Hypopituitarism

The Lancet, Год журнала: 2024, Номер 403(10444), С. 2632 - 2648

Опубликована: Май 9, 2024

Язык: Английский

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Hypocalcemia in COVID-19: Prevalence, clinical significance and therapeutic implications

Reviews in Endocrine and Metabolic Disorders, Год журнала: 2021, Номер 23(2), С. 299 - 308

Опубликована: Апрель 13, 2021

COVID-19 extra-pulmonary features include several endocrine manifestations and these are becoming strongly clinically relevant in patients affected influencing disease severity outcomes.At the beginning of pandemic no population data on calcium levels were available April 2020 a first case severe acute hypocalcemia an Italian patient with SARS-CoV-2 infection was reported. Subsequently, studies reported as highly prevalent biochemical abnormality marked negative influence severity, inflammation thrombotic markers, mortality. Also high prevalence vertebral fractures worse respiratory impairment widespread vitamin D deficiency have been frequently observed, suggesting emerging "Osteo-Metabolic Phenotype" COVID-19.To date, potential pathophysiological factors hypothesized to play role determining including dependent viral mechanisms action, hypovitaminosis general population, chronic malnutrition during critical illness unbound unsaturated fatty acids inflammatory responses.Since is frequent finding hospitalized possibly predicting outcomes leading cardiovascular neurological complications if severe, it reasonable assess, monitor and, indicated, replace at hospital evaluation hospitalization.

Язык: Английский

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The Sexual Long COVID (SLC): Erectile Dysfunction as a Biomarker of Systemic Complications for COVID-19 Long Haulers

Sexual Medicine Reviews, Год журнала: 2021, Номер 10(2), С. 271 - 285

Опубликована: Ноя. 20, 2021

Язык: Английский

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Treatment of Cushing’s syndrome with osilodrostat: practical applications of recent studies with case examples

Pituitary, Год журнала: 2022, Номер 25(6), С. 795 - 809

Опубликована: Авг. 24, 2022

Abstract Endogenous Cushing’s syndrome (CS) is a rare endocrine condition frequently caused by tumor resulting in elevated cortisol levels. disease (CD) an adrenocorticotropic hormone–secreting pituitary adenoma the most common form of endogenous CS. Medical therapy for CD mostly used as second-line treatment after failed surgery or recurrence and comprises several pituitary-directed drugs, adrenal steroidogenesis inhibitors, glucocorticoid receptor blocker, some which are US Food Drug Administration (FDA)–approved this condition. The recent Pituitary Society consensus guidelines diagnosis management described osilodrostat, oral inhibitor 11β-hydroxylase, effective, FDA-approved medical CD. Because clinical experience outside trials limited, we provide here review published data about osilodrostat offer example case studies demonstrating practical considerations on use medication. Recommendations regarding provided following situations: specific assessments needed before initiation; monitoring insufficiency, hypokalemia, changes QTc; potential value slow up-titration patients with mild disease; managing temporary cessation who have acquired coronavirus 2019; increased testosterone levels women; exercising caution concomitant medication use; considering whether higher dose at nighttime might be beneficial; excess ectopic This highlights key situations that physicians may encounter when using provides recommendations optimal patient care treating CS, focus

Язык: Английский

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Pituitary and SARS CoV-2: An unremitting conundrum

Best Practice & Research Clinical Endocrinology & Metabolism, Год журнала: 2023, Номер 37(4), С. 101752 - 101752

Опубликована: Фев. 27, 2023

Язык: Английский

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The Growing Understanding of the Pituitary Implication in the Pathogenesis of Long COVID-19 Syndrome: A Narrative Review

