Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
11
Опубликована: Сен. 16, 2024
Red
blood
cells
(RBCs)
naturally
trap
some
bacterial
pathogens
in
the
circulation
and
kill
them
by
oxidative
stress.
Following
neutralization,
bacteria
are
presented
to
antigen-presenting
spleen
RBCs.
This
ability
of
RBCs
has
been
harnessed
develop
a
system
where
they
play
crucial
role
enhancing
immune
response,
offering
novel
approach
enhance
body’s
immunity.
In
this
work,
conjugate,
G-OVA,
was
formed
connecting
β-glucan
OVA
through
disulfide
bond.
Poly
(lactic-co-glycolic
acid)
(PLGA)
then
employed
encapsulate
yielding
G-OVA-PLGA.
Finally,
nanoparticles
were
adsorbed
onto
G-OVA-PLGA@RBC.
The
results
demonstrated
that
delivery
enhanced
antibody
response
antigens
both
vitro
vivo
.
objective
study
investigate
increased
activity
G-OVA-PLGA
facilitated
transportation
elucidate
its
underlying
mechanisms.
These
findings
anticipated
contribute
valuable
insights
for
development
efficient
safe
enhancers.
Regenerative Biomaterials,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 20, 2024
Abstract
Low
tumor
enrichment
remains
a
serious
and
urgent
problem
for
drug
delivery
in
cancer
therapy.
Accurate
targeting
of
sites
is
still
critical
aim
Though
there
have
been
variety
strategies
to
improve
the
enrichment,
biological
barriers
cause
most
delivered
guests
fail
or
be
excreted
before
they
work.
Recently,
cell
membrane-based
systems
attracted
huge
amount
attention
due
their
advantages
such
as
easy
access,
good
biocompatibility
immune
escape,
which
contribute
biomimetic
structures
specific
surface
proteins.
Furthermore,
are
referred
homologous-targeting
function
exhibit
significantly
high
adhesion
internalization
homologous-type
cells
even
though
exact
mechanism
not
entirely
revealed.
Here,
we
summarize
sources
characterizations
membrane
systems,
including
reconstructed
single
hybrid
nano-/microcarriers,
well
engineered
cells.
Additionally,
advanced
applications
these
therapy
categorized
summarized
according
components
membranes.
The
potential
factors
related
homologous
also
discussed.
By
discussing
applications,
challenges
opportunities,
expect
far-reaching
development
preclinic
clinics.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 11, 2023
Abstract
Less
than
5%
of
intravenously-injected
nanoparticles
(NPs)
reach
destined
sites
in
the
body
due
to
opsonization
and
immune-based
clearance
vascular
circulation.
By
hitchhiking
situ
onto
specific
blood
components
post-injection,
NPs
can
selectively
target
tissue
for
unprecedentedly
high
drug
delivery
rates
.
Choline
carboxylate
ionic
liquids
(ILs)
are
biocompatible
liquid
salts
<100℃
composed
bulky
asymmetric
cations
anions.
This
class
ILs
has
been
previously
shown
significantly
extend
circulation
time
redirect
biodistribution
BALB/c
mice
post-IV
injection
via
on
red
cell
(RBC)
membranes.
Herein,
we
synthesized
&
screened
60
choline
carboxylic
acid-based
coat
PLGA
present
impact
structurally
engineering
coordinated
anion
identity
interface
hitchhike
lymphocytes,
monocytes,
granulocytes,
platelets,
RBCs
whole
mouse
targeted
delivery.
Furthermore,
find
this
nanoparticle
platform
be
(non-cytotoxic),
translate
human
by
resisting
serum
uptake
maintaining
modest
hitchhiking,
also
retention
over
24
hours
healthy
adult
after
IV
injection.
Because
their
altered
profiles,
additionally
observe
dramatically
different
organ
accumulation
profiles
compared
bare
NPs.
study
establishes
an
initial
breakthrough
a
modular
transformative
targeting
technology
with
efficacy
safety
bloodstream
administration.
Frontiers in Veterinary Science,
Год журнала:
2024,
Номер
11
Опубликована: Сен. 16, 2024
Red
blood
cells
(RBCs)
naturally
trap
some
bacterial
pathogens
in
the
circulation
and
kill
them
by
oxidative
stress.
Following
neutralization,
bacteria
are
presented
to
antigen-presenting
spleen
RBCs.
This
ability
of
RBCs
has
been
harnessed
develop
a
system
where
they
play
crucial
role
enhancing
immune
response,
offering
novel
approach
enhance
body’s
immunity.
In
this
work,
conjugate,
G-OVA,
was
formed
connecting
β-glucan
OVA
through
disulfide
bond.
Poly
(lactic-co-glycolic
acid)
(PLGA)
then
employed
encapsulate
yielding
G-OVA-PLGA.
Finally,
nanoparticles
were
adsorbed
onto
G-OVA-PLGA@RBC.
The
results
demonstrated
that
delivery
enhanced
antibody
response
antigens
both
vitro
vivo
.
objective
study
investigate
increased
activity
G-OVA-PLGA
facilitated
transportation
elucidate
its
underlying
mechanisms.
These
findings
anticipated
contribute
valuable
insights
for
development
efficient
safe
enhancers.
