Novel biomarkers of mitochondrial dysfunction in Long COVID patients DOI Creative Commons
Titanilla Szögi, Barbara N. Borsos,

Dejana Masic

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Coronavirus disease 2019 (COVID-19) can lead to severe acute respiratory syndrome, and while most individuals recover within weeks, approximately 30–40% experience persistent symptoms collectively known as Long COVID, post-COVID-19 or post-acute sequelae of syndrome coronavirus 2 (SARS-CoV-2) infection (PASC). These enduring symptoms, including fatigue, difficulties, body pain, short-term memory loss, concentration issues, sleep disturbances, persist for months. According recent studies, SARS-CoV-2 causes prolonged disruptions in mitochondrial function, significantly altering cellular energy metabolism. Our research employed transmission electron microscopy reveal distinct structural abnormalities COVID patients, notably significant swelling, disrupted cristae, an overall irregular morphology, which indicates distress. We noted increased levels superoxide dismutase 1 signals oxidative stress elevated autophagy-related 4B cysteine peptidase levels, indicating mitophagy. Importantly, our analysis also identified reduced circulating cell-free DNA (ccf-mtDNA) these serving a novel biomarker the condition. findings underscore crucial role dysfunction pathogenesis COVID. Further exploration molecular mechanisms underlying post-viral is critical, particularly understand roles autoimmune reactions reactivation latent viruses perpetuating conditions. This comprehensive understanding could pave way targeted therapeutic interventions designed alleviate chronic impacts By utilizing ccf-mtDNA other biomarkers, we enhance diagnostic capabilities improve management this complex syndrome.

Язык: Английский

Long COVID: a clinical update DOI
Trisha Greenhalgh, Manoj Sivan,

Alice Perlowski

и другие.

The Lancet, Год журнала: 2024, Номер 404(10453), С. 707 - 724

Опубликована: Июль 31, 2024

Язык: Английский

Процитировано

78
Sex-specific mechanisms in vascular aging: exploring cellular and molecular pathways in the pathogenesis of age-related cardiovascular and cerebrovascular diseases DOI Creative Commons
Anna Ungvari, Rafał Gulej, Roland Patai

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Язык: Английский

Процитировано

3
Cerebromicrovascular mechanisms contributing to long COVID: implications for neurocognitive health DOI Creative Commons
Mónika Fekete, Andrea Ceglédi,

Ágnes Szappanos

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Янв. 7, 2025

Abstract Long COVID (also known as post-acute sequelae of SARS-CoV-2 infection [PASC] or post-COVID syndrome) is characterized by persistent symptoms that extend beyond the acute phase infection, affecting approximately 10% to over 30% those infected. It presents a significant clinical challenge, notably due pronounced neurocognitive such brain fog. The mechanisms underlying these effects are multifactorial, with mounting evidence pointing central role cerebromicrovascular dysfunction. This review investigates key pathophysiological contributing cerebrovascular dysfunction in long and their impacts on health. We discuss how endothelial tropism direct vascular trigger dysfunction, impaired neurovascular coupling, blood–brain barrier disruption, resulting compromised cerebral perfusion. Furthermore, appears induce mitochondrial enhancing oxidative stress inflammation within cells. Autoantibody formation following also potentially exacerbates injury, chronic ongoing compromise. These factors collectively contribute emergence white matter hyperintensities, promote amyloid pathology, may accelerate neurodegenerative processes, including Alzheimer’s disease. emphasizes critical advanced imaging techniques assessing health need for targeted interventions address complications. A deeper understanding essential advance treatments mitigate its long-term consequences.

Язык: Английский

Процитировано

2
Neurologic Manifestations of Long COVID Disproportionately Affect Young and Middle‐Age Adults DOI Creative Commons
Natasha A. Choudhury,

Shreya Mukherjee,

Tracey Singer

и другие.

Annals of Neurology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 22, 2024

