Clinical Case Reports, Год журнала: 2024, Номер 12(12)
Опубликована: Дек. 1, 2024
ABSTRACT Post‐COVID‐19 mucormycosis, particularly the rhino‐orbital‐cerebral form, can be life‐threatening. This case highlights importance of maintaining high clinical suspicion, especially in patients with recent COVID‐19 history. Prompt diagnosis, aggressive surgical debridement, and antifungal therapy are crucial for successful management, even without traditional risk factors.
Язык: Английский
Journal of Prosthetic Dentistry, Год журнала: 2023, Номер unknown
Опубликована: Авг. 1, 2023
Язык: Английский
Процитировано
5
IntechOpen eBooks, Год журнала: 2022, Номер unknown
Опубликована: Ноя. 28, 2022
The cardiovascular system (CVS) is made up of the heart, blood vessels, and blood. fundamental function CVS to transport substances from all parts body. heart major pumping organ, pressurizing for circulation through vessels; propelled away in arteries returns veins. Cardiovascular disease (CVD) an umbrella term a number inter-linked diseases, generally defined as coronary artery disease, cerebrovascular high pressure, peripheral arterial rheumatic congenital arrhythmia, etc. Globally, CVDs are leading cause deaths, according estimation World Health Organization (WHO), about 17.9 million people died 2019, accounting 32% global deaths. About 75% CVD deaths occur low- middle-income countries. This burden can be decreased by careful risk reduction (such lifestyle modification, smoking alcohol cessation, weight optimization, physical exercise), proper medical treatments, including herbal components. prevention reduce occurrence events, thereby reducing premature disability, morbidity, mortality, while prolonging survival quality life.
Язык: Английский
Процитировано
6
International Journal of Surgery, Год журнала: 2023, Номер 109(2), С. 165 - 166
Опубликована: Янв. 18, 2023
Highlights Last couple of years, numerous viral infections are making life-threatening. MVD is a highly life-threatening hemorrhagic fever. Marburg virus categorized under Mononegaviruses within the family Filoviridae. viruses may enter body via fractures or wounds in skin. Dear Editor, Over last and problematic conditions around globe, continuously many people have died. These infectious illnesses include severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)1, Langya henipavirus2, monkeypox3, among others. At same time, another pathogenic epidemic likely to harm global health systems, which cause by disease (MVD). fever that infect humans nonhuman creatures. According findings, it has been linked with high morbidity fatality rates ranging from 24 90% due MVD4. (MARV) was initially recorded 1967 Marburg, Germany, when researchers conducted studies on tissue taken African green monkeys imported Uganda develop polio vaccines. Plasma affected guinea pigs investigated using electron microscopy determine characterize virus, then given name 'Marburg virus.' Multiple simultaneous outbreaks were reported both Yugoslavia Frankfurt. In 1975, South Africa three persons. Human-to-human transmission allowed first infected person transmit his traveling partner nurse Zimbabwe. 1980, third revealed Kenya; man contracted after seeing Kitum Cave, doctor acquired while helping him. 1987, new strain MARV discovered short outbreak Kenya. Nevertheless, 15-year-old Danish kid became 7 days afterward, visiting cave5,6. Filoviridae belongs genus Marburgvirus. The components virion typically cylindrical filamentous. However, rod-shaped, ring-shaped, U-shaped variants occur. diameter 80 nm length 790 but varies greatly. A negative-strand RNA genome ∼19 kbp size protected inside helical nucleocapsid. Glycoprotein one seven structural proteins encoded serves crucial function facilitating entrance into host cells. Virions glycoprotein spikes all over them, extending outward particle surface distance 5–10 nm7,8. MARVs skin, liver, lymph nodes, spleen initial sites infection; swiftly spreads other tissues body. primarily attack cells immune system, particularly monocytes dendritic As result, they inhibit activation system make possible for replicate uncontrollably. Even if does not immediately contaminate lymphocytes, considerable percentages these nonetheless experience apoptosis. This outcome characteristic pathogenesis MVD8,9. Physical interaction contaminated blood, secretions, fluids (via damaged skin mucous membranes) circulation individual another. Objects fabrics (such as clothing bedding) secretions