Plants,
Год журнала:
2024,
Номер
13(11), С. 1463 - 1463
Опубликована: Май 25, 2024
Chlorogenic
acid
is
one
of
the
most
prominent
bioactive
phenolic
acids
with
great
pharmacological,
cosmetic
and
nutritional
value.
The
potential
Berula
erecta
in
tissue
culture
was
investigated
for
production
chlorogenic
its
elicitation
combined
light
different
wavelengths
low
temperature.
content
samples
determined
by
HPLC-UV,
while
total
compounds
antioxidant
activity
their
ethanol
extracts
were
evaluated
spectrophotometrically.
highest
fresh
dry
biomasses
obtained
plants
grown
at
23
°C.
This
first
study
which
has
been
identified
quantified
erecta.
4.049
mg/g
DW.
It
a
28
days
after
beginning
experiment
12
°C
under
blue
light.
latter
also
contained
compounds,
showed
activity.
could,
potentially,
be
suitable
vitro
acid,
although
many
other
studies
should
conducted
before
implementation
on
an
industrial
scale.
The Plant Journal,
Год журнала:
2021,
Номер
107(5), С. 1299 - 1319
Опубликована: Июнь 25, 2021
Caffeoylquinic
acids
(CQAs)
are
specialized
plant
metabolites
we
encounter
in
our
daily
life.
Humans
consume
CQAs
mg-to-gram
quantities
through
dietary
consumption
of
products.
considered
beneficial
for
human
health,
mainly
due
to
their
anti-inflammatory
and
antioxidant
properties.
Recently,
new
biosynthetic
pathways
via
a
peroxidase-type
p-coumaric
acid
3-hydroxylase
enzyme
were
discovered.
More
recently,
GDSL
lipase-like
able
transform
monoCQAs
into
diCQA
was
identified
Ipomoea
batatas.
recently
linked
memory
improvement;
they
seem
be
strong
indirect
antioxidants
Nrf2
activation.
However,
there
is
prevalent
confusion
the
designation
nomenclature
different
CQA
isomers.
Such
inconsistencies
critical
complicate
bioactivity
assessment
since
isomers
differ
potency.
A
detailed
explanation
regarding
origin
such
provided,
recommendation
unify
suggested.
Furthermore,
studies
on
bioactivity,
plant-based
laboratory
animal
diets
contain
CQAs,
which
makes
it
difficult
include
proper
control
groups
comparison.
Therefore,
synthetic
diet
free
advised
avoid
interferences
some
may
produce
even
at
nanomolar
levels.
Biotransformation
by
gut
microbiota,
discovery
enzymatic
metabolic
pathways,
assessment,
biological
properties
with
potential
drug
development
areas
active,
ongoing
research.
This
review
focused
chemistry,
biosynthesis,
occurrence,
analytical
challenges,
reported
mono-,
di-,
tri-,
tetraCQAs.
Molecules,
Год журнала:
2023,
Номер
28(3), С. 1186 - 1186
Опубликована: Янв. 25, 2023
Nature
is
a
valuable
source
of
anti-oxidants
that
have
health-promoting
effect
by
inhibiting
various
undesirable
changes
leading
to
cell
degradation
and,
consequently,
potential
disease
ailments.
One
them
gallic
acid
which
has
been
used
as
healing
agent
since
ancient
times.
Currently,
due
beneficial
properties,
this
compound
considered
be
one
the
main
phenolic
acids
great
importance
in
numerous
industries.
It
commonly
substance
protecting
against
harmful
effects
UV
radiation,
an
astringent
cosmetic
preparations,
and
preservative
food
products.
Therefore,
now
deemed
essential
for
both
human
health
industry.
Increasingly
better
methods
its
isolation
analysis
are
being
developed,
new
solutions
sought
increase
production.
This
review,
presenting
concise
characterization
acid,
updates
knowledge
about
biological
activities
determination,
including
chromatographic
non-chromatographic
methods.
Frontiers in Nutrition,
Год журнала:
2023,
Номер
10
Опубликована: Июнь 12, 2023
Hyperuricemia
is
another
common
metabolic
disease,
which
considered
to
be
closely
related
the
development
of
many
chronic
diseases,
in
addition
"three
highs."
