Critical role of microRNAs in cellular quality control during brain aging and neurological disorders: Interplay between autophagy and proteostasis

Life Sciences, Год журнала: 2025, Номер 369, С. 123563 - 123563

Опубликована: Март 13, 2025

A decline in cellular quality control mechanisms is one of the processes brain aging. Autophagy and proteostasis are two regulatory that maintain component turnover to preserve homeostasis, optimal function, neuronal health by eliminating damaged aggregated proteins preventing neurodegenerative disorders (NDDs). Impaired autophagy significant hallmarks aging many age-related NDDs. MicroRNAs noncoding RNA molecules have recently been shown be essential for regulating several biological processes, such as autophagy, proteostasis, differentiation, development targeting mRNA's 3'untranslated region (3'UTR). During aging, miRNAs dysregulate resulting abnormal activity protein aggregation, a characteristic This review highlights complex interactions orchestration autophagy. dysregulation impairs autophagic flux accelerates disorders, neuroinflammation, neurodegeneration. Understanding among miRNAs, novel therapeutics

Язык: Английский

Gnetupendin A protects against ischemic stroke through activating the PI3K/AKT/mTOR-dependent autophagy pathway

Phytomedicine, Год журнала: 2024, Номер 135, С. 156233 - 156233

Опубликована: Ноя. 8, 2024

Язык: Английский