Altered infective competence of the human gut microbiome in COVID-19

Microbiome, Год журнала: 2023, Номер 11(1)

Опубликована: Март 9, 2023

Infections with SARS-CoV-2 have a pronounced impact on the gastrointestinal tract and its resident microbiome. Clear differences between severe cases of infection healthy individuals been reported, including loss commensal taxa. We aimed to understand if microbiome alterations functional shifts are unique or common effect COVID-19. used high-resolution systematic multi-omic analyses profile gut in asymptomatic-to-moderate COVID-19 compared control group.We found striking increase overall abundance expression both virulence factors antimicrobial resistance genes Importantly, these encoded expressed by taxa from families such as Acidaminococcaceae Erysipelatoclostridiaceae, which we be enriched COVID-19-positive individuals. also an enrichment betaherpesvirus rotavirus C controls.Our identified altered increased infective competence patients. Video Abstract.

Язык: Английский

---

A Review of Hyperglycemia in COVID-19

Cureus, Год журнала: 2023, Номер unknown

Опубликована: Апрель 12, 2023

Diabetes mellitus (DM) is one of the most common chronic metabolic disorders worldwide, which increases risk and opportunistic infections. Following coronavirus disease 2019 (COVID-19) pandemic, a higher incidence rate, more severe forms disease, exacerbation hyperglycemia its complications have been observed in patients with DM. Moreover, stress-induced has many hospitalized nondiabetic after contracting COVID-19. Hyperglycemia worsens prognosis both diabetic patients. In this study, mechanism new-onset or hyperglycemia, effect treatments used for COVID-19 on importance appropriate method blood glucose (blood sugar (BS)) control during possible fate recovery from to some extent expressed.

Язык: Английский

---

Anti-viral drug discovery against monkeypox and smallpox infection by natural curcumin derivatives: A Computational drug design approach

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Март 22, 2023

Background In the last couple of years, viral infections have been leading globe, considered one most widespread and extremely damaging health problems causes mortality in modern period. Although several are discovered, such as SARS CoV-2, Langya Henipavirus, there only a limited number discoveries possible antiviral drug, vaccine that even received authorization for protection human health. Recently, another virial infection is infecting worldwide (Monkeypox, Smallpox), which concerns pharmacists, biochemists, doctors, healthcare providers about epidemic. Also, currently no specific treatment available against Monkeypox. This research gap encouraged us to develop new molecule fight monkeypox smallpox disease. So, firstly, fifty different curcumin derivatives were collected from natural sources, PubChem database, determine capabilities Monkeypox Smallpox. Material method Preliminarily, molecular docking experiment conducted, majority substances produced expected binding affinities. Then, twelve picked up further analysis based on maximum score. After that, density functional theory (DFT) was used chemical characterizations highest occupied orbital (HOMO), lowest unoccupied (LUMO), softness, hardness, etc. Results The mentioned demonstrated scores greater than 6.80 kcal/mol, significant affinity at -8.90 though 12 molecules had higher (-8.00 kcal/mol -8.9 kcal/mol), better standard medications. dynamic simulation described by root mean square deviation (RMSD) root-mean-square fluctuation (RMSF), demonstrating all compounds might be stable physiological system. Conclusion conclusion, each derivative has outstanding absorption, distribution, metabolism, excretion, toxicity (ADMET) characteristics. Hence, we recommended aforementioned potential agents Smallpox virus, more vivo investigations warranted substantiate our findings.

Язык: Английский

---

Mechanistic inhibition of Monkeypox and Marburg virus infection by O-rhamnosides and Kaempferol-o-rhamnosides derivatives: a new-fangled computational approach

Frontiers in Cellular and Infection Microbiology, Год журнала: 2023, Номер 13

Опубликована: Май 24, 2023

The increasing incidence of Monkeypox virus (Mpox) and Marburg (MARV) infections worldwide presents a significant challenge to global health, as limited treatment options are currently available. This study investigates the potential several O-rhamnosides Kaempferol-O-rhamnosides Mpox MARV inhibitors using molecular modeling methods, including ADMET, docking, dynamics/MD simulation. effectiveness these compounds against viruses was assessed Prediction Activity Spectra for Substances (PASS) prediction. study’s primary focus is docking prediction, which demonstrated that ligands (L07, L08, L09) bind (PDB ID: 4QWO) 4OR8) with binding affinities ranging from -8.00 kcal/mol -9.5 kcal/mol. HOMO-LUMO based quantum calculations were employed determine gap frontier orbitals (FMOs) estimate chemical potential, electronegativity, hardness, softness. Drug similarity ADMET prediction assessments pharmacokinetic properties revealed likely non-carcinogenic, non-hepatotoxic, rapidly soluble. Molecular dynamic (MD) used identify most favorable docked complexes involving bioactive chemicals. MD simulations indicate varying types kaempferol-O-rhamnoside necessary successful validation maintaining stability complex. These findings could facilitate discovery novel therapeutic agents treating illnesses caused by viruses.

