Frontiers in Public Health,
Год журнала:
2024,
Номер
12
Опубликована: Март 18, 2024
Objective
The
goal
of
this
study
is
to
compare
the
cost-effectiveness
tislelizumab
and
sorafenib
as
first-line
treatment
for
advanced
hepatocellular
carcinoma
in
China.
Methods
A
comprehensive
analysis
was
undertaken
within
framework
a
partitioned
survival
model
accurately
gage
incremental
ratio
(ICER)
compared
sorafenib.
incorporated
relevant
clinical
data
all
rates
were
from
RATIONALE-301
trials.
stability
assessed
by
performing
one-way
two-way
sensitivity
analyses.
Results
total
cost
incurred
$16181.24,
whereas
$14306.87.
regimen
resulted
significant
increase
0.18
quality-adjusted
life
years
(QALYs)
an
extra
$1874.37
chemotherapy.
ICER
$10413.17
per
QALY,
which
found
be
below
willingness-to-pay
(WTP)
threshold
$37304.34/QALY.
results
that
no
fluctuations
any
factors
affected
our
results,
even
when
these
parameters
fluctuated.
Conclusion
Tislelizumab
appears
cost-effective
These
findings
can
inform
decision-making
processes
regarding
selection
most
option
carcinoma.
Cell Death Discovery,
Год журнала:
2025,
Номер
11(1)
Опубликована: Фев. 8, 2025
Abstract
Histone
lactylation
plays
a
crucial
role
in
cancer
progression,
but
its
impact
on
breast
(BC)
tumorigenesis
is
still
unclear.
We
utilized
chromatin
immunoprecipitation
sequencing
with
H3K18la
antibodies,
transcriptomics
of
clinical
BC
samples,
and
proteomics
ATAC-seq
analyses
vivo
tumors
to
identify
the
genes
regulated
by
transcription
factor
PPARD.
qPCR
Western
blot
assays
were
used
detect
expressions
molecules.
discovered
that
levels
higher
tissues
compared
adjacent
non-cancerous
tissues.
promoted
expression
PPARD,
which
turn
influenced
AKT,
not
ILK.
analysis
revealed
glycolysis
cells
enhanced
accessibility.
Additionally,
we
confirmed
HDAC2
HDAC3
act
as
“erasers”
for
H3
lysine
lactylation.
During
analysis,
AKT-phosphorylation
aerobic
respiration
inhibitor
group
exhibited
an
apparent
disparity
activity.
Our
study
demonstrated
changes
downstream
PPARD
support
cell
survival
under
anaerobic
conditions.
accelerated
proliferation
promoting
phosphorylation
AKT.
This
highlights
therapeutic
potential
targeting
H3K18la/PPARD/AKT
axis
cancer,
providing
new
insights
into
epigenetic
regulation
metabolism
(Trial
registration:
The
was
approved
Research
Ethics
Committee
Shandong
Provincial
Third
Hospital
(KYLL-2023057;
https://www.medicalresearch.org.cn/
)).
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
14(4)
Опубликована: Ноя. 6, 2024
Cancer
remains
one
of
the
most
challenging
health
issues
globally,
demanding
innovative
therapeutic
approaches
for
effective
treatment.
Nanoparticles,
particularly
those
composed
gold,
silver,
and
iron
oxide,
have
emerged
as
promising
candidates
changing
cancer
therapy.
This
comprehensive
review
demonstrates
landscape
nanoparticle-based
oncological
interventions,
focusing
on
remarkable
advancements
potentials
oxide
nanoparticles.
Gold
nanoparticles
garnered
significant
attention
their
exceptional
biocompatibility,
tunable
surface
chemistry,
distinctive
optical
properties,
rendering
them
ideal
various
diagnostic
strategies.
Silver
nanoparticles,
renowned
antimicrobial
exhibit
potential
in
therapy
through
multiple
mechanisms,
including
apoptosis
induction,
angiogenesis
inhibition,
drug
delivery
enhancement.
With
magnetic
properties
offer
unique
diagnosis
targeted
opportunities.
critically
examines
recent
synthesis,
functionalization,
biomedical
applications
these
Moreover,
challenges
are
discussed,
toxicity
concerns,
immunogenicity,
translational
barriers,
ongoing
efforts
to
overcome
hurdles
highlighted.
Finally,
insights
into
future
directions
regulatory
considerations,
provided
aiming
accelerate
translation
technologies
from
bench
bedside.
Frontiers in Oncology,
Год журнала:
2024,
Номер
14
Опубликована: Апрель 4, 2024
The
tumor
microenvironment
is
a
complex
ecosystem
where
various
cellular
and
molecular
interactions
shape
the
course
of
cancer
progression.
