Discussion on the optimization of personalized medication using information systems based on pharmacogenomics: an example using colorectal cancer
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
15
Опубликована: Янв. 14, 2025
Pharmacogenomics
(PGx)
is
a
powerful
tool
for
clinical
optimization
of
drug
efficacy
and
safety.
However,
due
to
many
factors
affecting
drugs
in
the
real
world,
PGx
still
accounts
small
proportion
actual
application
scenarios.
Therefore,
based
on
information
software,
pharmacists
use
their
professional
advantages
integrate
into
all
aspects
pharmaceutical
care,
which
conducive
promoting
development
personalized
medicine.
In
this
paper,
establishment
an
software
platform
summarized
medication
program
PGx.
Taking
colorectal
cancers
(CRC)
as
example,
paper
also
discusses
role
different
working
modes
participation
management
CRC
patients
by
with
help
systems.
Finally,
we
recommendations
guidelines
provide
reference
follow-up
care.
Язык: Английский
Impact and Enablers of Pharmacogenetic-Informed Treatment Decisions—A Longitudinal Mixed-Methods Study Exploring the Patient Perspective
Pharmacy,
Год журнала:
2025,
Номер
13(1), С. 14 - 14
Опубликована: Янв. 31, 2025
Pharmacogenetic
(PGx)
testing
is
a
promising
approach
for
optimizing
drug
therapies.
However,
there
limited
knowledge
regarding
its
real-world
utilization
and
long-term
impact
in
clinical
practice.
This
study
assessed
how
often
PGx
information
informs
treatment
decisions
evaluated
patients’
perspectives
on
use
non-use,
identifying
enablers
implementation.
A
mixed-methods
was
conducted
with
24
patients
median
of
1
year
after
testing.
Medication
health-related
data
were
collected
at
enrollment
the
follow-up
later
using
semi-structured
questionnaire.
At
follow-up,
62
medication
changes
identified
18
patients.
four
per
patient
initiated
mainly
by
medical
specialists
(58%).
considered
15
39
(63%).
Patient-reported
factors
contributing
to
non-use
included
lack
interest
among
healthcare
professionals
(HCPs),
structural
administrative
barriers,
an
over-reliance
advocacy.
Potential
should
address
targeted
education,
interprofessional
collaboration,
awareness
policymakers,
concise
recommendations
focused
PGx-actionable
drugs
from
providers.
By
implementing
these
interdependent
enablers,
can
evolve
into
long-term,
clinically
integrated
cornerstone
individualized
pharmacotherapy.
Язык: Английский
The Critical Role of Pharmacists in the Clinical Delivery of Pharmacogenetics in the U.S
Pharmacy,
Год журнала:
2023,
Номер
11(5), С. 144 - 144
Опубликована: Сен. 10, 2023
Since
the
rebirth
of
pharmacogenomics
(PGx)
in
1990s
and
2000s,
with
new
discoveries
genetic
variation
underlying
adverse
drug
response
analytical
technologies
such
as
sequencing
microarrays,
there
has
been
much
interest
clinical
application
PGx
testing.
The
early
involvement
pharmacists
studies
establishment
organizations
to
support
dissemination
information
about
variants
have
naturally
resulted
leaders
implementation.
This
paper
presents
an
overview
evolving
role
pharmacists,
discusses
potential
challenges
future
paths,
primarily
focused
U.S.
Pharmacists
positioned
themselves
testing,
will
prepare
next
generation
utilize
testing
their
scope
practice.
Язык: Английский
A Guide to a Pharmacist-Led Pharmacogenetic Testing and Counselling Service in an Interprofessional Healthcare Setting
Pharmacy,
Год журнала:
2022,
Номер
10(4), С. 86 - 86
Опубликована: Июль 19, 2022
Genetic
predisposition
is
one
factor
influencing
interindividual
drug
response.
Pharmacogenetic
information
can
be
used
to
guide
the
selection
and
dosing
of
certain
drugs.
