Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications
Nutrients,
Год журнала:
2025,
Номер
17(8), С. 1351 - 1351
Опубликована: Апрель 15, 2025
Vitamin
D
plays
a
crucial
role
in
the
regulation
of
immune
system,
with
immunomodulatory
effects
that
are
key
prevention
colorectal
cancer
(CRC).
Over
past
decades,
research
has
shown
this
steroid
hormone
impacts
much
more
than
bone
health,
significantly
influencing
responses.
enhances
organ
functions
such
as
spleen
and
lymph
nodes,
boosts
T-cell
activity,
which
is
essential
defending
body
against
tumors.
Additionally,
vitamin
mitigates
inflammatory
responses
closely
linked
to
development,
reducing
inflammation
contributes
CRC.
It
acts
via
receptors
(VDRs)
expressed
on
cells,
modulating
Adequate
levels
influence
gene
expression
related
cell
proliferation,
inhibiting
tumor
development.
also
activates
mechanisms
suppress
survival,
migration,
metastasis.
Low
have
been
associated
an
increased
risk
CRC,
deficiency
correlating
higher
disease
incidence.
Lifestyle
factors,
diet
high
red
meat
calories
but
low
fiber,
fruits,
vegetables,
well
physical
inactivity,
contribute
CRC
risk.
Insufficient
calcium
intake
occurrence
poorer
clinical
outcomes.
Maintaining
optimal
adequate
dietary
preventing
improving
patient
prognosis.
This
review
explores
summarizes
findings
from
randomized
trials
assessing
supplementation
Язык: Английский
Energy Metabolism and Brain Aging: Strategies to Delay Neuronal Degeneration
Cellular and Molecular Neurobiology,
Год журнала:
2025,
Номер
45(1)
Опубликована: Апрель 21, 2025
Abstract
Aging
is
characterized
by
a
gradual
decline
in
physiological
functions,
with
brain
aging
being
major
risk
factor
for
numerous
neurodegenerative
diseases.
Given
the
brain’s
high
energy
demands,
maintaining
an
adequate
ATP
supply
crucial
its
proper
function.
However,
advancing
age,
mitochondria
dysfunction
and
deteriorating
metabolism
lead
to
reduced
overall
production
impaired
mitochondrial
quality
control
(MQC).
As
result,
promoting
healthy
has
become
key
focus
contemporary
research.
This
review
examines
relationship
between
aging,
highlighting
connection
MQC
metabolism,
proposes
strategies
delay
targeting
metabolism.
Язык: Английский