Journal of Pineal Research,
Год журнала:
2022,
Номер
74(2)
Опубликована: Ноя. 26, 2022
Abstract
With
the
rapid
change
of
people's
lifestyle,
more
childbearing
couples
live
with
irregular
schedules
(i.e.,
staying
up
late)
and
suffer
from
decreased
fertility
abortion,
which
can
be
caused
by
luteal
phase
defect
(LPD).
We
used
continuous
light‐exposed
mice
as
a
model
to
observe
whether
light
exposure
may
affect
luteinization
function.
showed
that
level
progesterone
in
serum
reduced
(
p
<
.001),
number
corpus
luteum
(CL)
.01),
expressions
luteinization‐related
genes
Lhcgr
,
Star
Ptgfr
Runx2
),
clock
Clock
Per1
Mt1
were
downregulated
.05)
ovaries
exposed
light,
suggesting
induces
defects
functions.
Strikingly,
injection
melatonin
(3
mg/kg)
could
improve
functions
mice.
Moreover,
we
found
that,
after
2
h
hCG
injection,
pERK1/2
ovary
group,
but
increased
administration
LPD
through
activating
ERK1/2
pathway.
In
summary,
our
data
demonstrate
affects
function,
rescued
melatonin.
Frontiers in Endocrinology,
Год журнала:
2024,
Номер
14
Опубликована: Янв. 17, 2024
Reproductive
system
diseases
pose
prominent
threats
to
human
physical
and
mental
well-being.
Besides
being
influenced
by
genetic
material
regulation
changes
in
lifestyle,
the
occurrence
of
these
is
closely
connected
exposure
harmful
substances
environment.
Endocrine
disrupting
chemicals
(EDCs),
characterized
hormone-like
effects,
have
a
wide
range
influences
on
reproductive
system.
EDCs
are
ubiquitous
natural
environment
present
industrial
everyday
products.
Currently,
thousands
been
reported
exhibit
endocrine
this
number
likely
increase
as
testing
for
potential
has
not
consistently
required,
obtaining
data
limited,
partly
due
long
latency
many
diseases.
The
ability
avoid
EDCs,
especially
those
artificially
synthesized
origin,
increasingly
challenging.
While
can
be
divided
into
persistent
non-persistent
depending
their
degree
degradation,
recent
uptick
research
studies
area,
we
chosen
focus
pertaining
detrimental
effects
health
several
that
widely
encountered
daily
life
over
past
six
years,
specifically
bisphenol
A
(BPA),
phthalates
(PAEs),
polychlorinated
biphenyls
(PCBs),
parabens,
pesticides,
heavy
metals,
so
on.
By
focusing
impact
hypothalamic-pituitary-gonadal
(HPG)
axis,
which
leads
development
diseases,
review
aims
provide
new
insights
molecular
mechanisms
EDCs’
damage
encourage
further
in-depth
clarify
potentially
EDC
through
various
other
mechanisms.
Ultimately,
it
offers
scientific
basis
enhance
risk
management,
an
endeavor
significant
societal
importance
safeguarding
health.
Environment International,
Год журнала:
2022,
Номер
167, С. 107446 - 107446
Опубликована: Авг. 1, 2022
Bisphenol
A
(BPA)
as
an
endocrine
disrupting
chemical
has
been
shown
to
alter
reproductive
function,
but
little
is
known
on
its
analogues
such
bisphenol
F
(BPF)
and
S
(BPS)
with
increasing
usage
exposure.
To
explore
the
associations
between
exposures
BPA,
BPF
BPS
serum
hormones
among
reproductive-aged
Chinese
men.
We
measured
concentrations
in
repeated
urine
samples
multiple
collected
from
462
men
attending
infertility
clinic
Wuhan,
China.
Linear
regression
models
were
applied
assess
averaged
urinary
levels
hormone
concentrations,
restricted
cubic
spline
(RCS)
further
utilized
potential
non-linear
associations.
also
examined
modifying
effects
by
age
body
mass
index
(BMI).
There
was
evidence
of
BPA
exposure
altered
hormones.
However,
we
found
that
elevated
negative
estrogen
(E2)
E2/T
(total
testosterone)
ratio
(all
P
for
trends
<
0.05),
negatively
associated
SHBG
(P
trend
=
0.09).
Based
RCS
models,
these
linear
except
confirmed.
In
stratified
analyses,
relation
reduced
E2
more
pronounced
aged
>
30
years,
whereas
their
≤
30.
Also,
association
FSH
only
emerged
BMI
≥
24
kg/m2
interaction
0.03).
male
E2,
levels,
varied
BMI.
Toxics,
Год журнала:
2025,
Номер
13(3), С. 164 - 164
Опубликована: Фев. 26, 2025
Bisphenols
(BPs)
are
a
group
of
organic
compounds
used
extensively
in
plastics,
coatings,
and
epoxy
resins;
they
have
been
concern
recently
due
to
their
endocrine-disrupting
effects.
Among
these,
bisphenol
A
(BPA)
is
the
most
studied.
Regulatory
measures,
such
as
ban
on
BPA
use
baby
bottles
by
European
Union
its
restricted
thermal
paper,
reflect
growing
awareness
health
risks
BPA.
To
mitigate
these
risks,
analogs
S
(BPS),
F
(BPF),
others
(BPAF,
BPAP,
BPB,
BPP,
BPZ)
developed
alternatives.
