Review on Synthesis of Bio-active Coumarin-fused Heterocyclic Molecules
Current Organic Chemistry,
Год журнала:
2020,
Номер
24(22), С. 2566 - 2587
Опубликована: Июль 10, 2020
The
literature
survey
reveals
that
the
individual
coumarin
and
heterocyclic
molecules
have
biological
pharmaceutical
activities.
Moreover,
integrated
coumarinfused
compounds
shown
interesting
physiochemical
properties
thus,
designing
development
of
coumarin-fused
are
great
interest
in
field
synthetic
organic
chemistry.
Several
been
synthesized
by
using
different
strategies
such
as
multistep
method,
one-pot
multi-component
protocol,
coupling
condensation
method.
wide
applications
stimulated
among
researchers
to
develop
methodologies
for
synthesis
novel
fused
molecules.
As
a
consequence,
several
research
articles,
papers
review
articles
published
literature.
In
this
article,
we
presented
various
methods
class
their
chemical,
optical,
other
useful
applications.
Язык: Английский
Ce(IV) immobilized on halloysite nanotube–functionalized dendrimer (Ce(IV)–G2): A novel and efficient dendritic catalyst for the synthesis of pyrido[3,2‐c]coumarin derivatives
Applied Organometallic Chemistry,
Год журнала:
2020,
Номер
34(11)
Опубликована: Июль 24, 2020
In
this
study,
a
new
and
stable
Ce(IV)
immobilized
on
halloysite
nanotube–functionalized
dendrimer
was
designed,
synthesized,
characterized
using
Fourier‐transform
infrared,
elemental
analysis,
thermogravimetric
field
emission
scanning
electron
microscopy,
microscopy–energy
dispersive
X‐ray
spectroscopy,
transmission
dynamic
light
scattering,
Brunauer–Emmett–Teller,
inductively
coupled
plasma
optical
spectroscopy
techniques.
This
catalyst
efficiently
used
for
the
one‐pot,
single‐step
multicomponent
synthesis
of
pyrido[3,2‐
c
]coumarins
from
4‐aminocoumarin,
aldehydes,
aryl
ketones.
The
efficiency
selectivity
catalytic
system
were
also
evaluated
terminal/internal
alkynes
instead
respect,
regioselectivity
products
successfully
assigned
by
crystallographic
analysis.
All
these
reactions
best
performed
under
solvent‐free
conditions
in
presence
only
0.28
mol%
catalyst,
such
one‐pot
is
reported
first
time.
It
worth
noting
that
short
reaction
path
variety
along
with
excellent
reusability
dendritic
makes
method
economically
environmentally
attractive.
Язык: Английский
A novel nanomagnetic solid acid catalyst for the synthesis of new functionalized bis‐coumarin derivatives under microwave irradiations in green conditions
Applied Organometallic Chemistry,
Год журнала:
2020,
Номер
34(7)
Опубликована: Март 16, 2020
In
this
study,
a
novel,
green,
environmentally
friendly
and
magnetically
heterogeneous
catalyst
based
on
the
immobilization
of
sulfosalicylic
acid
onto
Fe
3
O
4
nanoparticles
(Fe
@sulfosalicylic
MNPs)
is
reported.
The
bis‐coumarin
analogs
were
synthesized
in
high
yield
using
reaction
1
equivalent
aryl
aldehydes
with
2
equivalents
4‐hydroxycoumarin
water
under
microwave
irradiation
conditions.
Scanning
electron
microscopy,
transmission
energy‐dispersive
X‐ray
spectroscopy,
diffraction,
thermogravimetric
analysis,
dynamic
light
scattering,
vibrating
sample
magnetometry,
Fourier
transform
infrared
UV–visible
absorption,
Brunauer‐Emmett‐Teller
(BET)
techniques
confirmed
successful
synthesis
catalyst.
main
attractive
characteristics
presented
green
protocol
are
very
short
times
(10–15
min),
excellent
yields,
avoidance
hazardous
or
toxic
reagent
solvents.
Thermal
durability,
easy
separation,
reusability
important
advantages
new
comparison
to
other
catalysts.
Язык: Английский
4-Aminocoumarin Derivatives as Multifaceted Building Blocks for the Development of Various Bioactive Fused Coumarin Heterocycles: A Brief Review
Current Organic Chemistry,
Год журнала:
2022,
Номер
26(17), С. 1585 - 1614
Опубликована: Сен. 1, 2022
Abstract:
Aminocoumarins
are
found
to
be
present
in
many
natural
products,
pharmaceuticals,
and
organic
materials.
These
derivatives
demonstrate
numerous
biological
activities
including
DNA
gyrase,
anti-proliferative
anti-breast
cancer
activities.
Among
the
allaminocoumarin
derivatives,
4-aminocoumarin
have
been
reported
exhibit
anticancer
anti-fungal
properties.
4-Aminocoumarins
their
important
precursors
for
synthesis
of
coumarin
fused
N-heterocycles.
Due
presence
an
amino
group
as
well
enamine
carbon,
it
is
very
reactive
towards
electrophiles
most
cases,
has
a
higher
tendency
cyclize
immediately
by
various
reaction
path
ways
provides
heterocyclic
products.
Unlike
other
aromatic
amines,
did
not
give
any
Schiff
base
on
with
aldehydes
or
ketones.
Lamellarins,
ningalin
A,
B,
schumanniophytin,
santiagonamine,
goniothaline,
polyneomarline
C
N-heterocycles
show
excellent
activities,
antitumor,
reversal
multidrug
resistance,
anti-HIV,
wound
healing,
anti-malarial,
anti-hepatitis,
anti-syphilis
The
synthesized
display
Topoisomerases
I
inhibitory,
DYRK1A
anti-cancer
Most
syntheses
pyrrolo/imidazolo/indolo[3,2-c]coumarin,
pyrido/quinolino[3,2-c]coumarins,
pyrimidino[
c]coumarin
oxazino[c]coumarin
easily
from
4-aminocoumarin.