Язык: Английский

---

Health-related quality of life after prosthodontic rehabilitation in patients with COVID-19-associated mucormycosis: A systematic review

The Journal of Indian Prosthodontic Society, Год журнала: 2025, Номер 25(1), С. 30 - 39

Опубликована: Янв. 1, 2025

Health-related quality of life (HRQOL) measures an individual’s ability to function optimally in various aspects and their subjective sense well-being across the physical, mental, social dimensions health. COVID-19-associated mucormycosis often necessitates aggressive surgical removal infected tissues restoration defect. Evaluating patient satisfaction HRQOL following prosthodontic rehabilitation is essential for assessing effectiveness interventions on individuals dealing with condition. This systematic review aimed evaluate impact affected by mucormycosis. The research strictly adhered Preferred Reporting Items Systematic Reviews Meta-Analyses guidelines was registered International Prospective Register (PROSPERO 2023CRD42023495778). Comprehensive searches databases such as PubMed, Cochrane Library, Google Scholar, Semantic Scholar were done include studies after year 2020, written English language, regardless geographic location, which presented data Independently, three authors conducted a comprehensive assessment selected using National Heart Lung Blood Institute (NHLBI) study tool gauge risk bias specifically before–after (pre–post) lacking control group. A total 116 records screened, out 109 excluded. Eight included study. intervention functional, social, psychological limitations. Questionnaires that Obturator Functioning Scale, Appearance Anxiety Inventory, Patient Health Questionnaire, auditory perception analysis, Oral Impact Profile, Liverpool Rehabilitation Questionnaire. reported compositely 2 8 studies. There improvement all patients shows rehabilitation. Obturators zygomatic implant-supported prostheses are preferred options who have undergone maxillectomy due Prosthodontic has positive improving well-being.

Язык: Английский

---

Society Strategies in Infectious Diseases

Опубликована: Янв. 20, 2025

Язык: Английский

---

Post-COVID-19-Associated Mucormycosis: An Observational Study with Clinical and Radiographical Presentation

Advances in Human Biology, Год журнала: 2025, Номер unknown

Опубликована: Май 3, 2025

Abstract Introduction: Mucormycosis is an emerging fungal infection increasingly affecting COVID-19 patients, especially those with diabetes. Rhizopus oryzae thrives in high-iron conditions, causing angioinvasion and tissue necrosis. As reported 31%–50% of cases during COVID-19’s second wave, early diagnosis management are crucial to prevent severe complications fatalities. Materials Methods: We conducted a multicentre retrospective study analyse the clinicoepidemiological profile mucormycosis non-COVID-19 patients. Amongst 492 screened cases, 47 confirmed patients were included. Data collection focused on demographics, clinical features, comorbidities, risk factors, treatments diagnostic findings. Results: COVID-19-associated (CAM) them, 25 had history symptoms, while 15 showed no significant history. The aimed provide data CAM acute recent cases. Conclusion: rapidly spreading disease prolonged corticosteroids or This highlights radiographic emphasising diagnosis. A larger recommended.

Язык: Английский

---

Exploring the therapeutic potential of Thymus vulgaris ethanol extract: a computational screening for antimicrobial compounds against COVID-19 induced mucormycosis

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Май 7, 2025

Язык: Английский

---

Impact of Mucormycosis on Health of Covid Patients: A Review

ES Food & Agroforestry, Год журнала: 2023, Номер unknown

Опубликована: Янв. 1, 2023

Mucormycosis is a life threatening fungal and mold infection belongs to order from class zygomycetes.It mainly affects people who have health problems or take medicines that lower the body's ability fight germs sickness.It very rare emerging with high mortality rate has provoked great public concern in context of Covid-19 pandemic.Generally caused by saprophytic mould .The disease often manifests skin also lungs brain.People been unwell COVID-19 are still recovering compromised immune system, which means they're more at risk because their body can't off infection.Mortality rates can approach 100% depending on patient's underlying diseases form mucormycosis.The main causes soil dumping sites building other sources infection.This current review will be focuses impact mucormycosis covid 19 associated patient, as well prevalence, diagnosis treatment.

Язык: Английский

---

Maxillary defects due to COVID-19 associated mucormycosis: Impact on quality of life after rehabilitation with an obturator

Journal of Prosthetic Dentistry, Год журнала: 2023, Номер unknown

Опубликована: Авг. 1, 2023

Язык: Английский

---