also serve vectors spread MVD. Since found sperm affected, reasonable assume sexual possible. Male sufferers encouraged delay returning activity until at least 12 months, during time should engage safer sex practices. They primary carriers disease10. stages: spread, certain organs recovery phase those late organ/healing phase. humans, incubation 5–9 average be long 21 days. Fever, headache, vomiting, diarrhea, extreme myalgia just some vague symptoms present. typical sign muscle soreness discomfort. It diarrhea lot water, cramps abdomen, vomiting week sickness10,11. Malaria, typhoid, meningitis, fevers share nonspecific symptoms, correct diagnosis more difficult. Diagnosing clinically might difficult times. swabs blood run reverse-transcriptase PCR check If test positive, established. negative effect rule out illness 72 hours observed11,12. Additional methods detecting available, such enzyme-linked immunosorbent antibodies cell culture-based isolation method13. this neither vaccine nor an antiviral medicine approved treatment provision supportive therapy, rehydrating patient either orally intravenously addressing specific enhance likelihood surviving their condition14. Only limited amount research published what now being developed combat MARV. nucleoside analogs, phosphorodiamidite, immunotherapeutic, morpholino oligomers them. would seem favipiravir remdesivir beneficial primates; however, there no evidence suggest acceptable treatments time. established galidesivir effective against period up hours15. Due probability spreading, classified category-4 illness. is, therefore, utmost importance rapidly advance scientific development medications treating Health professionals, legislators, government officials will need collaborate create safety preventive regulations prevent spreading countries. control that's happening right now. Provenance peer review Not commissioned, internally peer-reviewed. Ethical approval applicable. Sources funding None. Authors' contributions S.A.: conceptualization, data curation, writing – original draft preparation, reviewing editing. T.B.E.: editing, visualization, supervision. H.C. K.D.: Conflicts interest disclosure authors declare financial conflict regard content report. Research registration unique identifying number (UIN) Guarantor Talha B. Emran.
Язык: Английский
Процитировано
3
Journal of Prosthetic Dentistry, Год журнала: 2023, Номер unknown
Опубликована: Дек. 1, 2023
Язык: Английский
Процитировано
3
Biomedicine & Pharmacotherapy, Год журнала: 2022, Номер 158, С. 114083 - 114083
Опубликована: Дек. 5, 2022
COronaVIrus Disease 2019 (COVID-19) is a newly emerging infectious disease that spread across the world, caused by novel coronavirus Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2).Despite advancements in science led to creation of vaccine, there still an urgent need for new antiviral drugs effective against SARS-CoV-2.This study aimed investigate effect Paulownia tomentosa Steud extract SARS-CoV-2 and evaluate its antioxidant properties, including respiratory smooth muscle relaxant effects.Our results showed P. can inhibit viral replication directly interacting with both 3-chymotrypsin-like protease spike protein.In addition, phyto complex does not reduce lung epithelial cell viability exerts protective action those cells damaged tert-butyl hydroperoxide , toxic agent able alter cells' functions via increased oxidative stress.These data suggest potential role COVID-19 treatment, since this act as cytoprotective vitro.
Язык: Английский
Процитировано
5
Antibiotics, Год журнала: 2022, Номер 12(1), С. 31 - 31
Опубликована: Дек. 25, 2022
Mucormycosis is a rare fungal infection, with high mortality, commonly associated diabetes, malignancies, immunosuppressive therapy, and other immunodeficiency conditions. The emergence of mucormycosis cases has been advanced by the COVID-19 pandemic. Clinical presentation variable, from asymptomatic to persistent fever or localized infections. We present case Romanian old man, without diabetes immunodepression, who developed severe rhino-orbital bacterial superinfections, Pseudomonas aeruginosa Klebsiella pneumoniae. late diagnostic antifungal treatment was related extensive lesions, bone tissue loss, required complex reconstruction procedures. review relationships between mucormycosis, COVID-19, suspicion index should be increased in medical practice. COVID-19-Associated-Mucormycosis currently challenging, calling for multidisciplinary collaboration.