This
paper
reviews
research
data
literature
bioactive
heterocycles
using
over
period
2-3
decades.
It
covers
synthetic
applicability
development
5-,
6-,
8-membered
ring
via
classical
protocols,
microwavemediated
reactions,
organo-catalyzed
transition
metal-catalyzed
green
protocols.
Язык: Английский
The synthesis, biological evaluation, and fluorescence study of 3-aminocoumarin and their derivatives: a brief review
Monatshefte für Chemie - Chemical Monthly,
Год журнала:
2023,
Номер
154(1), С. 1 - 31
Опубликована: Янв. 1, 2023
Язык: Английский
A Brief Review on the Design, Synthesis and Biological Evaluation of Pyrazolo[ c ]coumarin Derivatives
Polycyclic aromatic compounds,
Год журнала:
2023,
Номер
44(2), С. 818 - 859
Опубликована: Фев. 23, 2023
Both
pyrazole
and
coumarin
moiety
are
important
scaffolds
for
their
natural
occurrences
as
well
a
broad
spectrum
of
pharmaceutical
properties.
When
fuses
with
containing
diverse
functionality,
synergic
effect
may
be
observed
in
the
field
medicinal
material
chemistry.
Owing
to
various
functionality
on
title
compounds,
they
possess
fantastic
biological
properties
including
antimicrobial,
antiproliferative,
CpIMPDH
inhibition,
α-glucosidase
selective
hCA
IX
inhibition
anticancer
activities.
Some
architectural
pyrazolo[c]coumarin
derivatives
were
reported
used
bipolar
host
materials
blue
TADF-OLEDs.
For
these
reasons,
special
attention
has
been
paid
researchers
searching
new,
greener
efficient
protocols
design
synthesis
pyrazolo[c]coumarins
evaluate
This
paper
reviews
research
data
literature
synthetic
strategies
structurally
designed
derivatives.
Furthermore,
synthesized
compounds
described
by
highlighting
mode
interactions
different
cells
enzymes.
Язык: Английский
An Overview of the Synthesis of 3,4-Fused Pyrrolocoumarins of Biological Interest
Molecules,
Год журнала:
2024,
Номер
29(12), С. 2748 - 2748
Опубликована: Июнь 9, 2024
3,4-Fused
pyrrolocoumarins,
synthetically
prepared
or
naturally
occurring,
possess
interesting
biological
properties.
In
this
review,
the
synthetic
strategies
for
synthesis
of
title
compounds
are
presented
along
with
their
activities.
Two
routes
followed
that
synthesis.
one,
pyrrole
ring
is
formed
from
coumarin
derivatives,
such
as
aminocoumarins
other
coumarins.
approach,
pyranone
moiety
built
an
existing
derivative
through
simultaneous
formation
and
frameworks.
The
above
syntheses
achieved
via
1,3-dipolar
cycloaddition
reactions,
Michael
reaction,
aza-Claisen
rearrangement
multi-component
reactions
(MCR),
well
metal-catalyzed
reactions.
Pyrrolocoumarins
present
cytotoxic,
antifungal,
antibacterial,
α-glucosidase
inhibition,
antioxidant,
lipoxygenase
(LOX)
fluorescent
activities,
benzodiazepine
receptor
ability.
Язык: Английский
Nanoarchitectonics with Positionally Isomeric Coumarin Carbamates: Structure‐Gelation Study, F− Recognition, Dye Removal and Excellent Oil‐Spill Recovery
ChemPlusChem,
Год журнала:
2022,
Номер
87(9)
Опубликована: Авг. 25, 2022
Coumarin
carbamates
with
cholesteryl
group
1
and
2
have
been
designed,
synthesized
characterized.
The
isomeric
compounds
show
different
gelation
behaviors
in
organic
solvents
such
as
toluene
CH3
CN.
Rheological
studies
reveal
the
viscoelastic
properties
of
gels.
Gels
isomers
differ
morphology.
While
an
intertwined
fibre-like
structure
is
noted
for
gel
1,
rod
like
fibres
are
observed
2.
positional
alteration
carbamate
around
coumarin
changes
polarity
hence
influences
packing
molecules
to
establish
3D
networks
formation
explained
by
DFT
study.
multiple
applications
attributes.
Toluene
found
be
F-
-responsive
undergoes
gel-to-sol
phase
transition
due
disruption
intermolecular
hydrogen
bonding
through
deprotonation.
Under
condition,
anion
stable.
Compound
also
shows
measurable
interaction
over
other
anions
CN
interpreted
UV-vis
emission
spectral
changes.
Based
on
phase-selective
(PSG)
property,
both
deployed
remove
cationic
dye
from
water.
Further,
only
gelator
useful
oil
spill
recovery,
whereas
isomer
not
suitable
this
regard.
Язык: Английский
Direct and Regioselective C−H Selenylation of 4‐Aminocoumarin Derivatives Mediated by Selectfluor®
ChemistrySelect,
Год журнала:
2023,
Номер
8(9)
Опубликована: Фев. 28, 2023
Abstract
A
mild
and
regioselective
approach
to
the
direct
selenylation
of
4‐(
N
‐substituted‐amino)‐
2H
‐chromen‐2‐ones
employing
Selectfluor®
diorganyl
diselenides
has
been
developed.
The
reactions
were
carried
out
under
metal‐free
conditions,
without
need
for
special
devices,
using
NaHCO
3
as
a
base
at
room
temperature
air.
This
suitable
wide
substrate
scope
affording
3‐selenyl‐4‐(
in
good
excellent
yields.
Язык: Английский