Long-term cognitive and autonomic effects of COVID-19 in young adults: a cross-sectional study at 28 months
Annals of Medicine,
Год журнала:
2025,
Номер
57(1)
Опубликована: Янв. 16, 2025
The
COVID-19
pandemic,
caused
by
SARS-CoV-2,
has
had
profound
global
impacts
since
its
emergence
in
late
2019.
Whilst
acute
symptoms
are
well-documented,
increasing
evidence
suggests
long-term
consequences
extending
beyond
the
phase.
This
study
aimed
to
investigate
cognitive
and
autonomic
effects
of
young
adults.
We
conducted
a
cross-sectional
comparing
adults
with
history
(n
=
34)
matched
controls
34).
Cognitive
function
was
assessed
using
Sternberg
Task,
Stroop
Go/No-Go
Task
(GNG).
Autonomic
evaluated
heart
rate
variability
(HRV)
parameters.
average
time
interval
between
infection
testing
28.2
months.
group
showed
significantly
increased
reaction
2-item
absent
condition
(p
0.044)
errors
4-item
present
0.012)
neutral
response
0.028)
normalized
for
completing
task
0.022)
Task.
No
significant
differences
were
found
GNG
HRV
parameters
did
not
differ
groups,
although
trends
toward
higher
overall
observed
group.
Young
who
approximately
28
months
ago
show
minimal
impact
on
regulation.
However,
subtle
inefficiencies
persist,
particularly
working
memory
executive
tasks.
These
findings
suggest
generally
favorable
prognosis
following
mild
moderate
but
highlight
need
further
investigation
into
persistent
effects.
Язык: Английский
Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis
BMC Medicine,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 6, 2025
Since
its
emergence
in
2019,
COVID-19
has
continued
to
pose
significant
threats
both
the
physical
and
mental
health
of
global
population,
as
well
healthcare
systems
worldwide
(Raman
et
al.,
Eur
Heart
J
43:1157–1172,
2022).
Emerging
evidence
indicates
that
may
lead
post-acute
syndrome
(PACS)
with
cardiovascular
implications,
potentially
driven
by
factors
such
ACE2
interaction
viruses,
systemic
inflammation,
endothelial
dysfunction.
However,
there
remains
a
limited
amount
research
on
manifestations
PACS,
which
delay
development
optimal
treatment
strategies
for
affected
patients.
Therefore,
it
is
crucial
investigate
prevalence
sequelae
patients
determine
whether
infection
acts
an
independent
risk
factor
these
outcomes.
This
meta-analysis
adhered
PRISMA
guidelines
was
registered
PROSPERO
(CRD42024524290).
A
systematic
search
PubMed,
Embase,
Cochrane
Library
conducted
up
March
17,
2024.
The
primary
outcomes
included
hypertension,
palpitations,
chest
pain,
pooled
effect
estimate
reported
proportions
odds
ratios
(ORs)
95%
confidence
intervals
(CIs).
Sensitivity
subgroup
analysis
were
performed
assess
robustness
results
identify
sources
heterogeneity.
total
37
studies,
encompassing
2,965,467
patients,
analysis.
Pooled
from
case–control
studies
revealed
that,
compared
control
group,
ORs
pain
group
4.0
(95%
CI:
1.6,
10.0).
palpitation
hypertension
3.4
1.1,
10.2)
1.7
1.8),
respectively.
PACS
experiencing
palpitation,
22%
14%,
33%),
18%
13%,
24%),
19%
12%,
31%),
Our
findings
indicate
15%
experience
sequelae.
Furthermore,
significantly
increases
likelihood
developing
uninfected
individuals.
Future
should
prioritize
investigating
underlying
pathological
mechanisms
targeted
preventive
management
strategies.
CRD42024524290.
Язык: Английский
Estimated prevalence of post-intensive care cognitive impairment at short-term and long-term follow-ups: a proportional meta-analysis of observational studies
Annals of Intensive Care,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 10, 2025
Abstract
Objective
Evidence
of
the
overall
estimated
prevalence
post-intensive
care
cognitive
impairment
among
critically
ill
survivors
discharged
from
intensive
units
at
short-term
and
long-term
follow-ups
is
lacking.
This
study
aimed
to
estimate
time
<
1
month,
3
month(s),
4
6
months,
7–12
>
12
months
units.
Methods
Electronic
databases
including
PubMed,
Cochrane
Library,
EMBASE,
CINAHL
Plus,
Web
Science,
PsycINFO
via
ProQuest
were
searched
inception
through
July
2024.
Studies
that
reported
on
patients
with
valid
measures
included.
Data
extraction
risk
bias
assessment
performed
independently
for
all
included
studies
according
Preferred
Reporting
Items
Systematic
Reviews
Meta-analyses
reporting
guidelines.
Newcastle–Ottawa
Scale
was
used
measure
bias.
pooled
using
a
random-effects
model.
