Antimicrobial activity of Monascus purpureus-derived red pigments against Salmonella typhimurium, Escherichia coli, and Enterococcus faecalis
AMB Express,
Год журнала:
2025,
Номер
15(1)
Опубликована: Янв. 4, 2025
Abstract
The
rise
of
antimicrobial-resistant
microorganisms
(AMR)
poses
a
significant
global
challenge
to
human
health
and
economic
stability.
In
response,
various
scientific
communities
are
seeking
safe
alternatives
antibiotics.
This
study
comprehensively
investigates
the
antibacterial
effects
red
dye
derived
from
Monascus
purpureus
against
three
bacterial
pathogens:
Salmonella
typhimurium
ATCC14028,
Escherichia
coli
ATCC8739,
Enterococcus
faecalis
ATCC25923.
was
extracted
ATCC16436
strain,
using
1
mg
in
ml
DMSO
achieve
concentration
1000
µg/ml.
chemical
profile
extract
analyzed
GC–MS
analysis,
confirming
presence
several
bioactive
antimicrobial
compounds,
including
aspidospermidin-17-ol,
1-acetyl-16-methoxy,
octanoic
acid,
hexadecanoic
acid
methyl
ester.
tested
strains
at
varying
concentrations
determine
minimum
inhibitory
(MIC)
bactericidal
(MBC).
results
demonstrated
activity,
with
highest
MIC
MBC
values
6.25/12.5
µg/ml
S.
.
activity
compared
five
conventional
antibiotics
disc
diffusion
method,
revealing
superior
effectiveness,
particularly
,
an
inhibition
zone
measuring
20
±
0.22
mm.
Scanning
electron
microscopy
employed
explore
mechanism
action
extract,
highlighting
its
impact
on
plasma
membrane
permeability
interference
cellular
energy
production.
These
findings
suggest
that
-derived
represents
promising
natural
alternative
antibiotics,
demonstrating
potent
potential
as
novel
therapeutic
agent
combating
resistance.
Язык: Английский
The Tolerance Differences of Two Industrial Hemp Varieties Under Lead (Pb) Stress
Toxics,
Год журнала:
2025,
Номер
13(2), С. 90 - 90
Опубликована: Янв. 24, 2025
Industrial
hemp
is
a
crop
with
high
tolerance
and
accumulation
of
lead
(Pb).
Improving
the
Pb
capacity
industrial
great
scientific
practical
importance.
This
study
utilized
pot
soil
contaminated
to
investigate
differences
in
between
two
varieties,
Yunma1
(YM)
Shaanxi
Hemp
(SM),
under
stress.
The
results
indicated
that
mainly
accumulates
roots
YM
SM
(70–80%),
having
higher
than
SM.
It
worth
nothing
concentration
conditions
(5000
mg/kg),
twice
Accumulation
characteristics
different
plant
tissues
followed
pattern:
>
stems
leaves
fibers
seeds.
In
YM,
approximately
70%
absorbed
was
fixed
30%
transported
above-ground
parts.
contrast,
more
50%
by
areas,
causing
some
degree
damage
leaves.
Even
when
concentrations
exceed
4000
mg/kg,
exhibits
strong
(tolerance
index
greater
90%),
normal
growth
no
signs
toxicity.
However,
showed
level
<
at
concentrations,
significant
heavy
metal
toxicity
symptoms
areas.
These
provide
important
information
for
remediation
soils
mining
Язык: Английский