Brain Research, Год журнала: 2024, Номер 1831, С. 148826 - 148826
Опубликована: Фев. 23, 2024
Язык: Английский
Life Sciences, Год журнала: 2024, Номер 347, С. 122651 - 122651
Опубликована: Апрель 19, 2024
Язык: Английский
Процитировано
16
Signal Transduction and Targeted Therapy, Год журнала: 2025, Номер 10(1)
Опубликована: Фев. 18, 2025
Язык: Английский
Процитировано
5
Neurochemistry International, Год журнала: 2024, Номер 178, С. 105798 - 105798
Опубликована: Июнь 29, 2024
Язык: Английский
Процитировано
9
Journal of Neural Transmission, Год журнала: 2024, Номер 131(12), С. 1367 - 1387
Опубликована: Авг. 7, 2024
Millions of individuals around the world are afflicted with Parkinson's disease (PD), a prevalent and incapacitating neurodegenerative disorder. Dr. Reichmann, distinguished professor neurologist, has made substantial advancements in domain PD research, encompassing both fundamental scientific investigations practical applications. His research illuminated etiology treatment PD, as well function energy metabolism premotor symptoms. As precursor to number neurotransmitters neuromodulators that implicated pathophysiology he also investigated application tryptophan (Trp) derivatives disease. principal findings insights summarized synthesized this narrative review article, which emphasizes challenges implications for future research. This aims identify analyze key contributions Reichmann field ultimate goal informing directions domain. By examining Reichmann's work, study seeks provide comprehensive understanding his major how they can be applied advance diagnosis PD. paper explores potential intersection emerging avenues, such investigation Trp its metabolites, particularly kynurenines, could lead new therapeutic strategies managing disorders like
Язык: Английский
Процитировано
9
Biology, Год журнала: 2024, Номер 13(9), С. 719 - 719
Опубликована: Сен. 12, 2024
Neurodegenerative diseases (NDs), like amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), and Parkinson's (PD), primarily affect the central nervous system, leading to progressive neuronal loss motor cognitive dysfunction. However, recent studies have revealed that muscle tissue also plays a significant role in these diseases. ALS is characterized by severe wasting as result of neuron degeneration, well alterations gene expression, protein aggregation, oxidative stress. Muscle atrophy mitochondrial dysfunction are observed AD, which may exacerbate decline due systemic metabolic dysregulation. PD patients exhibit fiber atrophy, altered composition, α-synuclein aggregation within cells, contributing symptoms progression. Systemic inflammation impaired degradation pathways common among disorders, highlighting key player Understanding muscle-related changes offers potential therapeutic avenues, such targeting function, reducing inflammation, promoting regeneration with exercise pharmacological interventions. This review emphasizes importance considering an integrative approach neurodegenerative research, both peripheral pathological mechanisms, order develop more effective treatments improve patient outcomes.
Язык: Английский
Процитировано
8
Phytotherapy Research, Год журнала: 2024, Номер 38(4), С. 1838 - 1862
Опубликована: Фев. 14, 2024
Abstract Mitochondrial damage is associated with the development of Parkinson's disease (PD), indicating that mitochondrial‐targeted treatments could hold promise as disease‐modifying approaches for PD. Notably, natural compounds have demonstrated ability to modulate mitochondrial‐related processes. In this review article, we discussed possible neuroprotective mechanisms against PD in modulating mitophagy and mitochondrial function. A comprehensive literature search on related treatment by regulating function was conducted from PubMed, Web Science Chinese National Knowledge Infrastructure databases their inception until April 2023. We summarize recent advancements mitophagy's molecular mechanisms, including upstream downstream processes, its relationship PD‐related genes or proteins. Importantly, highlight how can therapeutically regulate various processes through multiple targets pathways alleviate oxidative stress, neuroinflammation, Lewy's body aggregation apoptosis, which are key contributors pathogenesis. Unlike single‐target strategy modern medicine, provide neuroprotection ameliorating targeting PINK1/parkin pathway, NIX/BNIP3 autophagosome formation (i.e., LC3 p62). Given prevalence neurodegenerative diseases, exploring exact mechanism dysfunction shed light highly effective adjuvant therapies other disorders.
