Interactions between the intestinal microbiota and drug metabolism – Clinical implications and future opportunities

Biochemical Pharmacology, Год журнала: 2025, Номер unknown, С. 116809 - 116809

Опубликована: Фев. 1, 2025

Язык: Английский

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Evidence of synbiotic potential of oat beverage enriched with inulin and fermented by L. rhamnosus LR B in a dynamic in vitro model of human colon

Food Research International, Год журнала: 2025, Номер unknown, С. 116489 - 116489

Опубликована: Апрель 1, 2025

Язык: Английский

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Roles of Probiotics, Prebiotics, and Postbiotics in B-cell mediated Immune Regulation

Journal of Nutrition, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 1, 2024

Язык: Английский

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Chronic constipation: focus on microbiome-targeted therapies with prebiotics, probiotics, and synbiotics

Almanac of Clinical Medicine, Год журнала: 2024, Номер 52(5), С. 280 - 296

Опубликована: Ноя. 4, 2024

Chronic constipation is a global medical, social, and economic problem due to its negative impact on patients’ quality of life increased risk colorectal cancer, cardiovascular cerebrovascular disorders. The gut microbiota plays an important role in the pathophysiology through interplay with immune system, enteral central nervous representing promising therapeutic target. Gut dysbiosis patients characterized by reduced relative numbers bacteria producing lactate (Lactobacillaceae, Bifidobacteriaceae) butyrate (Lachnospiraceae, Oscillospiraceae), as well those hydrogen sulfide (Desulfovibrionaceae) methanogenic archaea (Methanobacteriaceae). leading pathogenetic mechanism related intestinal chronic constipation, can be microbial metabolic abnormalities (metabolic dysbiosis) altered production short-chain fatty acid, methane, sulfide, tryptophan metabolites abnormal bile acid biotransformation. It has been proven that dysbiotic microbiome play which allows for use prebiotics, probiotics, synbiotics effective microbiome-modulating therapy constipation. determines effectiveness (prebiotics, synbiotics) this syndrome. Inulin most studied preboitic; it soluble food fiber markedly contributes regulation microbiota, stimulates growth beneficial bacteria, anti-inflammatory metabolites. normalized function increasing stool frequency, softening stool, reducing transit time. In addition, inulin modulates response impacts absorption minerals, appetite, satiety. Treatment probiotics also associated time, compared controls. According systematic review meta-analysis 30 randomized controlled trials, only Bifidobacterium lactis strains (but not other probiotics) significantly increase frequencies adults. Clinical studies have shown targeted probiotic HN019 low (≤ 3 per week) frequency up 4.7–5.0 week, reduce time rate functional gastroenterological symptoms adults Beyond clinical effects, leads changes bifidobacteria decreasing enterobacteria numbers. results trials confirm importance synbiotic correction all improve fecal consistency, prevent disorders Synbiotics, such combination inulin, properties both complementary synergic synbiotic, may greatest potential outcomes or prebiotics used alone.

Язык: Английский

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Novel lactic acid bacteria with anti-hyperglycaemic properties:In vitro screening and probiotic assessment

Food Bioscience, Год журнала: 2024, Номер unknown, С. 105696 - 105696

Опубликована: Дек. 1, 2024

Язык: Английский

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