Язык: Английский
Процитировано
5
ACS Infectious Diseases, Год журнала: 2024, Номер 10(5), С. 1431 - 1457
Опубликована: Апрель 29, 2024
Mucormycosis, a rare but deadly fungal infection, was an epidemic during the COVID-19 pandemic. The rise in cases (COVID-19-associated mucormycosis, CAM) is attributed to excessive steroid and antibiotic use, poor hospital hygiene, crowded settings. Major contributing factors include diabetes weakened immune systems. main manifesting forms of CAM─cutaneous, pulmonary, deadliest, rhinocerebral─and disseminated infections elevated mortality rates 85%. Recent focus lies on small-molecule inhibitors due their advantages over standard treatments like surgery liposomal amphotericin B (which carry several long-term adverse effects), offering potential central nervous system penetration, diverse targets, simpler dosing owing small size, rendering ability traverse blood–brain barrier via passive diffusion facilitated by phospholipid membrane. Adaptation versatility mucormycosis are multitude virulence factors, enabling pathogen dynamically respond various environmental stressors. A comprehensive understanding these mechanisms imperative for devising effective therapeutic interventions against this highly opportunistic that thrives immunocompromised individuals through its angio-invasive nature. Hence, Review delineates principal it employs persist challenging host environments, current progress developing them.
Язык: Английский
Процитировано
0
International Journal of Science and Research Archive, Год журнала: 2024, Номер 12(2), С. 1232 - 1235
Опубликована: Июль 30, 2024
The filamentous fungus that causes Mucormycosis is a newly discovered angiogenic infection found in large quantities and member of the Zygomycete class's Mucorales order. In patients undergoing hematopoietic allogeneic stem cell transplantation, after candidiasis aspergillosis, mucormycosis has become third most common invasive mycosis. Breathing sporangiospores daily need. remarkably low frequency members nasal mucus indicates airborne contamination either minimal or mucociliary transport removes spores from airway mucus. this review research, new approaches to assessing relationships among host, fungus, antifungal drugs are provided. Aerosols other novel delivery methods might also aid treatment mucormycosis.
Язык: Английский
Процитировано
0
chemistry of plant raw material, Год журнала: 2024, Номер 4, С. 125 - 137
Опубликована: Ноя. 11, 2024
The new coronavirus infection is currently still an important problem for humanity as well the global medical community. COVID-19 virus dangerous because it causes direct damage to epithelium of respiratory tract, thereby contributing penetration bacteria and fungi into tissues body. Invasive mycoses are a serious complication cause high percentage deaths in hospitalized patients. main strains coinfections are: Aspergillus, Mucorales Candida. issue treatment possibility prevention secondary fungal infections particularly acute. aim work was determine antifungal activity poplar (Populus L.) buds propolis with antimicrobial against isolated from patients infection. paper reflects results study investigated samples extracts Populus nigra L. rubrinervis Hort. Alb. (70 96% ethyl alcohol) clinical Aspergillus fumigatus, flavus, niger, Scopulariopsis brevicaulis, Mucor spp. Propolis tincture alcoholic solution reference sample (RS) pinostrobin were comparison preparations. greatest fumigatus (the content active substances alcohol extraction – 0.0022%), flavus (70% 0.0019%), niger brevicaulis 0.0009%). showed lowest fungicidal activity, has A. strains. preparation RS strain. Against tested preparations did not show any pronounced activity. presence postcoid bud presumably associated sum phenolic compounds: flavonoids phenylpropanoids.
Язык: Английский
Процитировано
0
The Egyptian Journal of Otolaryngology, Год журнала: 2023, Номер 39(1)
Опубликована: Июнь 12, 2023
Abstract Background Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) presents with tract-related symptoms such as fever, cough, dyspnea, and chest tightness that could progress rapidly to distress (ARDS). However, disease 2019 (COVID-19) also causes several upper including nasal congestion, sore throat, smell dysfunction. Incidence of mucormycosis in COVID-19 patients was reported during the second wave along other otorhinolaryngology-related complications. Aim This study aimed determine different complications cases a tertiary care center estimation incidence, age, gender distribution, risk factors, treatment, follow-up, mortality status participants. Methodology Patients who recovered from developed long-lasting anosmia, septal abscess, epistaxis, rhino mucormycosis, voice changes were selected for study. After obtaining patient medical records, recorded history, examination, investigations done related associated distribution ENT (Ears, Nose, Throat) collected, this data analyzed. Results The present involved 100 between 18 65 years age which included 78% males 22% females. Of these participants, 92% most common complication, diabetes being factor majority During course study, 10% participants had passed away due Conclusion Early identification highly sensitive post-COVID-19 is essential reduce morbidity among vulnerable populations.
Язык: Английский
Процитировано
1