Molecules, Год журнала: 2024, Номер 29(24), С. 5934 - 5934

Опубликована: Дек. 16, 2024

Targeted metabolomics and lipidomics are increasingly utilized in clinical research, providing quantitative comprehensive assessments of metabolic profiles that underlie physiological pathological mechanisms. These approaches enable the identification critical metabolites alterations essential for accurate diagnosis precision treatment. Mass spectrometry, combination with various separation techniques, offers a highly sensitive specific platform implementing targeted settings. Nevertheless, challenges persist areas such as sample collection, quantification, quality control, data interpretation. This review summarizes recent advances lipidomics, emphasizing their applications research. Advancements, including microsampling, dynamic multiple reaction monitoring, integration ion mobility mass highlighted. Additionally, discusses importance standardization harmonization successful implementation.

Язык: Английский