The
primary
outcome
proportions
impairment.
Results
In
total,
58
involving
347,940
rates
follow-up
timepoints
1–3
4–6
49.8%
[95%
Prediction
Interval
(PI),
39.9%–59.7%,
n
=
19],
45.1%
(95%
PI,
34.8%–55.5%,
23),
47.9%
35.9%–60.0%,
16),
28.3%
19.9%–37.6%,
19),
30.4%
18.4%–43.9%,
7),
respectively.
Subgroup
analysis
showed
significant
differences
between
continents
designs
observed.
Conclusions
differed
different
timepoints.
highest
within
first
three
follow-up,
less
than
one
six
months.
No
in
only
coronavirus
disease
2019
survivors.
These
fundings
highlight
need
further
research
develop
targeted
interventions
prevent
or
manage
follow-ups.
Язык: Английский
Six-month follow-up of multidomain cognitive impairment in non-hospitalized individuals with post-COVID-19 syndrome
European Archives of Psychiatry and Clinical Neuroscience,
Год журнала:
2024,
Номер
274(8), С. 1945 - 1957
Опубликована: Июль 24, 2024
Abstract
Some
people
infected
with
SARS-CoV-2
report
persisting
symptoms
following
acute
infection.
If
these
persist
for
over
three
months,
they
are
classified
as
post-COVID-19
syndrome
(PCS).
Although
PCS
is
frequently
reported,
detailed
longitudinal
neuropsychological
characterization
remains
scarce.
We
aimed
to
describe
the
trajectory
of
cognitive
and
neuropsychiatric
symptoms.
42
individuals
deficits
after
asymptomatic
mild/moderate
COVID-19
at
study
inclusion
received
assessment
baseline
(BL)
follow-up
(FU;
six
months
BL).
Assessments
included
comprehensive
testing
five
neurocognitive
domains,
two
screening
tests,
questionnaires
on
depression,
anxiety,
sleep,
fatigue,
health-related
quality
life.
Results
showed
high
rates
subjective
complaints
BL
FU
(95.2%
versus
88.1%)
without
significant
change
time.
However,
objectively
measured
disorder
(NCD)
decreased
(61.9%
42.9%).
All
domains
were
affected,
yet
most
found
in
learning
memory,
followed
by
executive
functions,
complex
attention,
language,
perceptual
motor
functions.
In
NCD,
first
mentioned
improved
significantly
time,
while
last
remained
unchanged.
Cognitive
tests
did
not
prove
valuable
detecting
impairment.
Neuropsychiatric
constant
except
life,
which
improved.
This
emphasizes
importance
research
provides
insights
into
long-term
impairments
PCS.
While
performance
many
Язык: Английский
Comprehensive neuropsychological assessment and predictors of cognitive functioning at six months after COVID-19 in patients treated in the ICU, regular hospital ward, or isolated at home
Applied Neuropsychology Adult,
Год журнала:
2025,
Номер
unknown, С. 1 - 13
Опубликована: Янв. 25, 2025
Cognitive
impairment
in
patients
with
COVID-19
has
been
reported,
but
findings
are
inconsistent.
This
study
assessed
cognitive
functioning
6
months
post-infection
across
three
severity
groups
compared
to
non-COVID
controls.
Seventy-two
ICU-treated,
49
ward-treated,
and
44
home-isolated
COVID-19,
along
48
controls,
underwent
neuropsychological
evaluation
assessment
of
subjective
symptoms,
depressive
fatigue.
test
scores
were
using
ANCOVA.
Associations
between
variables
including
demographics,
illness
severity,
comorbidities,
fatigue,
ICU-related
factors
examined
hierarchical
linear
regression
models.
Results
showed
no
significant
differences
performance
frequencies
However,
reported
higher
levels
fatigue
Predictors
included
age,
education,
and,
a
lesser
extent,
comorbidities.
depression,
or
did
not
significantly
impact
performance.
These
suggest
that
while
individual
impairments
may
exist,
overall
was
comparable
Язык: Английский
Coronavirus anxiety and its relationship to mood and cognition in post-acute sequelae of COVID-19
Applied Neuropsychology Adult,
Год журнала:
2025,
Номер
unknown, С. 1 - 9
Опубликована: Фев. 24, 2025
Background:
Subjective
and
objective
cognitive
dysfunction
may
be
observed
in
patients
with
post-acute
sequelae
of
COVID-19
(PASC),
are
associated
depression
general
anxiety.
Coronavirus
anxiety
(CA)
is
subjective
cognition,
depression,
community
samples.
We
determined
the
base
rate
CA
PASC
its
relation
to
mood,
cognition.
Design
Methods:
Participants
were
79
referred
for
clinical
neuropsychological
evaluation,
who
completed
Anxiety
Scale
(CAS),
BDI-II,
BAI,
BRIEF-A,
tests.
