Copper toxicity and deficiency: the vicious cycle at the core of protein aggregation in ALS

Frontiers in Molecular Neuroscience, Год журнала: 2024, Номер 17

Опубликована: Июль 9, 2024

The pathophysiology of ALS involves many signs a disruption in copper homeostasis, with both excess free levels and functional deficiency likely occurring simultaneously. This is crucial, as important physiological functions are performed by cuproenzymes. While it unsurprising that symptoms related to deficiency, resulting vascular, antioxidant system mitochondrial oxidative respiration deficiencies, there also toxicity such ROS generation enhanced protein aggregation. We discuss how plays key role proteostasis interacts either directly or indirectly the aggregate-prone proteins implicated ALS, TDP-43, C9ORF72, SOD1 FUS well effect their aggregation on homeostasis. suggest loss cuproprotein function at core pathology, condition driven combination unbound can initiate and/or accelerate could trigger positive feedback cycle whereby aggregates other chain reaction eventually captures elements proteostatic mechanisms place counteract them. end result an abundance aggregated non-functional cuproproteins chaperones alongside depleted intracellular stores, general lack cuproenzyme function. then possible aetiology illustrate strong risk factors including environmental toxins BMAA heavy metals functionally behave promote disturb metabolism drives this vicious sporadic ALS. From synthesis, we propose restoration balance using delivery agents chaperones/chaperone mimetics, perhaps conjunction neuroprotective amino acid serine, promising strategy treatment incurable disease.

Язык: Английский

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Airborne Cyanobacterial Toxins and Their Links to Neurodegenerative Diseases

Molecules, Год журнала: 2025, Номер 30(11), С. 2320 - 2320

Опубликована: Май 26, 2025

Cyanobacteria can produce a wide range of toxins which have acute and chronic adverse health effects. Affecting variety mammalian systems, they are generally characterized according to their mode action the organs affected. Cyanobacterial neurotoxins one cyanotoxin class that negatively affect human health, representatives other cyanotoxins classes increasingly showing neurotoxic Of various exposure routes cyanobacterial toxins, significance airborne inhalation route requires much greater clarity understanding. People may be exposed mixtures through sprays dust, along with potential directly enter central nervous system when crossing blood-brain barrier. This review aims summarize current state knowledge concerning neurotoxins, research gaps, effects, need for management practices protect animal health.

Язык: Английский

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Accumulation of microcystin toxin in irrigation water and alfalfa (Medicago sativa) forage plant, and assessing the potential risk to animal health

Chemosphere, Год журнала: 2024, Номер 364, С. 143248 - 143248

Опубликована: Сен. 1, 2024

Язык: Английский

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Subcellular distribution of the β-N-methylamino-L-alanine-containing proteins in marine diatoms

Algal Research, Год журнала: 2024, Номер 83, С. 103708 - 103708

Опубликована: Сен. 10, 2024

Язык: Английский

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Cyanobacterial Toxins: Foes from the Water

IntechOpen eBooks, Год журнала: 2024, Номер unknown

Опубликована: Авг. 13, 2024

This chapter is an introduction to the cyanobacterial (blue-green algae) ecology, with main aim of better understanding design blooms and cyanotoxins in natural environments. Cyanobacteria are a diverse group photoautotrophic organisms where their dominance represents significant indicator water quality. Several genera have potential produce toxins—hepatotoxins (microcystins, nodularins), cytotoxins (cylindrospermopsin), neurotoxins (saxitoxins, anatoxins, BMAA), dermatotoxins (lyngbyatoxin), irritant toxins (lipopolysaccharide endotoxins). provides concise achievable summary negative impact on health environment, supplemented tables schemes that illustrate ecology cyanobacteria, different types cyanotoxins, issues. The exposure routes also discussed, which particularly important due increasing eutrophication water. It emphasized climate change, global warming, increased responsible for blooms. As consequence, risk they pose likely grow; accompanied by ability toxins, cyanobacteria represent imminent danger human animal health. One primary goals future research should be share knowledge about develop solutions early detection prevention bloom occurrence.

Язык: Английский

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A systematic review on analytical methods of the neurotoxin β-N-methylamino-L-alanine (BMAA), and its causative microalgae and distribution in the environment

Chemosphere, Год журнала: 2024, Номер 366, С. 143487 - 143487

Опубликована: Окт. 1, 2024

Язык: Английский

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