Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish DOI Creative Commons
Emma K. Costa, Jingxun Chen, Ian H. Guldner

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Abstract Aging is associated with progressive tissue dysfunction, leading to frailty and mortality. Characterizing aging features, such as changes in gene expression dynamics, shared across tissues or specific each tissue, crucial for understanding systemic local factors contributing the process. We performed RNA-sequencing on 13 at 6 different ages African turquoise killifish, shortest-lived vertebrate that can be raised captivity. This comprehensive, sex-balanced ‘atlas’ dataset reveals varying strength of sex-age interactions killifish identifies age-altered biological pathways are evolutionarily conserved. Demonstrating utility this resource, we discovered head kidney exhibits a myeloid bias during aging, phenomenon more pronounced females than males. In addition, developed tissue-specific ‘transcriptomic clocks’ identified biomarkers predictive chronological age. show importance sex-specific clocks selected use evaluate dietary intervention killifish. Our work provides comprehensive resource studying dynamics powerful model.

Язык: Английский

Multi-tissue transcriptomic aging atlas reveals predictive aging biomarkers in the killifish DOI Creative Commons
Emma K. Costa, Jingxun Chen, Ian H. Guldner

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Abstract Aging is associated with progressive tissue dysfunction, leading to frailty and mortality. Characterizing aging features, such as changes in gene expression dynamics, shared across tissues or specific each tissue, crucial for understanding systemic local factors contributing the process. We performed RNA-sequencing on 13 at 6 different ages African turquoise killifish, shortest-lived vertebrate that can be raised captivity. This comprehensive, sex-balanced ‘atlas’ dataset reveals varying strength of sex-age interactions killifish identifies age-altered biological pathways are evolutionarily conserved. Demonstrating utility this resource, we discovered head kidney exhibits a myeloid bias during aging, phenomenon more pronounced females than males. In addition, developed tissue-specific ‘transcriptomic clocks’ identified biomarkers predictive chronological age. show importance sex-specific clocks selected use evaluate dietary intervention killifish. Our work provides comprehensive resource studying dynamics powerful model.

Язык: Английский

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