Enantioselective Synthesis of Axially Chiral Alkylidenecycloalkanes via Copper-Catalyzed Functionalization of Acyl Allenols

ACS Catalysis, Год журнала: 2025, Номер unknown, С. 2351 - 2358

Опубликована: Янв. 24, 2025

Язык: Английский

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Chiral phosphoric acid-catalyzed atroposelective oxidative coupling of carbazoles

Science China Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Март 14, 2025

Язык: Английский

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Zr-Catalyzed Assembly of 1,1,1-Triborylalkanes from Alkenes and HBpin

Journal of the American Chemical Society, Год журнала: 2025, Номер unknown

Опубликована: Май 10, 2025

Multiboronated compounds play more and significant roles in the chemical community, 1,1,1-triborylalkanes have emerged as versatile building blocks organic synthesis. However, efficient strategies for assembly of such are very rare. A general atom-economical synthesis from various alkenes with pinacolborane (HBpin) is reported first time. The success this transformation relies on use commercially available Schwartz reagent (Cp2ZrHCl) a catalyst, enabling sequential dehydrogenative borylation hydroboration. This reaction demonstrates excellent selectivity, high yields, broad functional group tolerance. Mechanistic investigations reveal that process begins two consecutive borylations catalyzed by zirconium, producing 1,1-diborylalkene intermediate, which subsequently undergoes hydroboration HBpin to afford 1,1,1-triborylalkanes. Notably, approach allows remote 1,1,1-triboration internal alkenes.

Язык: Английский

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Rh(I)-Catalyzed Modular Synthesis of Axially Chiral Alkylidene Azacycloalkanes

ACS Central Science, Год журнала: 2025, Номер unknown

Опубликована: Май 11, 2025

Язык: Английский

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