Neuroprotective signaling by hydrogen sulfide and its dysregulation in Alzheimer's disease
Current Opinion in Chemical Biology,
Год журнала:
2024,
Номер
82, С. 102511 - 102511
Опубликована: Авг. 13, 2024
The
ancient
messenger
molecule
hydrogen
sulfide
(H
Язык: Английский
Role of cystathionine-β-synthase and hydrogen sulfide in down syndrome
Neurotherapeutics,
Год журнала:
2025,
Номер
unknown, С. e00584 - e00584
Опубликована: Апрель 1, 2025
Язык: Английский
Intracellular hydrogen sulfide induces stress granule formation and translational repression through eIF2α phosphorylation
Archives of Toxicology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 9, 2025
Язык: Английский
Increased hydrogen sulfide turnover serves a cytoprotective role during the development of replicative senescence
Biochemical Pharmacology,
Год журнала:
2024,
Номер
unknown, С. 116595 - 116595
Опубликована: Окт. 1, 2024
Язык: Английский
Recent advances in the role of hydrogen sulfide in age-related diseases
Experimental Cell Research,
Год журнала:
2024,
Номер
441(2), С. 114172 - 114172
Опубликована: Июль 23, 2024
Язык: Английский
Emerging roles of hydrogen sulfide-metabolizing enzymes in cancer
Redox Report,
Год журнала:
2024,
Номер
29(1)
Опубликована: Дек. 6, 2024
Gasotransmitters
play
crucial
roles
in
regulating
many
physiological
processes,
including
cell
signaling,
cellular
proliferation,
angiogenesis,
mitochondrial
function,
antioxidant
production,
nervous
system
functions
and
immune
responses.
Hydrogen
sulfide
(H2S)
is
the
most
recently
identified
gasotransmitter,
which
characterized
by
its
biphasic
behavior.
At
low
concentrations,
H2S
promotes
bioenergetics,
whereas
at
high
it
can
exert
cytotoxic
effects.
Cystathionine
β-synthetase
(CBS),
cystathionine-γ-lyase
(CSE),
3-mercaptopyruvate
sulfurtransferase
(3-MST),
cysteinyl-tRNA
synthetase
2
(CARS2)
are
pivotal
players
biosynthesis
mammalian
cells
tissues.
The
focus
of
this
review
regulation
various
pathways
involved
metabolism
forms
cancer.
Key
enzymes
process
include
oxidation
unit
(SOU),
includes
sulfide:quinone
oxidoreductase
(SQOR),
human
ethylmalonic
encephalopathy
protein
1
(hETHE1),
rhodanese,
sulfite
oxidase
(SUOX/SO),
cytochrome
c
(CcO)
enzymes.
Furthermore,
potential
role
methylation
processes
mediated
thiol
S-methyltransferase
(TMT)
thioether
(TEMT)
outlined
cancer
biology,
with
opportunities
for
targeting
them
clinical
translation.
In
order
to
understand
oncogenesis
tumor
progression,
one
must
appreciate
intricate
interplay
between
H2S-synthesizing
H2S-catabolizing
Язык: Английский
Autophagy is a promising process for linking inflammation and redox homeostasis in Down syndrome
Frontiers in Pharmacology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 2, 2024
Trisomy
21,
characterized
by
the
presence
of
an
additional
chromosome
leads
to
a
set
clinical
features
commonly
referred
as
Down
syndrome
(DS).
The
pathological
phenotypes
observed
in
DS
are
caused
combination
factors,
such
mitochondrial
dysfunction,
neuroinflammation,
oxidative
stress,
disrupted
metabolic
patterns,
and
changes
protein
homeostasis
signal
transduction,
these
factors
collectively
induce
neurological
alterations.
In
DS,
triplication
21
micronuclei
arising
from
missegregation
chromosomes
closely
associated
with
inflammation
development
redox
imbalance.
Autophagy,
essential
biological
process
that
affects
cellular
homeostasis,
is
powerful
tool
facilitate
degradation
redundant
or
dysfunctional
cytoplasmic
components,
thereby
enabling
recycling
their
constituents.
Targeting
autophagy
has
been
suggested
promising
method
balance
intracellular
stress
improve
dysfunction.
this
review,
we
summarize
role
regulating
discuss
crosslinks.
A
comprehensive
elucidation
roles
offers
novel
insights
for
therapeutic
strategies
aimed
at
aneuploidy-associated
diseases.
Язык: Английский
Harshly Oxidized Activated Charcoal Enhances Protein Persulfidation with Implications for Neurodegeneration as Exemplified by Friedreich’s Ataxia
Nanomaterials,
Год журнала:
2024,
Номер
14(24), С. 2007 - 2007
Опубликована: Дек. 13, 2024
Harsh
acid
oxidation
of
activated
charcoal
transforms
an
insoluble
carbon-rich
source
into
water-soluble,
disc
structures
graphene
decorated
with
multiple
oxygen-containing
functionalities.
We
term
these
pleiotropic
nano-enzymes
as
“pleozymes”.
A
broad
redox
potential
spans
many
crucial
reactions
including
the
hydrogen
sulfide
(H2S)
to
polysulfides
and
thiosulfate,
dismutation
superoxide
radical
(O2−*),
NADH
NAD+.
The
H2S
is
predicted
enhance
protein
persulfidation—the
attachment
sulfur
cysteine
residues.
Persulfidated
proteins
act
intermediates,
persulfidation
protects
from
irreversible
ubiquitination,
providing
important
means
signaling.
Protein
believed
decline
in
several
neurological
disorders
aging.
Importantly,
consistent
role
signaling,
master
antioxidant
transcription
factor
Nrf2
regulated
by
Keap1’s
persulfidation.
Here,
we
demonstrate
that
pleozymes
increased
overall
cells
apparently
healthy
individuals
mitochondrial
mutation
responsible
for
Friedreich’s
ataxia.
further
find
specifically
enhanced
Keap1
persulfidation,
subsequent
accumulation
Nrf2’s
targets.
Язык: Английский