However,
implementation
pharmacogenetics
(PGx)
in
clinical
practice
remains
challenging.
Defining
a
formal
structure,
as
well
concrete
procedures
clearly
defined
responsibilities,
may
facilitate
increase
use
PGx
practice.
Over
140
patient
cases
from
an
observational
study
Switzerland
formed
basis
for
design
refinement
pharmacist-led
testing
counselling
service
(PGx
service)
interprofessional
setting.
Herein,
we
six-step
approach,
including:
(1)
referral;
(2)
pre-test-counselling;
(3)
testing;
(4)
medication
review;
(5)
counselling;
(6)
follow-up.
The
approach
supports
importance
collaboration
role
pharmacists
across
healthcare
settings.
Язык: Английский
Overcoming Barriers: Strategies for Implementing Pharmacist-Led Pharmacogenetic Services in Swiss Clinical Practice
Genes,
Год журнала:
2024,
Номер
15(7), С. 862 - 862
Опубликована: Июль 1, 2024
There
is
growing
evidence
that
pharmacogenetic
analysis
can
improve
drug
therapy
for
individual
patients.
In
Switzerland,
pharmacists
are
legally
authorized
to
initiate
tests.
However,
tests
rarely
conducted
in
Swiss
pharmacies.
Therefore,
we
aimed
identify
implementation
strategies
facilitate
the
integration
of
a
pharmacist-led
service
into
clinical
practice.
To
achieve
this,
semi-structured
interviews
with
and
physicians
regarding
process
service.
We
utilized
Consolidated
Framework
Implementation
Research
(CFIR)
potential
facilitators
barriers
process.
Additionally,
employed
Expert
Recommendations
Implementing
Change
(ERIC)
mentioned
used
CFIR-ERIC
matching
tool
additional
strategies.
obtained
interview
responses
from
nine
physicians.
From
these
responses,
identified
7
CFIR
constructs
as
12
barriers.
Some
most
commonly
included
unclear
procedures,
lack
cost
coverage
by
health
care
insurance,
insufficient
pharmacogenetics
knowledge,
interprofessional
collaboration,
communication
patient,
inadequate
e-health
technologies.
23
interviewees
using
ERIC
45
tool.
summary,
found
significant
hinder
this
new
hope
highlighting
strategies,
advance
Switzerland.
Язык: Английский
Comparative analysis of pharmacists’ knowledge and perception on the utilization of precision medicine to reduce antimicrobial resistance in Lebanon and Greece
Deleted Journal,
Год журнала:
2024,
Номер
21(1)
Опубликована: Дек. 8, 2024
Abstract
Pharmacogenomics
and
precision
medicine
are
promising
new
tools
in
the
fight
against
antimicrobial
resistance
by
providing
personalized
treatment
approaches
based
on
an
individual
genetic
makeup.
Pharmacists,
equipped
with
appropriate
education
tools,
can
play
a
significant
role
integrating
pharmacogenomics
into
clinical
practice
lead
rational
use
of
daily
patient
care.
Improving
outcomes
primary
healthcare
settings
is
ultimate
output.
To
date,
there
has
been
lack
assessment
comparison
knowledge
perceptions
pharmacists
across
different
countries.
A
self-administered
questionnaire
was
sent
to
223
participants
from
Greece
Lebanon.
Results
showed
that
96%
68%
both
countries
were
familiar
terminology
medicine.
deeper
investigation
gaps
concerning
profound
understanding
one
health
perspective
preventive
measures.
Knowledge
pharmacogenomics,
its
tests,
value
low
groups,
more
pronounced
deficiencies
Lebanese
group.
Additionally,
didn’t
perceive
their
current
implementing
combat
resistance,
but
they
expressed
openness
future
involvement
this
area.
This
research
serve
as
foundational
tool
establish
or
adjust
policies
allocate
resources
support
systems
people
enhance
implementation
low-to-middle-income
Furthermore,
it
highlights
importance
leveraging
experiences
high-income
effectively
address
challenge
resistance.
Язык: Английский