Ruthenium-Catalyzed Remote Trifunctionalization of Non-Activated Alkenes via Cyano Migration and meta-C(sp2)–H Functionalization
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 28, 2025
A
novel
Ru-catalyzed
radical-triggered
trifunctionalization
of
hexenenitriles
is
presented,
employing
a
strategy
remote
cyano
group
migration
and
meta-C(sp2)-H
functionalization.
Through
migration,
the
alkenyl
moiety
undergoes
difunctionalization
to
formation
benzylic
radical
intermediate.
This
intermediate
facilitates
para-selective
C-H
bond
addition
relative
C-Ru
within
Ru(III)
complex,
ultimately
enabling
trifunctionalization.
methodology
provides
an
efficient
route
diverse
array
nitrile-containing
compounds
with
broad
functional
compatibility.
Язык: Английский
Copper‐Catalyzed 1,5‐Trifluoromethyl‐thio(seleno)cyanation of 5‐Hexenenitriles with an Intramolecular Cyano Migration
Chemistry - An Asian Journal,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 12, 2025
Abstract
A
copper‐catalyzed
remote
1,5‐trifluoromethyl
thio(seleno)cyanation
of
5‐hexenenitriles
with
an
intramolecular
cyano
migration
has
been
established,
affording
a
variety
CF
3
/CN‐containing
thiocyanates
and
selenocyanates
under
mild
conditions.
The
reaction
features
high
chemo‐
regioselectivities
illustrates
potential
value
in
synthetic
chemistry.
Язык: Английский
Alkylcyanation of unactivated alkenes via photoinduced hydrogen atom transfer and 1,4-cyano migration
Tetrahedron Letters,
Год журнала:
2025,
Номер
159, С. 155516 - 155516
Опубликована: Фев. 27, 2025
Язык: Английский
Functionalized Oxindole Construction via a Cyano Migration and Cyclization Relay Strategy
Bo-Xi Liu,
S. A. A. Shah,
Feng Zhou
и другие.
Organic Letters,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 24, 2025
A
visible-light-induced
trifunctionalization
of
unactivated
alkenes
for
building
functionalized
oxindoles
through
a
radical
cyano
migration
strategy
is
reported.
This
transformation
employs
tandem
alkene
sulfonylation-initiated
migration/cyclization
cascade
process.
features
stable
and
easily
accessible
substrates,
mild
reaction
conditions,
metal-free
catalysts,
the
capability
late-stage
functionalization.
Язык: Английский
Radical Functionalization of 1,6‐Diene via Transannular Cyano Migration: Synthesis of Polysubstituted Cyclopentanes†
Chinese Journal of Chemistry,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 21, 2024
Comprehensive
Summary
An
efficient
transannular
cyano
migration
is
reported
for
gem
‐dicyano‐1,6‐diene,
which
triggered
by
the
addition
of
external
arylsulfonyl
radicals.
The
overall
transformation
proceeds
through
a
sequence
intramolecular
5‐exo‐trig
cyclization,
suprafacial
1,4‐cyano
migration,
and
capture
H
or
D
atom,
leading
to
production
valuable
polysubstituted
cyclopentanes
under
mild
photoredox
catalytic
conditions.
reaction
adapted
wide
range
sodium
(hetero)arylsulfinates,
demonstrating
good
functional
group
compatibility.
This
method
provides
new
protocol
radical‐mediated
migration.
Язык: Английский