Neurological sequelae of long COVID: a comprehensive review of diagnostic imaging, underlying mechanisms, and potential therapeutics
Frontiers in Neurology,
Год журнала:
2025,
Номер
15
Опубликована: Фев. 7, 2025
One
lingering
effect
of
the
COVID-19
pandemic
created
by
SARS-CoV-2
is
emergence
Long
COVID
(LC),
characterized
enduring
neurological
sequelae
affecting
a
significant
portion
survivors.
This
review
provides
thorough
analysis
these
disruptions
with
respect
to
cognitive
dysfunction,
which
broadly
manifest
as
chronic
insomnia,
fatigue,
mood
dysregulation,
and
impairments
dysfunction.
Furthermore,
we
characterize
how
diagnostic
tools
such
PET,
MRI,
EEG,
ultrasonography
provide
critical
insight
into
subtle
anomalies
that
may
mechanistically
explain
disease
phenotype.
In
this
review,
explore
mechanistic
hypotheses
changes,
describe
CNS
invasion,
neuroinflammation,
blood-brain
barrier
disruption,
gut-brain
axis
along
novel
vascular
disruption
hypothesis
highlights
endothelial
dysfunction
hypoperfusion
core
underlying
mechanism.
We
lastly
evaluate
clinical
treatment
landscape,
scrutinizing
efficacy
various
therapeutic
strategies
ranging
from
antivirals
anti-inflammatory
agents
in
mitigating
multifaceted
symptoms
LC.
Язык: Английский
Proposing Bromo-Epi-Androsterone for Neurologic Long-COVID
Опубликована: Июль 1, 2024
The
neurologic
effects
of
long-COVID
are
a
therapeutic
challenge.
This
article
discusses
the
immunologic
manifestations
and
proposes
non-androgenic,
synthetic
analog
dehydroepiandrosterone
(DHEA),
bromo-epi-androsterone
(BEA),
as
candidate
for
clinical
trials
this
exigent
collection
conditions.
Moreover,
because
there
is
an
association
between
Alzheimer’s
disease,
evaluation
BEA
in
may
serve
proxy
its
effect
on
neuroinflammatory
biomarkers
disease
that
shared
with
long-COVID.
Язык: Английский
Trends in Global Burden of Alzheimer’s Disease and Other Dementias Attributable to High Fasting Plasma Glucose, 1990–2021
Medicina,
Год журнала:
2024,
Номер
60(11), С. 1783 - 1783
Опубликована: Окт. 31, 2024
:
Alzheimer's
disease
and
other
dementias
represent
some
of
the
leading
public
health
concerns
worldwide.
This
study
aimed
to
assess
global
burden
attributable
high
fasting
plasma
glucose
in
last
decades.
Язык: Английский
Comparing COVID-19 vaccination coverage, adverse reactions and impact of social determinants of health on vaccine hesitancy in ADRD/MCI and non-ADRD/MCI population: protocol for a retrospective cross-sectional study
BMJ Open,
Год журнала:
2024,
Номер
14(7), С. e082988 - e082988
Опубликована: Июль 1, 2024
COVID-19
vaccination
is
crucial
for
vulnerable
people
with
underlying
chronic
conditions
such
as
Alzheimer's
disease
and
related
dementias
(ADRD)
mild
cognitive
impairment
(MCI).
These
individuals
face
unique
challenges,
including
higher
risk
of
COVID-19,
difficulties
in
adopting
preventive
behaviours
vaccine
hesitancy
due
to
concerns
about
adverse
reactions.
Therefore,
efforts
promote
vaccination,
boosters
tailored
the
currently
circulating
virus,
are
essential
ADRD/MCI.
Язык: Английский
Infection, Neuroinflammation and Interventions for Healthy Brain and Longevity
Healthy ageing and longevity,
Год журнала:
2024,
Номер
unknown, С. 255 - 275
Опубликована: Янв. 1, 2024
Язык: Английский
Anti-Inflammatory and Neuroprotective Polyphenols Derived from the European Olive Tree, Olea europaea L., in Long COVID and Other Conditions Involving Cognitive Impairment
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(20), С. 11040 - 11040
Опубликована: Окт. 14, 2024
The
European
olive
tree,
Olea
europaea
L.,
and
its
polyphenols
hold
great
therapeutic
potential
to
treat
neuroinflammation
cognitive
impairment.
This
review
examines
the
evidence
for
anti-inflammatory
neuroprotective
actions
of
their
in
treatment
long
COVID
neurodegenerative
diseases
such
as
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
multiple
sclerosis
(MS).
Key
findings
suggest
that
exhibit
antioxidant,
anti-inflammatory,
neuroprotective,
antiviral
properties,
making
them
promising
candidates
intervention,
especially
when
formulated
unique
combinations.
Recommendations
future
research
directions
include
elucidating
molecular
pathways
through
mechanistic
studies,
exploring
implications
polyphenol
supplementation,
conducting
clinical
trials
assess
efficacy
safety.
Investigating
synergistic
effects
with
other
agents
addressing
different
targets
is
suggested
further
exploration.
reviewed
strengthens
translational
value
conditions
involving
dysfunction
emphasizes
novelty
new
formulations.
Язык: Английский
Perspective Chapter: Exploring Cognitive Impairment in Long COVID – Insights and Therapeutic Progress
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 4, 2024
Coronavirus
disease
2019
(COVID-19)
was
caused
by
a
novel
severe
acute
respiratory
syndrome
related
coronavirus
(SARS-CoV-2)
that
occurred
in
late
and
soon
emerged
as
global
pandemic.
Even
after
recovering
from
the
initial
infection,
approximately
45%
of
patients
experience
persistent
symptoms,
known
post-COVID
syndromes
or
long
COVID,
which
can
endure
for
weeks
to
months.
Among
prominent
lingering
symptoms
are
fatigue,
cognitive
impairment
(commonly
referred
brain
fog),
musculoskeletal
disorders.
Brain
fog
manifests
confusion,
difficulty
focusing,
memory
loss.
Although
exact
cause
deficits
induced
SARS-CoV-2
remains
unclear,
it
is
speculated
chronic
inflammation
resulting
residual
virus
remnants
body’s
reservoirs
stress-released
peptides
may
play
significant
role.
This
chapter
aims
delve
into
etiology
recent
advancements
treating
associated
with
COVID-19,
shedding
light
on
our
understanding
this
complex
phenomenon
potential
therapeutic
strategies.
Язык: Английский