment
recovery
following
drugs
structure
function
essential
maintaining
normal
axons,
glial
cells.
This
review
discusses
role
in
including
its
histopathological
changes.
Further,
it
summarizes
progress
drug
therapies
after
International Journal of Molecular Sciences,
Год журнала:
2023,
Номер
24(16), С. 12899 - 12899
Опубликована: Авг. 17, 2023
In
recent
times,
there
has
been
a
significant
increase
in
researchers’
interest
the
functions
of
microRNAs
and
role
these
molecules
pathogenesis
many
multifactorial
diseases.
This
is
related
to
diagnostic
prognostic
potential
microRNA
expression
levels
as
well
prospects
using
it
personalized
targeted
therapy.
review
literature
analyzes
existing
scientific
data
on
involvement
molecular
cellular
mechanisms
underlying
development
pathologies
such
Alzheimer’s
disease,
cerebral
ischemia
reperfusion
injury,
dysfunction
blood–brain
barrier.
Fluids and Barriers of the CNS,
Год журнала:
2024,
Номер
21(1)
Опубликована: Ноя. 21, 2024
The
Blood-Brain
Barrier
(BBB)
is
a
complex
and
dynamic
interface
that
regulates
the
exchange
of
molecules
cells
between
blood
central
nervous
system.
It
undergoes
structural
functional
throughout
oxidative
stress
inflammation,
which
may
compromise
its
integrity
contribute
to
pathogenesis
neurodegenerative
diseases.
Maintaining
BBB
utmost
importance
in
preventing
wide
range
neurological
disorders.
NRF2
main
transcription
factor
cellular
redox
balance
inflammation-related
gene
expression.
has
also
demonstrated
potential
role
regulating
tight
junction
contributing
inhibition
ECM
remodeling,
by
reducing
expression
several
metalloprotease
family
members
involved
maintaining
function.
Overall,
we
review
current
insights
on
addressing
protection
against
effects
dysfunction,
discuss
involvement
maintenance
different
neuropathological
diseases,
as
well
as,
some
activators
have
been
used
vitro
vivo
animal
models
for
barrier
dysfunction.
Thus,
emerging
evidence
suggests
upregulation
target
genes
could
suppress
stress,
neuroinflammation,
restore
integrity,
increase
protection.
