Association between red and processed meat consumption and colorectal cancer risk: a comprehensive meta-analysis of prospective studies
GeroScience,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
Abstract
Increasing
evidence
suggests
that
red
and
processed
meat
consumption
may
elevate
the
risk
of
colorectal
cancer
(CRC),
yet
magnitude
consistency
this
association
remain
debated.
This
meta-analysis
aims
to
quantify
relationship
between
intake
CRC,
colon
cancer,
rectal
using
most
comprehensive
set
prospective
studies
date.
We
conducted
a
search
in
PubMed,
Web
Science,
Cochrane
Library,
Embase,
Google
Scholar
databases
from
1990
November
2024,
identify
relevant
examining
red,
processed,
total
relation
colorectal,
colon,
risk.
Hazard
ratios
(HR)
95%
confidence
intervals
(CI)
were
extracted
for
each
study
pooled
random-effects
model
account
variability
among
studies.
Statistical
evaluation
was
executed
online
platform
MetaAnalysisOnline.com.
A
60
included.
Red
associated
with
significantly
increased
(HR
=
1.22,
CI
1.15–1.30),
1.15,
1.10–1.21),
1.07–1.39).
Processed
showed
similar
associations
1.13,
1.07–1.20),
1.21,
1.14–1.28),
1.17,
1.05–1.30).
Total
also
correlated
an
elevated
1.11–1.35),
1.12–1.22),
1.28,
1.10–1.48).
provides
robust
high
meats
is
cancers.
These
findings
reinforce
current
dietary
recommendations
advocating
limitation
as
part
prevention
strategies.
Язык: Английский
Inadequate sleep increases stroke risk: evidence from a comprehensive meta-analysis of incidence and mortality
GeroScience,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Abstract
The
link
between
abnormal
sleep
duration
and
stroke
outcomes
remains
contentious.
This
meta-analysis
quantifies
how
both
short
long
durations
impact
incidence
mortality.
A
comprehensive
search
was
conducted
in
PubMed,
Web
of
Science,
Cochrane
Library,
Embase,
Google
Scholar
up
to
November
1,
2024,
identify
cohort
studies
evaluating
outcomes.
Meta-analysis
performed
using
MetaAnalysisOnline.com
a
random-effects
model
estimate
pooled
hazard
ratios
(HRs).
Results
were
visualized
through
Forest
Funnel
plots.
Analysis
43
(35
on
incidence,
8
mortality)
revealed
significant
associations
Short
(≤
5–6
h)
associated
with
increased
(HR
1.29,
95%
CI
1.19–1.40,
p
<
0.01)
modestly
elevated
mortality
1.12,
1.01–1.25,
=
0.03).
Long
(>
8–9
demonstrated
stronger
1.46,
1.33–1.60,
1.45,
1.31–1.60,
0.01).
Significant
heterogeneity
observed
(
I
2
74–75%),
while
analyses
showed
moderate
low
35–40%).
highlights
U-shaped
association
risk,
linked
higher
These
findings
underscore
the
importance
balanced
as
modifiable
risk
factor
prevention
strategies
provide
foundation
for
Semmelweis
Study,
prospective
workplace
investigating
role
lifestyle
factors
unhealthy
cerebrovascular
brain
aging.
Язык: Английский
Imbalanced sleep increases mortality risk by 14–34%: a meta-analysis
GeroScience,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Abstract
Sleep
duration
is
a
crucial
factor
influencing
health
outcomes,
yet
its
relationship
with
mortality
remains
debated.
In
this
meta-analysis,
we
aimed
to
investigate
the
association
between
short
and
long
sleep
all-cause
in
adults,
including
sex-specific
differences.
A
systematic
search
was
performed
multiple
databases,
PubMed,
Cochrane
Central,
Web
of
Science,
up
October
2024.
Retrospective
prospective
cohort
studies
involving
adults
at
least
1
year
follow-up
data
on
were
included.
