Bionatura,
Год журнала:
2022,
Номер
7(3), С. 1 - 9
Опубликована: Сен. 15, 2022
The
Covid-19
pandemic
revealed
a
complex
health
problem
for
people
and
national
systems.
Faced
with
the
initial
ignorance
of
behavior
SARS-COV-2
virus
in
populations,
turned
to
relief
alternative
medicines.
In
Ecuador,
use
traditional
or
western
medicine
systematic
approach
conventional
are
evident
realities.
Our
work
aimed
assess
knowledge,
attitudes
practices
regarding
formal
treat
disease
contagion.
An
open,
personal
confidential
survey
was
carried
out,
158
questions
on
general
data,
ethnicity,
status,
covid-19
tests,
self-medication,
medicinal
plants
other
chemical
products,
antibiotics
antiparasitics,
among
data.
control
patients,
six
months
after
finishing
survey,
they
were
asked
about
acceptance
vaccine
decision
be
vaccinated
not.
results
3,000
persons
(50%
female
50%
male)
show
frequent
medicine,
even
personnel
university
studies.
study's
conclusions
reflect
that
choose
any
therapies
have
access
mix
treatments
ones
unproven
toxic.
Keywords:
attitudes,
practices,
covid-19,
Journal of Biomolecular Structure and Dynamics,
Год журнала:
2022,
Номер
41(14), С. 6834 - 6844
Опубликована: Авг. 17, 2022
Panduratin
A
(Pa-A)
is
a
prenylated
cyclohexenyl
chalcone
isolated
from
the
rhizomes
of
medicinal
and
culinary
plant
Boesenbergia
rotunda
(L.)
Mansf.,
commonly
called
fingerroots.
Both
an
ethanolic
extract
Pa-A
have
shown
marked
antiviral
activity
against
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2),
responsible
for
COVID-19
pandemic
disease.
functions
as
protease
inhibitor
inhibiting
infection
human
cells
by
virus.
We
modeled
interaction
Pa-A,
26
panduratin
analogues
with
main
(Mpro)
SARS-CoV-2
using
molecular
docking.
The
natural
product
4-hydroxypanduratin
showed
higher
Mpro
binding
capacity
than
isopanduratin
A.
MPro
all
known
derivatives
(Pa-A
to
Pa-Y)
been
compared,
together
more
60
reference
products.
Three
compounds
emerged
potential
robust
binders:
Pa-R,
Pa-V,
Pa-S,
significantly
4-OH-Pa-A
Pa-A.
empirical
energy
(ΔE)
calculated
best
compound
in
series,
Pa-R
bound
Mpro,
surpassed
that
measured
top
inhibitors
such
ruprintrivir,
lufotrelvir,
glecaprevir.
Structure-binding
relationships
are
discussed.
Compounds
flavanone
moiety
(PA-R/S)
binders,
better
those
chromene
unit
(Pa-F/G).
extended
molecules
(such
Pa-V)
exhibit
good
binding,
but
dimeric
Pa-Y
too
long
protrudes
outside
cavity.
work
provides
novel
ideas
guide
design
new
interacting
Mpro.Communicated
Ramaswamy
H.
Sarma.Panduratin
bioactive
molecule
extracts
rotunda.Extracts
B.
virus
SARS-CoV-2.We
27
virus.Three
(Pa-R/V/S)
revealed
high
compared
compounds.Structure–binding
discussed,
treat
COVID-19.
Phytochemical Analysis,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 12, 2024
ABSTRACT
Introduction
Existing
methods
for
morphological,
organoleptic,
and
chemical
authentication
may
not
adequately
ensure
the
accurate
identification
of
plant
species
or
guarantee
safety.
Herbal
raw
material
remains
a
major
challenge
in
herbal
medicine.
Over
past
decade,
DNA
barcoding,
combined
with
an
orthogonal
approach
integrating
various
testing
quality
assurance,
has
emerged
as
new
trend
authentication.