Macrophage
colony-stimulating
factor
(M-CSF)
plays
pivotal
role
in
this
context.
This
study
delves
into
biological
properties
functions
M-CSF
regulating
tumor-associated
macrophages
(TAMs)
its
modulating
host
immune
responses.
Through
specific
binding
to
receptor
1
(CSF-1R),
orchestrates
cascade
downstream
signaling
pathways
modulate
macrophage
activation,
polarization,
proliferation.
Furthermore,
extends
influence
other
cell
populations,
including
dendritic
cells.
Notably,
heightened
expression
within
often
associated
with
dismal
patient
prognoses.
Therefore,
comprehensive
investigation
roles
growth
advances
our
comprehension
development
mechanisms
unveils
promising
novel
strategies
approaches
for
treatment.
JAMA Network Open,
Год журнала:
2024,
Номер
7(10), С. e2440381 - e2440381
Опубликована: Окт. 21, 2024
Importance
Timely
analysis
of
cancer
incidence
trends
is
crucial
for
prevention
and
control,
which
a
public
health
priority
in
China.
Objective
To
estimate
32
cancers
China
from
1983
to
2017
project
changes
2032,
assessing
distinct
due
risk
factors
an
aging
population.
Design,
Setting,
Participants
This
population-based
cohort
study
used
data
the
Cancer
Incidence
Five
Continents
database
(1983-2017).
New
cases
were
collected.
Data
analyzed
October
15,
2023,
May
23,
2024.
Main
Outcomes
Measures
Age-standardized
rate
(AIR)
standardized
World
Health
Organization
Standard
Population,
average
annual
percentage
(AAPC)
using
joinpoint
regression,
change
factors,
Møller
decomposition
analysis,
stratified
by
sex.
Results
A
total
3
677
027
new
(54.9%
male,
45.1%
female)
included
analysis.
Increased
AIRS
observed
11
males
14
females
2017,
with
expected
continue
until
2032.
Thyroid
showed
highest
increase
(AAPC:
7.82%
males;
95%
CI,
6.92%-10.38%;
8.59%
females;
7.84%-10.42%),
followed
prostate
(4.71%;
3.12%-9.95%)
kidney
(3.61%;
3.11%-5.82%)
males,
cervical
(4.43%;
3.36%-9.44%)
(3.66%;
2.98%-6.86%)
females.
The
AIRs
lung
tended
decrease
but
during
1983-2017.
In
contrast,
stomach,
liver,
larynx,
nose
sinuses
decreased
From
2018
projected
primarily
18
females,
while
would
be
associated
other
cancers.
Conclusions
Relevance
this
incident
general
population,
landscape
evolving,
increasing
20
others.
Primary
efforts
reduce
exposure
are
crucial,
further
basic
research
needed.
Additionally,
second
imperative
improve
survival,
particularly
among
older
individuals.
Abstract
Background
Colorectal
cancer
(CRC)
is
the
3rd
most
common
malignancy
with
liver
being
site
of
metastases.
The
recurrence
rate
colorectal
metastases
(CRLM)
after
resection
(LR)
notably
high,
an
estimated
40%
patients
experiencing
within
6
months.
In
this
context,
we
conducted
a
meta-analysis
to
synthesize
and
evaluate
reliability
evidence
pertaining
prognostic
factors
associated
early
(ER)
in
CRLM
following
LR.
Methods
Systematic
searches
were
from
inception
databases
July
14,
2023,
identify
studies
reporting
ER.
Quality
Prognostic
Factor
Studies
(QUIPS)
tool
was
employed
assess
risk-of-bias
for
included
studies.
Meta-analysis
then
performed
on
these
factors,
summarized
by
forest
plots.
grading
based
sample
size,
heterogeneity,
Egger’s
P
value.
Results
study
24
investigations,
comprising
12705
individuals,
during
accrual
period
that
extended
2007
2023.
evaluation
risk-of-bias,
22
rated
as
low/moderate
risk,
while
two
excluded
because
high
risk.
Most
used
postoperative
interval
months
define
ER,
30.2%
(95%
confidence
[CI],
24.1–36.4%)
ER
21
pooled
meta-analysis.
High-quality
showed
poor
differentiation
CRC,
larger
bilobar-distributed
metastases,
major
hepatectomy,
positive
surgical
margins,
complications
elevated
risk
Additionally,
moderate-quality
suggested
levels
carcinoembryonic
antigen
(CEA)
carbohydrate
19–9
(CA199),
lymph
node
(LNM)
higher
number
Conclusion
This
review
has
potential
enhance
efficacy
surveillance
strategies,
refine
assessments,
guide
judicious
treatment
decisions
it
essential
undertake
well-designed
prospective
investigations
examine
additional
develop
salvage
therapeutic
approaches
CRLM.