Hazard
ratios
pooled
using
random-effects
model,
subgroup
analyses
based
sex
categories.
total
79
included,
stratified
by
categorized
into
durations.
Short
(<
7
h
per
night)
associated
14%
increase
risk
compared
reference
7–8
h,
hazard
ratio
1.14
(95%
CI
1.10
1.18).
Conversely,
(≥
9
34%
higher
mortality,
1.34
1.26
1.42).
Sex-specific
indicated
that
both
durations
significantly
elevated
men
women,
although
effect
more
pronounced
for
women.
Both
are
increased
though
degree
varies
sex.
These
findings
underscore
importance
considering
optimal
public
strategies
enhancing
longevity
highlight
need
approaches
research.
Язык: Английский
Vitamin D: What role in obesity-related cancer?
Seminars in Cancer Biology,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 1, 2025
Язык: Английский
Treatment delay significantly increases mortality in colorectal cancer: a meta-analysis
GeroScience,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 8, 2025
Abstract
Delaying
the
initiation
of
cancer
treatment
increases
risk
mortality,
particularly
in
colorectal
(CRC),
which
is
among
most
common
and
deadliest
malignancies.
This
study
aims
to
explore
impact
delays
on
mortality
CRC.
A
systematic
literature
search
was
conducted
PubMed,
Web
Science,
Scopus
for
studies
published
between
2000
2025.
Meta-analyses
were
performed
using
random-effects
models
with
inverse
variance
method
calculate
hazard
ratios
(HRs)
both
overall
cancer-specific
survival
at
4-,
8-,
12-week
delay
intervals,
heterogeneity
assessed
through
I
2
-statistics
publication
bias
evaluated
funnel
plots
Egger’s
test.
total
20
relevant
included
meta-analysis.
The
analyses
all
patients
demonstrated
a
progressively
increasing
12–39%
longer
(4
weeks,
HR
=
1.12;
95%
CI,
1.08–1.16;
8
1.24;
1.16–1.34;
12
1.39;
1.25–1.55).
In
particular,
incrementally
higher
observed
all–cause
4
weeks
(HR
1.14;
1.09–1.18),
1.29;
1.20–1.39),
1.47;
1.31–1.64).
contrast,
analysis
showed
similar
trend
but
did
not
reach
statistical
significance
1.07;
0.98–1.18;
1.15;
0.95–1.39;
1.23;
0.93–1.63).
Treatment
associated
worsening
survival,
each
4-week
increment
leading
substantially
risk.
suggests
that
timely
should
be
prioritized
clinical
practice,
as
these
efforts
can
lead
substantial
improvements
rates.
Язык: Английский
The multifaceted role of agents counteracting metabolic syndrome: A new hope for gastrointestinal cancer therapy
Pharmacology & Therapeutics,
Год журнала:
2025,
Номер
unknown, С. 108847 - 108847
Опубликована: Апрель 1, 2025
Язык: Английский
Obesity and Cancer: Excess Body Fat as a Risk Factor in Carcinogenesis; Consequences Across Human Body Systems and Significance for Associated Medical Specialties
European Journal of Medical and Health Research,
Год журнала:
2025,
Номер
3(2), С. 122 - 135
Опубликована: Март 23, 2025
Obesity
is
a
known
risk
factor
for
various
cancers,
influencing
carcinogenesis
through
metabolic,
hormonal,
and
inflammatory
pathways.
Excess
adiposity
leads
to
insulin
resistance,
chronic
inflammation,
hormonal
imbalances,
all
of
which
contribute
tumor
development.
increases
the
cancers
in
endocrine
system
(e.g.,
thyroid,
pancreatic,
adrenal)
due
resistance
altered
hormone
levels.
In
reproductive
system,
it
raises
breast,
ovarian,
endometrial,
prostate
dysregulation
inflammation.
also
linked
digestive
including
esophageal,
liver,
colorectal
metabolic
dysfunction
The
role
obesity
lung
cancer
remains
debated,
but
changes
may
influence
progression.
contributes
hematologic
such
as
leukemia,
by
altering
immune
function
promoting
Other
systems
show
varying
associations
with
risk.