Advances in respiratory medicine, Год журнала: 2024, Номер 92(1), С. 96 - 109

Опубликована: Фев. 14, 2024

Long COVID-19, also known as post-acute sequelae of SARS-CoV-2 infection, is a condition where individuals who have recovered from the acute phase COVID-19 continue to experience range symptoms for weeks or even months afterward. While it was initially thought primarily affect respiratory system, has become clear that can involve various organs and systems, including endocrine which includes pituitary gland. In context there growing understanding potential implications The virus directly gland, leading abnormalities in hormone production regulation. This result such fatigue, changes appetite, mood disturbances. persistent often debilitating following may be explained by deficiencies ACTH Growth Corticotropin insufficiency dysregulation body’s stress response lead prolonged feelings stress, disturbances patients. Simultaneously, somatotropin growth, muscle function, energy metabolism, potentially causing weakness, exercise intolerance, body composition. Recently, some authors suggested involvement gland Post Syndrome. exact mechanisms viral action on infected cells remain under discussion, but inflammatory autoimmune are implicated. aim our study will review main complications infection. Moreover, we explain possible persistence

Язык: Английский

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Long COVID and pituitary dysfunctions: a bidirectional relationship?

Pituitary, Год журнала: 2024, Номер 27(6), С. 955 - 969

Опубликована: Сен. 6, 2024

Язык: Английский

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Bilateral Optic Neuritis and Hypophysitis With Diabetes Insipidus 1 Month After COVID-19 mRNA Vaccine: Case Report and Literature Review

Journal of Investigative Medicine High Impact Case Reports, Год журнала: 2023, Номер 11

Опубликована: Янв. 1, 2023

Either optic neuritis (neuropathy) or hypopituitarism has been known to occur separately after COVID-19 vaccination. In this report, we describe the rare combination of hypophysitis and which occurred A 74-year-old woman began have thirst, polydipsia, polyuria, was diagnosed as central diabetes insipidus 1 month fourth mRNA vaccine. Head magnetic resonance imaging (MRI) disclosed thickened pituitary stalk enlarged gland with high contrast enhancement well absence high-intensity signals in posterior lobe on T1-weighted image, leading diagnosis lymphocytic hypophysitis. She desmopressin nasal spray until further 2 months later, when she developed bilateral neuritis, together gait disturbance, intention tremor upper extremities, urinary retention, constipation, abnormal sensation distal part lower moderate hemiplegia left side. Autoantibodies, including anti-aquaporin 4 (AQP4) anti-myelin oligodendrocyte glycoprotein (MOG), were all negative. showed multifocal spinal cord lesions MRI oligoclonal bands cerebrospinal fluid obtained by tap, so underwent steroid pulse therapy methylprednisolone tentative multiple sclerosis, resulting visual acuity recovery alleviation neurological symptoms. literature review, hypophysitis, mostly insipidus, reported 15 patients case reports before years pandemic. The vaccination would trigger onset patient.

Язык: Английский

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The osteo-metabolic phenotype of COVID-19: an update

Endocrine, Год журнала: 2022, Номер 78(2), С. 247 - 254

Опубликована: Июль 20, 2022

Язык: Английский

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Central diabetes insipidus: a late sequela of BNT162b2 SARS-CoV-2 mRNA vaccine?

BMC Endocrine Disorders, Год журнала: 2023, Номер 23(1)

Опубликована: Фев. 22, 2023

Abstract Background The development of an effective vaccine is a powerful tool to contain the global spread coronavirus disease 2019 (COVID-19). Still, it raises potential safety concerns about subsequent enhancement associated immunopathology. Increasing evidence shows that endocrine system, including hypophysis, may be involved in COVID-19. Moreover, occasional but increasing reports disorders involving thyroid have been reported after severe acute respiratory syndrome 2 (SARS-CoV-2) vaccine. Among them, few cases encompass pituitary. Here we report rare case central diabetes insipidus following SARS-CoV-2 vaccination. Case presentation We 59-year-old female patient with 25-year history Crohn's long-term remission, who presented sudden onset polyuria eight weeks administration mRNA Laboratory evaluation was consistent isolated insipidus. Magnetic resonance imaging displayed involvement infundibulum and posterior hypophysis. Eighteen months vaccination, she still under desmopressin treatment had stable pituitary stalk thickening on magnetic imaging. Although disease-associated hypophysitis has reported, scarce. In absence other recognizable causes hypophysitis, believe hypophysis our triggered by Conclusions potentially Further studies are needed understand better mechanisms underlying autoimmune endocrinopathies context COVID-19 infection

Язык: Английский

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