Objective
The
review
evaluates
barcoding
common
alternative
plant‐related
sectors
to
enhance
assurance
Method
Studies
were
selected
based
on
their
relevance
identification,
safety
products.
Inclusion
criteria
peer‐reviewed
articles,
systematic
reviews,
relevant
case
studies
from
last
two
decades
focused
methods,
applications.
Exclusion
involved
lacking
empirical
data,
those
peer‐reviewed,
unrelated
main
focus.
This
ensured
inclusion
high‐quality,
pertinent
sources
while
excluding
less
studies.
Results
An
refers
use
multiple,
independent
that
provide
complementary
information
more
assurance.
reduces
false
positives
negatives
by
confirming
results
through
different
techniques,
combining
morphological
analysis
profiling.
It
enhances
confidence
results,
particularly
cases
potential
adulteration
misidentification
materials.
Conclusion
study
highlights
persistent
challenges
assuring
quality,
purity,
Additionally,
it
stresses
importance
incorporating
DNA‐based
alongside
traditional
identification.
Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Авг. 2, 2023
Abstract
Background:
Self-medication
with
natural
products
during
disease
outbreaks
is
a
major
public
health
challenge
in
developing
countries.
Unlike
self-medication
Over
the
counter
(OTC)
medication
which
receives
significant
attention
published
literature,
have
implications,
especially
times
of
are
yet
to
be
fully
explored.
Not
backed
by
scientific
evidence,
act
can
lead
false
sense
security
among
people,
leading
further
spread
amongst
other
implications.
People
need
informed
about
risks
and
professionally
prescribed
benefits
seek
appropriate
medical
care
when
necessary.
Objectives:
The
purpose
this
dissertation
assess
implications
people
It
tries
answer
following
questions:
(1)
what
state
quality
evidence
current
literature
(2)
gaps
(3)
determinants
contributing
factors
countries
(4)
(5)
possible
solutions?
Method:
This
was
conducted
using
modified
systematic
review
methodology.
search
protocol
utilised
for
selection
relevant
materials
from
used
synthesising
findings
study
documented
PRISMA.
database
result
selected
after
application
limiters,
duplicate
removals,
exclusion
inclusion
criteria,
full-text
review,
screening.
final
articles
were
assessed
bias
20
points
system
AXIS
critical
evaluation
tool.
Data
extracted
into
themes
Microsoft
word
table
synthesised.
Findings:
initial
yielded
1,683
reports
review.
Overall,
71.4%
14
accrued
15
or
more
on
tool,
indicating
that
they
relatively
good
quality.
While
all
twenty
(20)
mentioned
at
least
three
outbreaks,
only
six
(6)
one
therefore
demonstrating
there
dearth
regard,
needs
exploration.
indicate
women
likely
self-medicate
than
men,
acquisition
ideological
had
most
influence
while
common
side
effects
Diarrhoea,
Stomach
pain,
Sweating,
Headache,
Nausea/vomiting.
Findings
steam
inhalation
herbal
baths
increased
risk
COVID-19
infection
who
withdrawn
less
communication
their
physicians.
These
may
suffer
not
reported
doctor
might
account
paucity
outbreaks.
Conclusion
implication
key
finding:
use
outbreak
rampant
practice
readily
available,
accessible,
affordable,
potential
products'
self-medication.
this,
encouraged
speak
predicaments
support
Self-medication
with
natural
products
during
disease
outbreaks
in
developing
countries
poses
significant
public
health
challenges
yet
remains
relatively
unexplored
the
published
literature.
This
study
aims
to
assess
implications
of
such
practices,
address
state
and
quality
evidence,
identify
gaps
literature,
explore
determinants
contributing
factors,
elucidating
implications,
propose
possible
solutions.
Using
a
modified
systematic
literature
review
methodology,
20
articles
were
selected
from
1,683
reports
after
applying
rigorous
selection
criteria
assessment
using
AXIS
critical
evaluation
tool.