Key
mechanisms
include
dysregulation,
epigenetic
changes,
elevated
insulin/IGF-1,
promote
growth.
Early
detection
imaging
biomarkers,
along
lifestyle
diet,
exercise)
pharmacologic
treatments
metformin,
GLP-1
agonists),
can
reduce
improve
outcomes.
Personalized
treatment
obese
patients
requires
adjustments
surgery,
chemotherapy,
radiotherapy,
immunotherapy.
This
review
explores
obesity’s
association
across
body
systems,
overviews
contributing
carcinogenesis,
summarizes
clinical
public
health
implications,
screening,
prevention,
treatment,
policy
interventions.
Язык: Английский
Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications
Nutrients,
Год журнала:
2025,
Номер
17(8), С. 1351 - 1351
Опубликована: Апрель 15, 2025
Vitamin
D
plays
a
crucial
role
in
the
regulation
of
immune
system,
with
immunomodulatory
effects
that
are
key
prevention
colorectal
cancer
(CRC).
Over
past
decades,
research
has
shown
this
steroid
hormone
impacts
much
more
than
bone
health,
significantly
influencing
responses.
enhances
organ
functions
such
as
spleen
and
lymph
nodes,
boosts
T-cell
activity,
which
is
essential
defending
body
against
tumors.
Additionally,
vitamin
mitigates
inflammatory
responses
closely
linked
to
development,
reducing
inflammation
contributes
CRC.
It
acts
via
receptors
(VDRs)
expressed
on
cells,
modulating
Adequate
levels
influence
gene
expression
related
cell
proliferation,
inhibiting
tumor
development.
also
activates
mechanisms
suppress
survival,
migration,
metastasis.
Low
have
been
associated
an
increased
risk
CRC,
deficiency
correlating
higher
disease
incidence.
Lifestyle
factors,
diet
high
red
meat
calories
but
low
fiber,
fruits,
vegetables,
well
physical
inactivity,
contribute
CRC
risk.
Insufficient
calcium
intake
occurrence
poorer
clinical
outcomes.
Maintaining
optimal
adequate
dietary
preventing
improving
patient
prognosis.
This
review
explores
summarizes
findings
from
randomized
trials
assessing
supplementation
Язык: Английский
Chemopreventive Effects of Piper betle (Sirih) on High-Fat Diet-Induced and Azoxymethane-Induced Colon Cancer in Male Sprague-Dawley Rats
Cureus,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 23, 2024
A
high-fat
diet
could
lead
to
obesity,
increasing
colorectal
cancer
risk
due
dyslipidemia
and
chronic
inflammation,
while
Piper
betle
(PB)
exhibits
anti-tumor,
anti-inflammation,
anti-oxidant
benefits.
This
study
aimed
determine
whether
PB
possesses
chemopreventive
effects
on
(HFD)-induced
azoxymethane
(AOM)-induced
colon
cancer.
Male
Sprague-Dawley
rats
receiving
either
a
normal
or
HFD
were
divided
into
control,
PB,
AOM,
AOM+PB
subgroups
which
then
sacrificed
after
24
weeks.
The
lipid
profile,
leptin,
inflammatory
markers
measured
from
serum,
aberrant
crypt
foci
(ACF)
in
the
detected
by
methylene
blue
staining.
Cellular
proliferation
was
identified
through
immunohistochemical
staining
of
antigen
Kiel
67
(Ki67)
beta-catenin.
There
significant
differences
serum
total
cholesterol,
low-density
lipoprotein,
triglycerides,
high-density
lipoprotein
compared
group.
AOM
group
for
exhibited
significantly
increased
interleukin-6,
IL-12p70,
tumor
necrosis
factor-α,
nuclear
factor-κB,
with
overexpression
Ki67
These
changes
reversed
supplementation.
In
conclusion,
demonstrated
lipid-modifying
against
AOM-induced
rats.
Язык: Английский