IntechOpen eBooks,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 20, 2025
Ionic
liquids
(ILs)
have
emerged
as
a
cutting-edge
frontier
in
the
realm
of
science
and
technology,
offering
unique
blend
tunable
physicochemical
biological
features
with
eco-friendly
characteristics.
Thus,
ILs
exhibit
broad
spectrum
applications
pharmacology,
pharmaceuticals,
medicine,
pharmaceutical
fields,
providing
solutions
to
challenges
drug
formulation
delivery.
The
focus
this
chapter
is
on
application
IL
methodologies
strategies
resolve
critical
issues
within
field,
such
polymorphism,
low
solubility,
stability,
bioavailability,
which
are
problems
solid-state
pharmaceuticals.
innovative
use
carriers
for
active
ingredients
(APIs)
presents
highly
promising
avenue
addressing
these
challenges.
In
conclusion,
detailed
utilization
applications,
strategic
design
liquid
salts
has
potential
revolutionize
way
we
address
development,
manufacturing,
developing
biocompatible
ILs.
Acta Pharmaceutica Sinica B,
Год журнала:
2024,
Номер
14(11), С. 4683 - 4716
Опубликована: Сен. 2, 2024
About
40%
of
approved
drugs
and
nearly
90%
drug
candidates
are
poorly
water-soluble
drugs.
Low
solubility
reduces
the
drugability.
Effectively
improving
bioavailability
is
a
critical
issue
that
needs
to
be
urgently
addressed
in
development
application.
This
review
briefly
introduces
conventional
solubilization
techniques
such
as
solubilizers,
hydrotropes,
cosolvents,
prodrugs,
salt
modification,
micronization,
cyclodextrin
inclusion,
solid
dispersions,
details
crystallization
strategies,
ionic
liquids,
polymer-based,
lipid-based,
inorganic-based
carriers
bioavailability.
Some
most
commonly
used
carrier
materials
for
presented.
Several
using
summarized.
Furthermore,
this
summarizes
mechanism
each
technique,
reviews
latest
research
advances
challenges,
evaluates
potential
clinical
translation.
could
guide
selection
approach,
dosage
form,
administration
route
Moreover,
we
discuss
several
promising
attracting
increasing
attention
worldwide.
International Journal of Environmental Health Research,
Год журнала:
2024,
Номер
unknown, С. 1 - 22
Опубликована: Июль 5, 2024
The
present
investigation
examines
the
antimicrobial
and
antifungal
characteristics
of
natural
deep
eutectic
solvents
(NADES)
apple
vinegar
in
relation
to
a
diverse
array
bacterial
fungal
strains.
clinical
strains,
including
gram-negative
gram-positive,
pathogen
Candida
albicans,
were
subjected
solid
medium
diffusion
determine
inhibitory
effects
these
compounds.
results
show
that
NADES
has
superior
action
compared
vinegar.
observed
zones
for
varied
length
from
16.5
24.2
16
52.5
mm,
respectively.
obtained
indicate
no
synergy
is
this
mixture
(50%
AV
+
50%
NADES).
range
values
bactericidal
concentrations
(MBC)
minimal
(MIC)
was
0.0125
0.2
0.4
µl/ml,
Antibacterial
chemicals
may
be
found
NADES,
with
offering
environmentally
safe
substitutes
traditional
antibiotics.
Additional
suggested
refine
compounds
wide
bacteria,
which
could
create
solutions
are
both
highly
effective
specifically
targeted,
thereby
extensive
potential
medicine
environment.
