Vitamin D for the Prevention of Disease: An Endocrine Society Clinical Practice Guideline

The Journal of Clinical Endocrinology & Metabolism, Год журнала: 2024, Номер 109(8), С. 1907 - 1947

Опубликована: Июнь 3, 2024

Abstract Background Numerous studies demonstrate associations between serum concentrations of 25-hydroxyvitamin D (25[OH]D) and a variety common disorders, including musculoskeletal, metabolic, cardiovascular, malignant, autoimmune, infectious diseases. Although causal link 25(OH)D many disorders has not been clearly established, these have led to widespread supplementation with vitamin increased laboratory testing for in the general population. The benefit-risk ratio this increase use is clear, optimal intake role disease prevention remain uncertain. Objective To develop clinical guidelines (cholecalciferol [vitamin D3] or ergocalciferol D2]) lower risk individuals without established indications treatment testing. Methods A multidisciplinary panel experts, along experts guideline methodology systematic literature review, identified prioritized 14 clinically relevant questions related disease. randomized placebo-controlled trials populations (without an indication 25[OH]D testing), evaluating effects empiric administration throughout lifespan, as well select conditions (pregnancy prediabetes). defined “empiric supplementation” that (a) exceeds Dietary Reference Intakes (DRI) (b) implemented 25(OH)D. Systematic reviews queried electronic databases publications questions. Grading Recommendations, Assessment, Development, Evaluation (GRADE) was used assess certainty evidence guide recommendations. approach incorporated perspectives from patient representative considered values, costs resources required, acceptability feasibility, impact on health equity proposed process did assessment framework designed replace current DRI D. Results suggests children adolescents aged 1 18 years prevent nutritional rickets because its potential respiratory tract infections; those 75 older mortality; who are pregnant preeclampsia, intra-uterine mortality, preterm birth, small-for-gestational-age neonatal high-risk prediabetes reduce progression diabetes. Because doses included varied considerably trial participants were allowed continue their own D–containing supplements, unclear considered. For nonpregnant people than 50 whom indicated, via daily D, rather intermittent high doses. against above healthy adults younger years. No found support routine screening population, nor obesity dark complexion, there no clear defining target level required considered; thus, all judged that, most situations, inexpensive, feasible, acceptable both care professionals, negative effect equity. Conclusion over age, pregnant, prediabetes. Due scarcity natural food sources rich can be achieved through combination fortified foods supplements contain Based absence supportive evidence, indications. These recommendations meant DRIs do they apply Further research needed determine levels specific benefits.

Язык: Английский

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Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity

Nutrients, Год журнала: 2022, Номер 14(2), С. 284 - 284

Опубликована: Янв. 11, 2022

Vitamin D deficiency, characterized by low circulating levels of calcifediol (25-hydroxyvitamin D, 25D) has been linked to increased risk infections bacterial and viral origin. Innate immune cells produce hormonal calcitriol (1,25-dihydroxyvitamin 1,25D) locally from in response pathogen threat an immune-specific cytokine network. Calcitriol regulates gene expression through its binding the vitamin receptor (VDR), a ligand-regulated transcription factor. The hormone-bound VDR induces genes integral innate immunity including pattern recognition receptors, cytokines, most importantly antimicrobial peptides (AMPs). Transcription human AMP β-defensin 2/defensin-β4 (HBD2/DEFB4) cathelicidin peptide (CAMP) is stimulated bound promoter-proximal elements. HDB2/DEFB4 active form CAMP, LL-37, which amphipathic secondary structures, were initially for their antibacterial actively. Notably, signaling secretion activity vitro vivo, are associated with diverse indications impaired such as dental caries urinary tract infections. However, recent work also provided evidence that same AMPs components 1,25D-induced antiviral responses, those against etiological agent COVID-19 pandemic, SARS-CoV2 coronavirus. This review surveys vivo humans presents our current understanding potential mechanisms CAMP HBD2/DEFB4 contribute immunity.