The
findings
revealed
dearth
concerning
self-medication
outbreaks,
highlighting
need
for
further
investigation
this
domain.
Key
included
gender,
acquisition,
ideological
while
common
side
effects
comprised
diarrhoea,
stomach
pain,
sweating,
headache,
nausea/vomiting.
Notably,
was
associated
reduced
communication
healthcare
providers,
leading
underreported
effects.
It
also
creates
false
sense
safety
which
may
potentially
exacerbate
spread
prevailing
disease.
In
conclusion,
rampant
use
necessitates
increased
awareness
among
population,
encouraging
individuals
seek
professional
medical
care
support
when
faced
outbreaks.
Pharmacological Research - Modern Chinese Medicine,
Год журнала:
2024,
Номер
11, С. 100434 - 100434
Опубликована: Апрель 28, 2024
To
explore
the
clinical
efficacy
and
safety
of
Xuanfei
Touxie
Fang
(XFTXF)
as
a
complementary
medicine
in
treatment
SARS-CoV-2
Omicron
variant.
A
retrospective
study
317
patients
with
ordinary
symptoms
admitted
to
our
hospital
from
December
2022
February
2023
were
divided
into
observation
group
(n=224)
control
(n=93).
The
was
treated
combined
conventional
alone.
Recovery
time
symptoms,
length
stay,
cure
rate
recovery
chest
CT
manifestations
compared
between
two
groups.
recover
fever
(median:
1
vs
3
days)
stay
7
9
after
significantly
shorter
than
group.
difference
statistically
significant
(P
<
0.05).
(68.3%
54.84%)
(87.95%
66.67%)
higher
There
no
adverse
reactions
during
for
>
Numerous
studies
have
demonstrated
that
Fang,
which
is
frequently
used
respiratory
diseases,
has
anti-coronavirus
effects
by
inhibiting
viral
replication,
release,
penetration,
RNA
synthesis.
Therefore,
we
COVID-19
it
evaluated
its
effectiveness.
effect
COVID-19,
can
reduce
duration
improve
manifestations.
Frontiers in Drug Discovery,
Год журнала:
2022,
Номер
2
Опубликована: Авг. 26, 2022
The
disease
which
is
today
known
as
COVID-19
caused
by
severe
acute
respiratory.
Syndrome
coronavirus
2
(SARS-COV-2),
was
first
reported
in
Wuhan,
China
December
2019.
has
claimed
well
over
six
million
lives
from
500
cases.
Vaccine
hesitancy
militates
against
successful
mass
vaccination.
There
the
rapid
emergence
of
new
SARS-COV-2
variants,
constituting
a
challenge
to
effectiveness
vaccines.
Moreover,
none
available
vaccines
offers
100%
protection
and
even
offered
short
duration
necessitating
booster
doses
be
taken.
Moving
forward,
development
plant-based
edible
will
remarkable
strategic
approach
overcome
vaccine
improve
uptake.
So
far
only
about
nine
drugs
for
treatment
have
approvals
either
or
both
European
Medicines
Agency
FDA.
While
drug
repurposing
address
emerging
need
early
period
pandemic
been
contextually
very
useful,
investment
it
remains
relatively
low
commercial
reasons
arising
patenting
issues.
Embarking
on
discovery
strategies
targeting
virus
host
factors
appealing
option.
Targeting
druggable
targets
that
are
present
across
viruses,
particularly
coronaviruses,
represents
an
important
strategy
preparedness.
Natural
products
reservoir
chemical
scaffolds
with
huge
potential
novel
entities
therapeutics.
Phytopharming
technology
can
used
accelerated
production
therapeutic
molecules
required
within
periods
time
case
outbreaks.
Nanotechnology
provides
excellent
platforms
formulating
multivalent
pan-viral
medicines
COVID-19.
Taken
together,
this
review
discusses
therapeutics
using
tools
biocomputing,
nanotechnology,
phytopharming
achieve
effective
associated
complications,
including
variants
other
viral
pandemics
may
emerge
re-emerge.