Results:
Base
clinically
elevated
CAS
was
low
(5.1%),
whereas
BDI-II
(78.6%),
BAI
(80%),
BRIEF-A
Global
Executive
Composite
(GEC;
60.3%)
high.
Objective
most
common
Color-Word
Interference
(20.8%)
Trail
Making
Test
(TMT)
Part-B
(23.1%).
Greater
worse
anxiety,
GEC,
TMT
Part-A.
Higher
GAI
accounted
GEC
association.
Longer
time
since
pandemic
onset
only
decreasing
CA.
Exploratory
factor
analysis
supported
a
unidimensional
structure
CAS.
Conclusions:
Clinically
rare
seen
evaluation.
mood
executive
dysfunction,
though
latter
by
Patients
endorse
high
level
would
likely
benefit
from
interventions
reduce
emotional
distress.
Язык: Английский
Melatonin regulation of phase separation in Neuro-PASC: out-maneuvering Janus-faced amyloids
Exploration of neuroscience,
Год журнала:
2025,
Номер
4
Опубликована: Март 24, 2025
The
SAR-CoV-2
virus
has
evolved
to
co-exist
with
human
hosts,
albeit
at
a
substantial
energetic
cost
resulting
in
post-infection
neurological
manifestations
[Neuro-post-acute
sequelae
of
SARS-CoV-2
infection
(PASC)]
that
significantly
impact
public
health
and
economic
productivity
on
global
scale.
One
the
main
molecular
mechanisms
responsible
for
development
Neuro-PASC,
individuals
all
ages,
is
formation
inadequate
proteolysis/clearance
phase-separated
amyloid
crystalline
aggregates—a
hallmark
feature
aging-related
neurodegenerative
disorders.
Amyloidogenesis
during
viral
persistence
natural,
inevitable,
protective
defense
response
exacerbated
by
SARS-CoV-2.
Acting
as
chemical
catalyst,
accelerates
hydrophobic
collapse
heterogeneous
nucleation
amorphous
amyloids
into
stable
β-sheet
aggregates.
clearance
aggregates
most
effective
slow
wave
sleep,
when
high
levels
adenosine
triphosphate
(ATP)—a
biphasic
modulator
biomolecular
condensates—and
melatonin
are
available
solubilize
removal.
dysregulation
mitochondrial
dynamics
SARS-CoV-2,
particular
fusion
fission
homeostasis,
impairs
proper
distinct
subpopulations
can
remedy
challenges
created
diversion
substrates
away
from
oxidative
phosphorylation
towards
glycolysis
support
replication
maintenance.
subsequent
reduction
ATP
inhibition
synthesis
sleep
results
incomplete
brain
aggregates,
leading
commonly
associated
age-related
Exogenous
not
only
prevents
dysfunction
but
also
elevates
production,
effectively
augmenting
solubilizing
effect
moiety
ensure
timely,
optimal
disaggregation
pathogenic
prevention
attenuation
Neuro-PASC.
Язык: Английский
Associations of cognitive test performance with self-reported mental health, cognition, and quality of life in adults with functional seizures: A systematic review and meta-analysis
The Clinical Neuropsychologist,
Год журнала:
2024,
Номер
unknown, С. 1 - 26
Опубликована: Дек. 15, 2024
Objective:
People
with
functional
seizures
(FS)
have
frequent
and
disabling
cognitive
dysfunction
mental
health
symptoms,
low
quality
of
life.
However,
interrelationships
among
these
constructs
are
poorly
understood.
In
this
meta-analysis,
we
examined
associations
between
objective
(i.e.
performance-based)
testing
self-reported
(i)
health,
(ii)
cognition,
(iii)
life
in
FS.
Method:
We
searched
MEDLINE,
Embase,
PsycINFO,
Web
Science,
the
final
search
on
June
10,
2024.
Inclusion
criteria
were
studies
documenting
relationships
test
scores
subjective)
and/or
adults
Exclusion
mixed
FS/epilepsy
samples.
A
modified
Newcastle-Ottawa
Scale
evaluated
risk
bias.
This
project
is
registered
as
CRD42023392385
PROSPERO.
Results:
Initially,
4,054
unique
reports
identified,
sample
including
24
articles
1,173
people
Mean
age
was
35.9
(SD
=
3.9),
mean
education
12.6
1.3),
proportion
women
73.9%.
Risk
bias
moderate,
due
part
to
inconsistent
reporting
confounding
demographic
variables.
Significant
found
global
cognition
(k
21,
Z
-0.23
[0.04],
95%
CI
-0.30,
-0.16),
depression
11,
-0.13
[0.05],
-0.21,
-0.04),
5,
-0.16
-0.26,
-0.06),
-0.17
-0.24,
-0.10).
Exploratory
analyses
showed
select
constructs.
Conclusions:
Objective
reliably
associated
Scientific
clinical
implications
discussed.
Язык: Английский