Synergy, Additive Effects, and Antagonism of Drugs with Plant Bioactive Compounds

Drugs and Drug Candidates, Год журнала: 2025, Номер 4(1), С. 4 - 4

Опубликована: Фев. 5, 2025

Background/Objectives: The interaction of bioactive compounds derived from plants with drugs has become a significant area investigation due to its potential improve, reduce, or have no effect on therapeutic outcomes. Due the dual these interactions, elucidating underlying mechanisms is essential for establishing strategy. This study emphasizes findings, mechanisms, and clinical implications drug–plant interactions. It calls more studies seek safe effective incorporation into practice. Methods: To identify relevant studies, we performed systematic literature search based various scientific databases 11 August 2024 30 December 2024. will be keywords such as synergy, antagonism, plant compounds, drug interactions supplemented secondary terms phytochemicals, herb-drug pharmacokinetics, pharmacodynamics. Results: Plant bioactives, including polyphenols, flavonoids, alkaloids, terpenoids, display valuable biological activities that can interact medications in three principal ways: additive effects, antagonism. Synergy occurs when combined effects chemicals pharmaceuticals outweigh sum their separate increasing effectiveness allowing dosage decrease reduce adverse effects. Additive occur impact equals total individual resulting better outcomes without risk. Antagonism ingredient reduces counteracts medicine, thereby jeopardizing treatment. In addition, specific may discernible effect. chemical makeup chemicals, medication patient characteristics genetics metabolism all intricacy Conclusions: Pharmacokinetics pharmacodynamics considerably modulated through components, which cause efficacy increase toxicity agents. More are needed clarify action, prove relevance, create guidelines co-administration. integrative approach mitigate those risks allow optimization by introducing pharmacogenomics personalized medicine approaches.

Язык: Английский

The potential of medicinal plants in tuberculosis treatment: Indigenous plants used by the Anak Dalam tribe of Jambi, Indonesia

South African Journal of Botany, Год журнала: 2025, Номер 180, С. 688 - 709

Опубликована: Апрель 3, 2025

Язык: Английский

Gallic acid enhances memory, learning and reduces neuroinflammation in a rat model of scopolamine-induced cholinergic dysfunction

Inflammopharmacology, Год журнала: 2025, Номер unknown

Опубликована: Март 16, 2025

Язык: Английский