Currently,
although
drugs
show
positive
therapeutic
effects,
they
have
been
shown
produce
side
effects
that
can
damage
body.
There
growing
evidence
medicinal
and
edible
plants
their
bioactive
components
a
significant
effect
on
hyperuricemia.
In
this
paper,
we
review
with
uric
acid-lowering
summarize
mechanisms
different
components.
Specifically,
are
divided
into
five
categories:
flavonoids,
phenolic
acids,
alkaloids,
polysaccharides,
saponins.
These
active
substances
exhibit
by
inhibiting
acid
production,
promoting
excretion,
improving
inflammation.
Overall,
examines
potential
role
as
means
combating
hyperuricemia,
hope
providing
some
reference
value
for
treatment
Food & Function,
Год журнала:
2024,
Номер
15(13), С. 6847 - 6882
Опубликована: Янв. 1, 2024
Edible
plant
leaves
(EPLs)
constitute
a
major
renewable
functional
biomass
available
all
year
round,
providing
an
essential
source
of
polyphenols
in
the
global
diet.
Metabolites,
Год журнала:
2020,
Номер
10(5), С. 178 - 178
Опубликована: Апрель 29, 2020
Bidens
pilosa
is
an
edible
herb
from
the
Asteraceae
family
which
traditionally
consumed
as
a
leafy
vegetable.
B.
has
many
bioactivities
owing
to
its
diverse
phytochemicals,
include
aliphatics,
terpenoids,
tannins,
alkaloids,
hydroxycinnamic
acid
(HCA)
derivatives
and
other
phenylpropanoids.
The
later
compounds
such
chlorogenic
acids
(CGAs),
are
produced
either
regio-
or
geometrical
isomers.
To
profile
CGA
composition
of
pilosa,
methanol
extracts
tissues,
callus
cell
suspensions
were
utilized
for
liquid
chromatography
coupled
mass
spectrometric
detection
(UHPLC-QTOF-MS/MS).
An
optimized
in-source
collision-induced
dissociation
(ISCID)
method
capable
discriminating
between
closely
related
HCA
quinic
acids,
based
on
MS-based
fragmentation
patterns,
was
applied.
Careful
control
collision
energies
resulted
in
fragment
patterns
similar
MS2
MS3
fragmentation,
obtainable
by
typical
ion
trap
MSn
approach.
For
first
time,
ISCID
approach
shown
efficiently
discriminate
positional
isomers
containing
two
different
cinnamoyl
moieties,
mixed
di-ester
feruloyl-caffeoylquinic
(m/z
529)
coumaroyl-caffeoylquinic
499).
results
indicate
that
tissues
cultures
contained
combined
total
30
mono-,
di-,
tri-substituted
with
dominating
thereof.
In
addition,
tartaric
esters,
caftaric-
chicoric
also
identified.
Profiling
revealed
these
differentially
distributed
across
types
culture
lines
derived
leaf
stem
explants.
Molecules,
Год журнала:
2022,
Номер
27(8), С. 2462 - 2462
Опубликована: Апрель 11, 2022
Quince
(Cydonia
oblonga
Mill.)
is
a
potential
source
of
polyphenolic
compounds
related
with
beneficial
biological
processes.
In
this
study
polyphenols
from
quince
fruit
were
extracted
aqueous
acetone
at
different
ratios.
A
polyphenol
profile
was
identified
and
quantified
by
LC-ESI-QqQ.
The
antioxidant
capacity
(ORAC
DPPH)
anti-inflammatory
effect
(inhibition
COX-2
cyclooxygenase)
evaluated
in
vitro.
results
indicated
an
the
ratio
on
extraction
compounds.
higher
yields
attained
60–75%
acetone.
However,
extracts
obtained
85%
promoted
effects.
Optimal
scaling
analysis
that
hydroxycinnamic
acids
(quinic
chlorogenic),
hydroxybenzoic
(vanillic
syringic),
flavonoids
(quercetin
kaempferol),
dihydrochalcones
(neohesperidin)
flavones
(acacetin)
are
to
activity
quince.