Objective To investigate neurologic manifestations of post‐acute sequelae SARS‐CoV‐2 infection (Neuro‐PASC) in post‐hospitalization Neuro‐PASC (PNP) and non‐hospitalized (NNP) patients across the adult lifespan. Methods Cross‐sectional study first consecutive 200 PNP 1,100 NNP evaluated at a Neuro‐coronavirus disease 2019 (COVID‐19) clinic between May 2020 March 2023. Patients were divided into younger (18–44 years), middle‐age (45–64 older (65+ years) age groups. Results Younger individuals accounted for 142 (71%) 995 1100 (90.5%) patients. Significant age‐related differences frequencies comorbidities abnormal findings demonstrated higher prevalence Conversely, 10 months from COVID‐19 onset, we found significant symptoms indicating lower prevalence, therefore, symptom burden, individuals. Moreover, there subjective impression fatigue (median [interquartile range (IQR)] patient‐reported outcomes measurement information system [PROMIS] score: 64 [57–69], 63 [57–68], 60.5 [50.8–68.3]; p = 0.04) sleep disturbance [IQR] PROMIS 57 [51–63], 56 [53–63], 54 [46.8–58]; 0.002) group, commensurate with impairment quality life (QoL) among Finally, objective executive function National Institutes Health [NIH] toolbox 48 [35–63], 49 [38–63], 54.5 [45–66.3]; 0.01), working memory NIH 47 [40–53], 50 [44–57], [43–58]; 0.0002) patients, worst performance coming group. Interpretation are disproportionally affected by regardless acute severity. Although people more frequently have comorbidities, suffer burden cognitive dysfunction contributing to decreased QoL. principally affects adults their prime, profound public health socioeconomic impacts warranting dedicated resources prevention, diagnosis interventions. ANN NEUROL 2024

Язык: Английский

Процитировано

7
Insights from antiaging-related X discussions: A six-year #Longevity hashtag analysis study DOI Creative Commons

Joanna Bensz,

Dariusz Sołdacki,

Ziyi Ma

и другие.

Current Research in Biotechnology, Год журнала: 2025, Номер 9, С. 100280 - 100280

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

0
Impact of Severe COVID-19 on Accelerating Dementia Onset: Clinical and Epidemiological Insights DOI Creative Commons

Sasha Mukhija,

Max Sunog,

Colin Magdamo

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Март 27, 2025

Severe COVID-19 infection has been associated with neurological complications, but its role in accelerating cognitive decline remains unclear. To determine whether individuals hospitalized for severe exhibit a higher incidence of new onset impairment compared to those other conditions. A retrospective study emulating target trial using Mass General Brigham electronic health records (March 2020-August 2024). The causal effect hospitalization was estimated via cumulative functions accounting the competing risk death. Multicenter hospital-based across healthcare system. total 221613 patients met eligibility criteria, including 6454 (2.0%) admitted due and 215159 (98.0%) all Patients were excluded if they had less than three months follow-up (due censoring, impairment, or death), younger 55 years at baseline, no prior visit year before baseline. primary outcome new-onset identified ICD codes dementia medication prescriptions. analysis hazard ratio relative hospitalizations, along difference 4.5 functions. Inverse propensity score weighting used balance covariates (age, sex, comorbidities, period). Among eligible (mean [SD] age, 69.55 [9.42] years, 55% female), significantly older more comorbidities (p < 0.05). developing (Hazard Ratio: 1.14 [95% CI: 1.02-1.30], P = 0.018). At 12.5% 11.3-13.5] group, 11.6% 11.1-12.1] non-COVID-19 group. an elevated clinically recognized impairment. Future studies are needed validate findings care settings. Early screening intervention may help optimize long-term outcomes patients. Question: Do have conditions?Findings: In this patients, COVID-19, observed among patients.Meaning: recognition diagnosis crucial optimizing patient outcomes.

Язык: Английский

Процитировано

0
The role of atrial fibrillation in vascular cognitive impairment and dementia: epidemiology, pathophysiology, and preventive strategies DOI Creative Commons
Mónika Fekete, Eric M. Liotta, Tihamér Molnár

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Авг. 13, 2024

The aging population in Europe faces a substantial burden from dementia, with vascular cognitive impairment and dementia (VCID) being preventable cause. Atrial fibrillation (AF), common cardiac arrhythmia, increases the risk of VCID through mechanisms such as thromboembolism, cerebral hypoperfusion, inflammation. This review explores epidemiology, pathophysiology, preventive strategies for AF-related VCID. Epidemiological data indicate that AF prevalence rises age, affecting up to 12% individuals over 80. Neuroimaging studies reveal chronic brain changes patients, including strokes, lacunar white matter hyperintensities (WMHs), microbleeds (CMHs), while assessments show impairments memory, executive function, attention. COVID-19 pandemic has exacerbated underdiagnosis AF, leading an increase undiagnosed strokes impairment. Many elderly did not seek medical care due fear exposure, resulting delayed diagnoses. Additionally, reduced family supervision during contributed missed opportunities early detection related complications. Emerging evidence suggests long COVID may also elevate further complicating management this condition. underscores importance comprehensive mitigate decline. Preventive measures, public awareness campaigns, patient education, use smart devices detection, are crucial. Anticoagulation therapy, rate rhythm control, addressing comorbid conditions essential therapeutic strategies. Recognizing cardiovascular impacts especially context pandemic, is advancing health.

