Functional ultrasound imaging reveals microvascular rarefaction, decreased cerebral blood flow, and impaired neurovascular coupling in a mouse model of paclitaxel-induced chemobrain DOI Creative Commons

Siva Sai Chandragiri,

Ádám Nyúl‐Tóth, Sharon Negri

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Chemotherapy-induced cognitive impairment (CICI), often referred to as "chemobrain," significantly affects the quality of life in cancer survivors. Although traditionally attributed neuronal toxicity, emerging evidence suggests a key role cerebrovascular dysfunction its pathogenesis. We hypothesized that paclitaxel (PTX, Taxol) treatment induces long-term dysfunction, including microvascular rarefaction, impaired neurovascular coupling (NVC), and altered cerebral blood flow (CBF), which contribute CICI. Using clinically relevant PTX regimen non-tumor-bearing mice, we evaluated effects on health. Ultrasound localization microscopy (ULM) functional ultrasound imaging (fUS) were employed assess density, CBF, NVC. resulted significant reduction density cortex hippocampus, regions involved function. reduced velocity middle artery. Moreover, NVC responses, evidenced by diminished CBF increase response whisker stimulation, indicative reactive hyperemia. In conclusion, these findings demonstrate long-lasting NVC, dynamics, likely This study underscores critical health function highlights potential targeting pathways therapeutic approach for mitigating chemotherapy-induced deficits.

Язык: Английский

Functional ultrasound imaging reveals microvascular rarefaction, decreased cerebral blood flow, and impaired neurovascular coupling in a mouse model of paclitaxel-induced chemobrain DOI Creative Commons

Siva Sai Chandragiri,

Ádám Nyúl‐Tóth, Sharon Negri

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Март 25, 2025

Chemotherapy-induced cognitive impairment (CICI), often referred to as "chemobrain," significantly affects the quality of life in cancer survivors. Although traditionally attributed neuronal toxicity, emerging evidence suggests a key role cerebrovascular dysfunction its pathogenesis. We hypothesized that paclitaxel (PTX, Taxol) treatment induces long-term dysfunction, including microvascular rarefaction, impaired neurovascular coupling (NVC), and altered cerebral blood flow (CBF), which contribute CICI. Using clinically relevant PTX regimen non-tumor-bearing mice, we evaluated effects on health. Ultrasound localization microscopy (ULM) functional ultrasound imaging (fUS) were employed assess density, CBF, NVC. resulted significant reduction density cortex hippocampus, regions involved function. reduced velocity middle artery. Moreover, NVC responses, evidenced by diminished CBF increase response whisker stimulation, indicative reactive hyperemia. In conclusion, these findings demonstrate long-lasting NVC, dynamics, likely This study underscores critical health function highlights potential targeting pathways therapeutic approach for mitigating chemotherapy-induced deficits.

Язык: Английский

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