Язык: Английский

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Vitamin D and Autoimmune Rheumatic Diseases

Biomolecules, Год журнала: 2023, Номер 13(4), С. 709 - 709

Опубликована: Апрель 21, 2023

Vitamin D is a steroid hormone with potent immune-modulating properties. It has been shown to stimulate innate immunity and induce immune tolerance. Extensive research efforts have that vitamin deficiency may be related the development of autoimmune diseases. observed in patients rheumatoid arthritis (RA) inversely disease activity. Moreover, implicated pathogenesis disease. also systemic lupus erythematosus (SLE). found activity renal involvement. In addition, receptor polymorphisms studied SLE. levels Sjogren’s syndrome, neuropathy lymphoma context syndrome. ankylosing spondylitis, psoriatic (PsA), idiopathic inflammatory myopathies. sclerosis. autoimmunity, it administered prevent reduce pain rheumatic disorders.

Язык: Английский

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rs7041 and rs4588 Polymorphisms in Vitamin D Binding Protein Gene (VDBP) and the Risk of Diseases

International Journal of Molecular Sciences, Год журнала: 2022, Номер 23(2), С. 933 - 933

Опубликована: Янв. 15, 2022

The purpose of the study was to investigate role vitamin D binding protein (VDBP, DBP) and its polymorphism in pathway human health. This narrative review shows latest literature on most popular diseases that have previously been linked VDBP. Vitamin plays a crucial metabolism, controlling phosphorus calcium homeostasis. bonds metabolites transports them target tissues. common polymorphisms VDBP gene are rs4588 rs7041, which located exon 11 domain III gene. rs7041 may be correlated with differences not only status serum but also metabolites. supports single nucleotide (SNPs) presents data showing correlations between variants important such as obesity, diabetes mellitus, tuberculosis, chronic obstructive pulmonary disease, others. In this review, we aim systematize knowledge regarding occurrence their relationship deficiencies, caused by Further research is required possible influence SNPs, modifications structure protein, organism. It mention studies do specific time year measure accurate metabolite levels, can misleading conclusions due seasonal nature D.

Язык: Английский

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QseB/QseC: a two-component system globally regulating bacterial behaviors

Trends in Microbiology, Год журнала: 2023, Номер 31(7), С. 749 - 762

Опубликована: Фев. 26, 2023

Язык: Английский

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Vitamin D influences gut microbiota and acetate production in zebrafish ( Danio rerio ) to promote intestinal immunity against invading pathogens

Gut Microbes, Год журнала: 2023, Номер 15(1)

Опубликована: Март 6, 2023

Although evidence has shown that vitamin D (VD) influences gut homeostasis, limited knowledge is available how VD regulates intestinal immunity against bacterial infection. In the present study, cyp2r1 mutant zebrafish, lacking capacity to metabolize VD, and zebrafish fed a diet devoid of were utilized as VD-deficient animal models. Our results confirmed expression antimicrobial peptides (AMPs) IL-22 was restrained susceptibility infection increased in zebrafish. Furthermore, induced AMP intestine by activating signaling, which dependent on microbiota. Further analysis uncovered abundance acetate-producer Cetobacterium reduced compared WT fish. Unexpectedly, promoted growth acetate production somerae under culture vitro. Importantly, treatment rescued suppressed β-defensins Finally, neutrophils contributed VD-induced conclusion, our study elucidated modulated microbiota composition short-chain fatty acids (SCFAs) intestine, leading enhanced immunity.