Язык: Английский
Процитировано
7
Biomolecules, Год журнала: 2024, Номер 14(1), С. 73 - 73
Опубликована: Янв. 5, 2024
Parkinson’s disease (PD) is the second most prevalent neurodegenerative movement disorder worldwide, which primarily characterized by motor impairments. Even though multiple hypotheses have been proposed over decades that explain pathogenesis of PD, presently, there are no cures or promising preventive therapies for PD. This could be attributed to intricate pathophysiology PD and poorly understood molecular mechanism. To address these challenges comprehensively, a thorough model imperative nuanced understanding PD’s underlying pathogenic mechanisms. review offers detailed analysis current state knowledge regarding mechanisms with particular emphasis on roles played gene-based factors in disease’s development progression. study includes an extensive discussion proteins mutations primary genes linked including α-synuclein, GBA1, LRRK2, VPS35, PINK1, DJ-1, Parkin. Further, this explores plausible DAergic neural loss, non-motor non-dopaminergic pathologies, risk associated The present will encourage related research fields understand better analyze status biochemical might contribute design efficacious safe treatment strategies future endeavors.
Язык: Английский
Процитировано
6
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Май 1, 2024
Introduction: The synthetic pyrethroid derivative fenpropathrin (FNE), a commonly used insecticide, has been associated with various toxic effects in mammals, particularly neurotoxicity. study addressed the hallmarks of pathophysiology Parkinson’s disease upon oral exposure to mainly alteration dopaminergic markers, oxidative stress, and molecular docking rat models. In addition, protective effect curcumin-encapsulated chitosan nanoparticles (CRM-Chs-NPs) was also assessed. Methods: 60-day trial, 40 male Sprague Dawley rats were divided into 4 groups: Control, CRM-Chs-NPs (curcumin-encapsulated nanoparticles), FNE (15 mg/kg bw), + CRM-Chs-NPs. Results: induced reactive oxygen species generation, ATP production disruption, activation inflammatory apoptotic pathways, mitochondrial function dynamics impairment, neurotransmitter level perturbation, mitophagy promotion brains. Molecular analysis revealed that interacts key binding sites dopamine synthesis transport proteins. On other hand, mitigated FNE’s by enhancing dynamics, antioxidant activity, promoting anti-inflammatory antiapoptotic responses. Conclusion: summary, appears induce degeneration through mechanisms, emerged as potential therapeutic intervention for protecting nervous tissue microenvironment.
Язык: Английский
Процитировано
5
Neurological Research, Год журнала: 2025, Номер unknown, С. 1 - 10
Опубликована: Март 18, 2025
The primary aim was to investigate the relationship between serum growth differentiation factor-15 (GDF15) levels and non-motor symptom (NMS) in Parkinson's disease (PD) patients. secondary explore diagnostic value of GDF15 for specific NMS. A total 102 PD patients were enrolled this study, including 47 males 55 females. Doctors collected clinical demographic information detected level GDF15. Next, linear univariate multivariate regression analyses used assess correlation Receiver operating characteristic curve analysis performed determine optimal cut-off evaluate its value. In patients, there no significant difference females (p = 0.831). Age onset, pesticide use, depression, sexual dysfunction, Epworth Sleepiness Scale (ESS) Hamilton Depression (HAMD) associated with Serum negatively correlated HAMD, depression dysfunction positively ESS. Each 10 pg/ml increase a 4% lower risk 5% dysfunction. Notably, may be biomarker distinguishing Elevated reduced
Язык: Английский
Процитировано
0
MedComm, Год журнала: 2023, Номер 4(6)
Опубликована: Дек. 1, 2023
Mitochondria are multifaceted and dynamic organelles regulating various important cellular processes from signal transduction to determining cell fate. As properties of mitochondria, fusion fission accompanied with mitophagy, undergo constant changes in number morphology sustain mitochondrial homeostasis response context changes. Thus, the dysregulation dynamics mitophagy is unsurprisingly related diseases, but unclear underlying mechanism hinders their clinical application. In this review, we summarize recent developments molecular particularly different roles key components context. We also target treatment diseases cardiovascular system, nervous respiratory tumor metabolism demanding high-energy. these it common that excessive dominant by impaired mitophagy. But there have been many conflicting findings about them recently, which specifically highlighted view. look forward will help broaden our understanding be beneficial discovery novel selective therapeutic targets.
Язык: Английский
Процитировано
11