Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications DOI Open Access
Mónika Fekete, Andrea Ceglédi,

Ágnes Szappanos

и другие.

Nutrients, Год журнала: 2025, Номер 17(8), С. 1351 - 1351

Опубликована: Апрель 15, 2025

Vitamin D plays a crucial role in the regulation of immune system, with immunomodulatory effects that are key prevention colorectal cancer (CRC). Over past decades, research has shown this steroid hormone impacts much more than bone health, significantly influencing responses. enhances organ functions such as spleen and lymph nodes, boosts T-cell activity, which is essential defending body against tumors. Additionally, vitamin mitigates inflammatory responses closely linked to development, reducing inflammation contributes CRC. It acts via receptors (VDRs) expressed on cells, modulating Adequate levels influence gene expression related cell proliferation, inhibiting tumor development. also activates mechanisms suppress survival, migration, metastasis. Low have been associated an increased risk CRC, deficiency correlating higher disease incidence. Lifestyle factors, diet high red meat calories but low fiber, fruits, vegetables, well physical inactivity, contribute CRC risk. Insufficient calcium intake occurrence poorer clinical outcomes. Maintaining optimal adequate dietary preventing improving patient prognosis. This review explores summarizes findings from randomized trials assessing supplementation

Язык: Английский

Vitamin D and Colorectal Cancer Prevention: Immunological Mechanisms, Inflammatory Pathways, and Nutritional Implications DOI Open Access
Mónika Fekete, Andrea Ceglédi,

Ágnes Szappanos

и другие.

Nutrients, Год журнала: 2025, Номер 17(8), С. 1351 - 1351

Опубликована: Апрель 15, 2025

Vitamin D plays a crucial role in the regulation of immune system, with immunomodulatory effects that are key prevention colorectal cancer (CRC). Over past decades, research has shown this steroid hormone impacts much more than bone health, significantly influencing responses. enhances organ functions such as spleen and lymph nodes, boosts T-cell activity, which is essential defending body against tumors. Additionally, vitamin mitigates inflammatory responses closely linked to development, reducing inflammation contributes CRC. It acts via receptors (VDRs) expressed on cells, modulating Adequate levels influence gene expression related cell proliferation, inhibiting tumor development. also activates mechanisms suppress survival, migration, metastasis. Low have been associated an increased risk CRC, deficiency correlating higher disease incidence. Lifestyle factors, diet high red meat calories but low fiber, fruits, vegetables, well physical inactivity, contribute CRC risk. Insufficient calcium intake occurrence poorer clinical outcomes. Maintaining optimal adequate dietary preventing improving patient prognosis. This review explores summarizes findings from randomized trials assessing supplementation

Язык: Английский

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