Advanced Synthesis & Catalysis, Год журнала: 2024, Номер unknown

Опубликована: Окт. 23, 2024

Abstract The dearomatization of indoles with ynamides is a convenient access towards polycyclic spiroindolines, which can be initiated by α‐ and β‐additions ynamides. Currently, the related β‐addition dearomative cyclization requires noble‐metal catalyst or stoichiometric oxidant. Herein, we report copper‐catalyzed aryl‐substituted indolyl through regioselective onto ynamides, providing pentacyclic spiroindolines in 81–97% yields >25:1 diastereoselectivities. Moreover, preliminary success has been obtained for catalytic enantioselective cyclization.

Язык: Английский