While
phenolic
acids,
flavonols
(kaempferol-3-O-glucoside
rutin)
flavanols
(epicatechin)
generated
inhibiting
52.3%
enzyme.
Therefore,
selective
mix
can
reduce
oxidative
stress
or
inflammatory
This
suggests
use
as
natural
significant
nutraceutical
potential.
Molecules,
Год журнала:
2023,
Номер
28(8), С. 3610 - 3610
Опубликована: Апрель 21, 2023
Blueberry
is
the
source
of
a
variety
bioactive
substances,
including
phenolic
compounds,
such
as
anthocyanins,
pterostilbene,
acids,
etc.
Several
studies
have
revealed
that
polyphenols
in
blueberry
important
bioactivities
maintaining
health,
antioxidant
and
anti-tumor
activities,
immune
regulation,
prevention
chronic
diseases,
Therefore,
these
compounds
blueberries
been
widely
used
field
healthcare,
extraction,
isolation,
purification
are
prerequisites
for
their
utilization.
It
imperative
to
systematically
review
research
progress
prospects
present
blueberries.
Herein,
latest
purification,
analysis
from
reviewed,
which
can
turn
provide
foundation
further
usage
Antioxidants,
Год журнала:
2024,
Номер
13(7), С. 777 - 777
Опубликована: Июнь 27, 2024
The
interactions
between
proteins
and
chlorogenic
acid
(CGA)
have
gained
significant
attention
in
recent
years,
not
only
as
a
promising
approach
to
modify
the
structural
techno-functional
properties
of
but
also
enhance
their
bioactive
potential
food
systems.
These
can
be
divided
into
covalent
(chemical
or
irreversible)
non-covalent
(physical
reversible)
linkages.
Mechanistically,
CGA
forms
bonds
with
nucleophilic
amino
residues
by
alkaline,
free
radical,
enzymatic
approaches,
leading
changes
protein
structure
functionality,
such
solubility,
emulsification
properties,
antioxidant
activity.
In
addition,
protein–CGA
complexes
obtained
hydrogen
bonds,
hydrophobic
electrostatic
interactions,
van
der
Waals
forces,
each
offering
unique
advantages
outcomes.
This
review
highlights
mechanism
these
importance
modifying
structural,
functional,
nutritional,
physiological
attributes
animal-
plant-based
proteins.
Moreover,
applications
conjugates/complexes
are
explored
various
systems,
beverages,
films
coatings,
emulsion-based
delivery
so
on.
Overall,
this
literature
provides
an
in-depth
overview
valuable
insights
for
future
research
develop
novel
protein-based
non-food
products
improved
nutritional
functional
characteristics.
Chemistry & Biodiversity,
Год журнала:
2020,
Номер
17(4)
Опубликована: Март 18, 2020
Abstract
Chlorogenic
(5‐CQA),
1,5‐,
3,5‐,
4,5‐
and
3,4‐dicaffeoylquinic
(DCQA)
acids
were
identified
quantified
in
the
methanol
extracts
of
Inula
oculus‐christi
L.,
I.
bifrons
aschersoniana
Janka
var.
,
ensifolia
conyza
(
Griess
.)
DC.
germanica
L.
by
HPLC
analysis.
The
amount
5‐CQA
varied
from
5.48
to
28.44
mg/g
DE
highest
content
was
detected
.
1,5‐DCQA
(4.05–55.25
DE)
most
abundant
dicaffeoyl
ester
quinic
acid
followed
3,5‐DCQA,
4,5‐DCQA
3,4‐DCQA.
extract
showed
total
phenolic
(119.92±0.95
mg
GAE/g
exhibited
strongest
DPPH
radical
scavenging
activity
(69.41±0.55
%).
found
be
active
sample
against
ABTS
.+
(TEAC
0.257±0.012
mg/mL)
best
tyrosinase
inhibitor.
studied
demonstrated
a
low
inhibitory
effect
towards
acetylcholinesterase
possessed
cytotoxicity
concentration
range
10
300
μg/mL
toward
non‐cancer
(MDCK
II)
cancer
(A
549)
cells.