Comparison of reproductive toxicity between pristine and aged polylactic acid microplastics in Caenorhabditis elegans

Journal of Hazardous Materials, Год журнала: 2024, Номер 466, С. 133545 - 133545

Опубликована: Янв. 17, 2024

Язык: Английский

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Polylactic acid microplastics cause transgenerational reproductive toxicity associated with activation of insulin and hedgehog ligands in C. elegans

The Science of The Total Environment, Год журнала: 2024, Номер 942, С. 173746 - 173746

Опубликована: Июнь 7, 2024

Язык: Английский

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Transgenerational Response of Germline Nuclear Hormone Receptor Genes to Nanoplastics at Predicted Environmental Doses in Caenorhabditis elegans

Toxics, Год журнала: 2024, Номер 12(6), С. 420 - 420

Опубликована: Июнь 7, 2024

Transgenerational nanoplastic toxicity could be detected in Caenorhabditis elegans after exposure at the parental generation (P0-G); however, underlying mechanisms remain largely unclear. We aimed to examine role of germline nuclear hormone receptors (NHRs) controlling transgenerational polystyrene nanoparticles (PS-NPs) based on gene expression screening and functional analysis. Among NHR genes, daf-12, nhr-14, nhr-47 expressions were increased nhr-12 was decreased by PS-NPs (1 10 μg/L). alterations these four genes also induced RNAi caused resistance, whereas conferred susceptibility PS-NP toxicity. After exposure, ins-3, daf-28, ins-39 encoding insulin ligands, efn-3 Ephrin ligand, lin-44 Wnt as well their receptor (daf-2, vab-1, and/or mig-1), dysregulated nhr-47, nhr-12. Therefore, alteration certain NHRs mediate induction affecting secreted ligands offspring exposed organisms.

Язык: Английский

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Diquat Induces Cell Death and dopamine Neuron Loss via Reactive Oxygen Species Generation in Caenorhabditis elegans

Environmental Science & Technology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

Diquat (DQ), a contact herbicide extensively utilized in both agricultural and nonagricultural domains, exhibits high correlation with neuronal disorders. Nevertheless, the toxicity underlying mechanisms associated exposure to environmental concentrations of DQ remain ambiguous. Here, we report dose-dependent cellular neurotoxicity Caenorhabditis elegans. First, significantly compromised development brood size worms, shortened lifespan, caused epidermal abnormalities. An unbiased transcriptomic analysis disclosed several pathways related cell death peroxisome homeostasis this organismal-level toxicity. Moreover, C. elegans led notable increase embryonic death. Concurrently, specifically loss dopamine neurons but not two other types adulthood, which is accordance DQ-induced muscle-related defects such as pharyngeal pumping, body bends, head thrashes. Mechanistically, induces generation reactive oxygen species (ROS) enhances glutathione-related ROS scavenging pathway. Protein levels activities mitochondrial electron transport chain complexes were impaired DQ-treated worms. Collectively, study suggests an ROS-mediated pathway involving behavioral DQ, offers novel mitochondria-related perspective elucidate general by widely distributed herbicide, at near-environment concentrations.

Язык: Английский

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Toxicological assessment & risk evaluation of pesticides and their mixtures through C. elegans & RISK21: a risk-based approach for sustainable agriculture

Journal of Hazardous Materials Letters, Год журнала: 2025, Номер unknown, С. 100145 - 100145

Опубликована: Фев. 1, 2025

Язык: Английский

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Polystyrene nanoplastics at predicted environmental concentrations enhance the toxicity of copper on Caenorhabditis elegans

Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 282, С. 116749 - 116749

Опубликована: Июль 17, 2024

Excessive nanoplastics not only pose a direct threat to the environment but also have propensity adsorb and interact with other pollutants, exacerbating their impact. The coexistence of heavy metals in soils is prevalent phenomenon. However, limited research existed about joint effects two contaminants on soil organisms. In this paper, we ascertained combined toxicity polystyrene (PS-NPs) copper (Cu2+) organisms (Caenorhabditis elegans) at quantities that were present environment, further exploring whether toxicants synergistic or antagonistic. outcomes manifested single exposure low-dose PS-NPs (1 μg/L) would cause significant damage nematodes. After treatment Cu2+, locomotion ability nematode was impaired, accompanied by an elevation reactive oxygen species (ROS) level biphasic response antioxidant enzyme activity. Moreover, Cu2+ induced mRNA up-regulation vit-6, cyp-35a2, hsp-16.2, age-1, cep-1, both which stress-related genes. comparative analysis between groups (with without PS-NPs) revealed group resulted significantly greater toxic nematodes compared alone. Furthermore, addition influenced metabolic profiles Caenorhabditis elegans under stress, numerous differential metabolites associated oxidative defense mechanism. Overall, these findings expected environmental concentration elevated

Язык: Английский

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Chemically engineered CoO -doped flower-like NiO nanoparticles for photodegradation of Bisphenol A and Orange II Dye, and genetic screening of toxicity via Caenorhaditis elegans

Journal of environmental chemical engineering, Год журнала: 2024, Номер 12(5), С. 113677 - 113677

Опубликована: Июль 31, 2024

Язык: Английский

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6-PPD quinone causes lipid accumulation across multiple generations differentially affected by metabolic sensors and components of COMPASS complex in Caenorhabditis elegans

Environmental Pollution, Год журнала: 2024, Номер 366, С. 125539 - 125539

Опубликована: Дек. 15, 2024

Язык: Английский

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Alkaloids extracted from Dendrobium officinale grown in diverse environments exhibited robust antioxidative and antiaging activity

Journal of Future Foods, Год журнала: 2025, Номер 5(6), С. 591 - 604

Опубликована: Янв. 29, 2025

Язык: Английский

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Influence of soil properties and residence time on the toxicity of exogenous arsenic to soil-dwelling Caenorhabditis elegans

Journal of Soils and Sediments, Год журнала: 2025, Номер unknown

Опубликована: Фев. 15, 2025

Язык: Английский

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