Язык: Английский

Процитировано

3
The Role of Trace Elements in COPD: Pathogenetic Mechanisms and Therapeutic Potential of Zinc, Iron, Magnesium, Selenium, Manganese, Copper, and Calcium DOI Open Access
Mónika Fekete,

Andrea Lehoczki,

Tamás Csípő

и другие.

Nutrients, Год журнала: 2024, Номер 16(23), С. 4118 - 4118

Опубликована: Ноя. 28, 2024

Background: Chronic obstructive pulmonary disease (COPD) is a progressive, inflammatory airway disorder characterized by gradual decline in lung function and increased oxidative stress. Both stress inflammation are central to its pathophysiology, with trace elements such as zinc, copper, iron, manganese, magnesium, selenium, calcium playing key roles various cellular processes. Objective: This article reviews the role of COPD, focusing on their involvement pathogenesis therapeutic potential. Specifically, we examine effects COPD. Methods: We performed comprehensive narrative review literature across databases including PubMed, Web Science, Cochrane Library, Google Scholar, identifying studies that explore The included consisted cohort analyses, randomized controlled trials, clinical investigations. Results: Zinc, critical both pathophysiology management These contribute regulation inflammation, modulation stress, maintenance function. Zinc for instance, reduce modulate immune responses, while iron essential oxygen transport. Magnesium, vital muscle function, respiratory performance, reducing improving Conclusions: minerals may beneficial part standard Maintaining optimal levels these support processes, reduction an improvement However, further research necessary confirm efficacy establish safe dosage recommendations COPD treatment.

Язык: Английский

Процитировано

3
Human herpesvirus reactivation and its potential role in the pathogenesis of post-acute sequelae of SARS-CoV-2 infection DOI Creative Commons
Zsófia Gáspár, Bálint Gergely Szabó, Andrea Ceglédi

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Авг. 29, 2024

The emergence of SARS-CoV-2 has precipitated a global pandemic with substantial long-term health implications, including the condition known as post-acute sequelae infection (PASC), commonly referred to Long COVID. PASC is marked by persistent symptoms such fatigue, neurological issues, and autonomic dysfunction that persist for months beyond acute phase COVID-19. This review examines potential role herpesvirus reactivation, specifically Epstein-Barr virus (EBV) cytomegalovirus (CMV), in pathogenesis PASC. Elevated antibody titers specific T cell responses suggest recent reactivation some patients, although viremia not consistently detected. exhibits endothelial trophism, directly affecting vascular endothelium contributing microvascular pathologies. These pathologies are significant PASC, where may underlie various chronic symptoms. Similarly, herpesviruses like CMV also exhibit which exacerbate damage when reactivated. Evidence suggests EBV could indirectly contribute immune dysregulation, immunosenescence, autoimmune observed Additionally, play genesis through creating mitochondrial dysfunction, though direct confirmation remains elusive. reviewed evidence while their indirect effects, especially context involvement, warrant further investigation.

Язык: Английский

Процитировано

1
Novel biomarkers of mitochondrial dysfunction in Long COVID patients DOI Creative Commons
Titanilla Szögi, Barbara N. Borsos,

Dejana Masic

и другие.

GeroScience, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 4, 2024

Abstract Coronavirus disease 2019 (COVID-19) can lead to severe acute respiratory syndrome, and while most individuals recover within weeks, approximately 30–40% experience persistent symptoms collectively known as Long COVID, post-COVID-19 or post-acute sequelae of syndrome coronavirus 2 (SARS-CoV-2) infection (PASC). These enduring symptoms, including fatigue, difficulties, body pain, short-term memory loss, concentration issues, sleep disturbances, persist for months. According recent studies, SARS-CoV-2 causes prolonged disruptions in mitochondrial function, significantly altering cellular energy metabolism. Our research employed transmission electron microscopy reveal distinct structural abnormalities COVID patients, notably significant swelling, disrupted cristae, an overall irregular morphology, which indicates distress. We noted increased levels superoxide dismutase 1 signals oxidative stress elevated autophagy-related 4B cysteine peptidase levels, indicating mitophagy. Importantly, our analysis also identified reduced circulating cell-free DNA (ccf-mtDNA) these serving a novel biomarker the condition. findings underscore crucial role dysfunction pathogenesis COVID. Further exploration molecular mechanisms underlying post-viral is critical, particularly understand roles autoimmune reactions reactivation latent viruses perpetuating conditions. This comprehensive understanding could pave way targeted therapeutic interventions designed alleviate chronic impacts By utilizing ccf-mtDNA other biomarkers, we enhance diagnostic capabilities improve management this complex syndrome.

Язык: Английский

Процитировано

1