Язык: Английский

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Health Effects of Vitamin D Supplementation: Lessons Learned From Randomized Controlled Trials and Mendelian Randomization Studies

Journal of Bone and Mineral Research, Год журнала: 2023, Номер 38(10), С. 1391 - 1403

Опубликована: Июль 22, 2023

ABSTRACT Vitamin D plays an important role in calcium homeostasis and many cellular processes. Although vitamin supplements are widely recommended for community-dwelling adults, definitive data on whether these benefit clinically skeletal extraskeletal outcomes have been conflicting. observational studies effects of musculoskeletal may be confounded by reverse causation, randomized controlled (RCTs) Mendelian randomization (MR) can help to elucidate causation. In this review, we summarize the recent findings from large RCTs and/or MR bone health risk fractures, falls, cancer, cardiovascular disease, disorders immune system, multiple sclerosis, mortality adults. The primary analyses indicate that supplementation does not decrease loss, cancer incidence, hypertension, or generally healthy populations. Large meta-analyses suggest effect supplemental mortality. existence benefits supplementations best documented system especially people with poor status, autoimmune diseases, sclerosis. Accumulating evidence indicates reduce all-cause These findings, mostly D–replete populations, do apply older adults residential communities deficiency osteoporosis. focus should shift widespread use populations targeted select individuals, good nutritional approaches, elimination globally. © 2023 American Society Bone Mineral Research (ASBMR).

Язык: Английский

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Impact of vitamin D supplementation on the clinical outcomes of COVID-19 pneumonia patients: a single-center randomized controlled trial

BMC Complementary Medicine and Therapies, Год журнала: 2024, Номер 24(1)

Опубликована: Фев. 21, 2024

Vitamin D supplementation for infectious diseases has been discussed, but its role in COVID-19 is unclear. Therefore, this study examined the clinical outcomes of pneumonia patients who received vitamin supplementation.

Язык: Английский

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Machine learning-based prediction of vitamin D deficiency: NHANES 2001-2018

Frontiers in Endocrinology, Год журнала: 2024, Номер 15

Опубликована: Фев. 16, 2024

Background Vitamin D deficiency is strongly associated with the development of several diseases. In current context a global pandemic vitamin deficiency, it critical to identify people at high risk deficiency. There are no prediction tools for predicting in general community population, and this study aims use machine learning predict using data that can be obtained through simple interviews community. Methods The National Health Nutrition Examination Survey 2001-2018 dataset used analysis which randomly divided into training validation sets ratio 70:30. GBM, LR, NNet, RF, SVM, XGBoost methods construct models their performance evaluated. best performed model was interpreted SHAP value further online web calculator. Results were 62,919 participants enrolled study, all included 2 years old above, 20,204 (32.1%) had constructed by each method evaluated AUC as primary evaluation statistic ACC, PPV, NPV, SEN, SPE, F1 score, MCC, Kappa, Brier score secondary statistics. Finally, XGBoost-based has near-perfect performance. summary plot values shows top three important features race, age, BMI. An calculator based on easily quickly Conclusion tool performs flawlessly highly accurate populations.

Язык: Английский

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A Comprehensive Review on the Beneficial Roles of Vitamin D in Skin Health as a Bio-Functional Ingredient in Nutricosmetic, Cosmeceutical, and Cosmetic Applications

Applied Sciences, Год журнала: 2025, Номер 15(2), С. 796 - 796

Опубликована: Янв. 15, 2025

Vitamin D, also called the “sunshine” vitamin, has gained great attention recently due to observed high percentage of worldwide population being deficient in this essential bioactive vitamin. Primarily, vitamin D was known for its important role bone health. Nevertheless, recent research shown importance brain, heart, muscles, immune system, and skin health, distinct bio-functionality almost every tissue human body. Therefore, deficiency been highly correlated with multiple diseases, including dermatologically associated ones. Moreover, different methodologies are applied synthesize while main sources plasma levels factors that can cause adverse modifications multiple. Further upon exhibited notable against such as psoriasis, atopic dermatitis, vitiligo, acne, rosacea. In article, a critical review most relevant significant information regarding relationship between health is thoroughly conducted, emphasis given potential uses benefits several cosmetic applications. Current status, limitations, future perspectives potent extensively discussed.

Язык: Английский

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