Global, regional, and national burden of neuroblastoma and peripheral nervous system tumours in individuals aged over 60 from 1990 to 2021: a trend analysis of global burden of disease study

Journal of Health Population and Nutrition, Год журнала: 2025, Номер 44(1)

Опубликована: Март 17, 2025

Abstract Purpose Elderly individuals diagnosed with neuroblastoma and peripheral nervous system tumours often have a poor prognosis. However, there is currently lack of comprehensive analysis on these conditions in older adults. This study aims to determine the global epidemiological trends (in aged 60 above). Methods We obtained cross-sectional data from 2021 Global Burden Disease, Injuries, Risk Factors Study (GBD) ( https://vizhub.healthdata.org/gbd-results/ ). assessed burden elderly 1990 using indicators such as prevalence incidence. These were classified by global, national, regional levels, further stratified Socio-Demographic Index (SDI), age, gender. The results are organized SDI, gender categories. Results From 2021, age-standardised incidence rates among increased 0.06 (95% UI 0.05, 0.08) 0.12 0.09, 0.15) per 100,000 0.11 0.13) 0.22 0.17, 0.26) 100,000, respectively. Age-standardised mortality DALY also rose. Central Europe had highest while Eastern rate. East Asia reported number total cases experienced fastest growth, significant increases prevalence, incidence, mortality, rates. Gender disparities evident, men showing higher than women, greater EAPC values indicating increase disease over time. age-specific found 90–94 age group, 70–74 group burden. Conclusion continuous rise highlights pressing necessity for focused public health measures improved treatment approaches. Addressing regional, gender, age-related requires approach that integrates medical advancements, social support, policies. Future research should explore potential risk factors innovative therapies mitigate this growing challenge.

Язык: Английский

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Effects of Different Training Intensity Distributions on Endurance Capacity in Breast and Prostate Cancer Survivors: A Randomized Controlled Trial

European Journal of Sport Science, Год журнала: 2025, Номер 25(5)

Опубликована: Апрель 8, 2025

ABSTRACT This study aimed to compare the effects of isocaloric polarized and threshold training intensity distribution on endurance capacity in breast prostate cancer survivors. A total 28 27 survivors were randomly assigned a (POL, n = (13 women), age 60 ± 8 years, peak oxygen uptake (VO 2peak ) 23 mL·min −1 kg ), or group (ThT, (15 59 10 VO who completed two sessions per week cycle ergometer over 12 weeks. Exercise duration was adapted obtain equivalent energy expenditure both groups. Cardiopulmonary exercise verification tests performed determine , power output (PPO), ventilatory (VT 1 blood lactate thresholds (LT IAT)), maximal exhaustion. POL did not achieve planned rather pyramidal training. Pyramidal significantly ( p < 0.001) improved regarding (0.09 0.12 L·min PPO (27 17W), at VT (11 13W), 0.11 LT (7 12W), IAT (12 14W). No difference found between groups, but ThT required less time than described improvements (59 min/week vs. 76 11 min/week). Comparison distributions revealed no significant differences groups (Pyramidal: 170 43 kJ/session, ThT: 175 35 0.10). resulted comparable survivors, with requiring for these effects.

Язык: Английский

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Exercise and survival benefit in cancer patients: evidence from a comprehensive meta-analysis

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Апрель 12, 2025

Язык: Английский

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Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications

Nutrients, Год журнала: 2025, Номер 17(8), С. 1351 - 1351

Опубликована: Апрель 15, 2025

Vitamin D plays a crucial role in the regulation of immune system, with immunomodulatory effects that are key prevention colorectal cancer (CRC). Over past decades, research has shown this steroid hormone impacts much more than bone health, significantly influencing responses. enhances organ functions such as spleen and lymph nodes, boosts T-cell activity, which is essential defending body against tumors. Additionally, vitamin mitigates inflammatory responses closely linked to development, reducing inflammation contributes CRC. It acts via receptors (VDRs) expressed on cells, modulating Adequate levels influence gene expression related cell proliferation, inhibiting tumor development. also activates mechanisms suppress survival, migration, metastasis. Low have been associated an increased risk CRC, deficiency correlating higher disease incidence. Lifestyle factors, diet high red meat calories but low fiber, fruits, vegetables, well physical inactivity, contribute CRC risk. Insufficient calcium intake occurrence poorer clinical outcomes. Maintaining optimal adequate dietary preventing improving patient prognosis. This review explores summarizes findings from randomized trials assessing supplementation

Язык: Английский

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Predicting Heart Rate at the Anaerobic Threshold Using a Machine Learning Model Based on a Large-Scale Population Dataset

Journal of Clinical Medicine, Год журнала: 2024, Номер 14(1), С. 21 - 21

Опубликована: Дек. 24, 2024

Background/Objectives: For effective exercise prescription for patients with cardiovascular disease, it is important to determine the target heart rate at level of anaerobic threshold (AT-HR). The AT-HR mainly determined by cardiopulmonary testing (CPET). aim this study develop a machine learning (ML) model predict solely from non-exercise clinical features. Methods: From consecutive 21,482 cases CPET between 2 February 2008 and 1 December 2021, an appropriate subset was selected train our ML model. Data consisted 78 features, including age, sex, anthropometry, diagnosis, risk factors, vital signs, blood tests, echocardiography. We predicted using method called gradient boosting, along rank each feature in terms its contribution prediction. accuracy evaluated comparing HRs guideline-recommended equations mean absolute error (MAE). Results: A total 8228 participants included healthy individuals disease were 62 ± 15 years age (69% male). MAE ML-based 7.7 0.2 bpm, which significantly smaller than those equations; results Karvonen formulas coefficients 0.7 0.4 34.5 0.3 bpm 11.9 respectively, simpler formulas, rest HR + 10 +20 15.9 9.7 respectively. ranking revealed that features make significant prediction include resting rate, N-terminal pro-brain natriuretic peptide (NT-proBNP), systolic pressure, highly sensitive C-reactive protein (hsCRP), β-blockers, order. Prediction top 20 comparable all Conclusions: An accurate proposed. expect will facilitate performing cardiac rehabilitation. selection technique newly unveiled some major determinants AT-HR, such as NT-proBNP hsCRP.

Язык: Английский

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The Interplay Between Type 2 Diabetes, Cardiorespiratory Fitness and Sudden Cardiac Death: A Prospective Cohort Study

CJC Open, Год журнала: 2024, Номер 6(11), С. 1403 - 1410

Опубликована: Авг. 23, 2024

To evaluate the individual and joint effects of type 2 diabetes (T2D) status cardiorespiratory fitness (CRF) level with sudden cardiac death (SCD) risk.

Язык: Английский

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