Photocatalytically switchable chemoselective difluoramidation of olefins for the synthesis of diversified difluoro-γ-lactams
Tian-Zheng Cao,
Cai-Jian Nie,
Jing Li
и другие.
Chemical Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
study
demonstrates
a
visible-light-driven
intramolecular
alkene
difluorination
enabling
Heck-type
coupling,
hydrofluoramidation,
and
difunctionalization.
Diverse
difluoro-γ-lactams
were
synthesized
with
high
selectivity
substrate
generality.
Язык: Английский
Photoredox-Catalyzed Direct C(sp2)–H Difluoromethylation of Hydrazones with Difluoromethyltriphenylphosphonium Salt via Aminyl Radical/Polar Crossover
Xiao‐Di Wu,
Wang Li,
Ji‐Yu Tao
и другие.
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 10, 2025
This
study
describes
an
efficacious
and
generally
applicable
synthetic
strategy
for
the
incorporation
of
biologically
physiologically
prominent
difluoromethyl
entity
into
synthetically
crucial
hydrazone
scaffolds
with
bench-stable
easily
accessible
difluoromethyltriphenylphosphonium
bromide.
The
broad
substrate
scope,
excellent
functional
group
compatibility,
feasibility
step
atom
economical
one-pot
manipulation,
environmentally
benign
mild
reaction
conditions
rendered
this
methodology
efficient
tool
preparation
pharmaceutically
fluorine-containing
imino
compounds.
Язык: Английский