Despite
intended
safety,
detected
environmental
media,
including
indoor
dust
receipt
well
human
biological
samples.
Studies
report
presence
urine
at
levels
comparable
BPA,
with
BPS
BPF
found
78%
55%
samples,
respectively.
In
addition,
BPs
follicular
fluid
(FF)
concentrations
that
could
exert
some
paracrine
effects
ovarian
function
reproductive
health.
With
increased
global
production
BPs,
occupational
exposure
contamination
also
increase.
This
review
summarizes
what
currently
known
about
ovary
mechanisms
which
PBs
toxicity,
particular
focus
oogenesis,
folliculogenesis,
steroidogenesis.
Further,
this
emphasizes
influence
functions
need
for
further
biosafety
evaluations.
Frontiers in Endocrinology,
Год журнала:
2023,
Номер
14
Опубликована: Окт. 3, 2023
Maternal
endocrine
homeostasis
is
vital
to
a
successful
pregnancy,
regulated
by
several
hormones
such
as
human
chorionic
gonadotropin,
estrogen,
leptin,
glucocorticoid,
insulin,
prostaglandin,
and
others.
Endocrine
stress
during
pregnancy
can
modulate
nutrient
availability
from
mother
fetus,
alter
fetoplacental
growth
reproductive
functions.
disrupters
bisphenols
(BPs)
phthalates
are
exposed
in
our
daily
life's
highest
volume.
Therefore,
they
extensively
scrutinized
for
their
effects
on
metabolism,
steroidogenesis,
insulin
signaling,
inflammation
involving
obesity,
diabetes,
the
system.
BPs
have
structural
similarity
17-β
estradiol
ability
bind
an
agonist
or
antagonist
estrogen
receptors
elicit
adverse
response
function
of
While
adults
negate
these
endocrine-disrupting
chemicals
(EDCs),
fetuses
do
not
equip
themselves
with
enzymatic
machinery
catabolize
conjugates.
EDC
exposure
makes
developmental
window
vulnerable
programming
utero
.
On
one
hand
prenatal
impair
structure
ovary
uterus,
resulting
placental
vascular
defects,
inappropriate
expression
angiogenic
factors
due
altered
hypothalamic
response,
transporters,
epigenetic
changes
associated
maternal
stress.
other,
affect
offspring's
metabolic,
functions
altering
programming.
This
review
highlights
latest
development
metabolic
modulations
estrogenic
mimic
subcellular
transgenerational
its
fetal
growth,
size,
&
Clinics,
Год журнала:
2023,
Номер
78, С. 100310 - 100310
Опубликована: Янв. 1, 2023
PCOS
is
an
endocrine
disorder
characterized
by
chronic
anovulation,
hyperandrogenism,
and
polycystic
ovaries.
Its
etiology
uncertain.
It
debated
whether
BPA
would
be
a
component
of
the
environmental
factor
in
PCOS.
Contamination
can
occur
from
food
packaging
(exposure
during
diet)
through
skin
absorption
and/or
inhalation.
transferred
to
fetus
via
placenta
or
infant
breast
milk,
it
found
follicular
fluid,
fetal
serum,
amniotic
fluid.
The
phenolic
structure
allows
interact
with
Estrogen
Receptors
(ERs)
genomic
signaling,
which
binds
nuclear
ERα
Erβ,
nongenomic
signaling
binding
membrane
ERs,
prompting
rapid
intense
response.
With
daily
constant
exposure,
BPA's
tendency
bioaccumulate
its
ability
activate
pathways
alter
women's
metabolic
reproductive
function,
leading
insulin
resistance,
obesity,
atherogenic
dyslipidemia,
inflammatory
state,
anovulation
favoring
harmful
changes
caused
passed
on
future
generations
without
need
for
additional
exposure
because
epigenetic
modifications.
Not
only
high
levels
produce
effects,
but
at
low
levels,
may
when
occurs
most
vulnerable
periods,
such
as
neonatal
well
prepubertal
age
causing
early
accumulation
body.
Learning
how
participates
pathogenesis
poses
challenge
further
studies
should
conducted.
Journal of Clinical Medicine,
Год журнала:
2022,
Номер
11(23), С. 7227 - 7227
Опубликована: Дек. 5, 2022
Humans
interfere
with
a
variety
of
endocrine
disruptors
on
daily
basis,
which
may
result
in
adverse
health
effects.
Among
them,
Bisphenol-A
(BPA)
is
the
most
debated
disruptor,
despite
being
widely
studied,
regarding
its
effects
fertility.
The
aim
this
review
was
to
investigate
interrelation
BPA
and
female
PubMed
(Medline)
searched
from
2013
until
2022
identify
epidemiological
studies
that
report
association
fertility
parameters,
vitro
fertilization
(IVF)
outcomes,
polycystic
ovarian
syndrome
(PCOS)
endometriosis.
Regarding
general
fertility,
an
inverse
between
reserve
markers,
namely
antral
follicle
count
(AFC)
anti-Müllerian
hormone
(AMH).
estradiol
(E2)
levels
did
not
correlate
significantly
majority
studies.
No
definite
conclusions
can
be
reached
IVF
endpoints
or
Lastly,
higher
prevalence
PCOS
women
concentrations,
although
no
casualty
has
been
proven.
Although
fail
reach
conclusion
impact
there
accumulating
evidence
suggesting
negative
role
reproductive
health.
