The identification of tumor antigens and immune subtypes based on the development of immunotherapies targeting head and neck squamous cell carcinomas resulting from periodontal disease DOI Creative Commons

Yangju Fu,

Yongbo Zheng

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Авг. 22, 2023

Among cancer treatments, immunotherapy is considered a promising strategy. Nonetheless, only small number of individuals with head and neck squamous cell carcinoma exhibit positive responses to immunotherapy. This study aims discover possible antigens for carcinoma, create an mRNA vaccine this type cancer, investigate the connection between periodontal disease, determine immune subtype cells affected by carcinoma. To ascertain gene expression profiles clinical data corresponding them, examination was carried out on TCGA database. Antigen-presenting were detected using TIMER. Targeting six immune-related genes (CXCL5, ADM, FGF9, AIMP1, STC1, CDKN2A) in diagnosed has shown results triggered disease. These have been linked improved prognosis increased infiltration. Additionally, CXCL5, CDKN2A exhibited potential as creation vaccine. A nomogram model containing ADM tumor stage constructed practice. summarize, shows candidate biomarker predicting prognosis, molecular features, characteristics cells. Our results, obtained through real-time PCR analysis, showed significant upregulation SCC-25 line compared NOK-SI line. suggests that might be implicated pathogenesis HNSC, highlighting target HNSC treatment. However, further research needed elucidate functional role HNSC. findings provide basis exploration mechanisms underlying could help develop novel therapeutic strategies.

Язык: Английский

Hemin blocks TIGIT/PVR interaction and induces ferroptosis to elicit synergistic effects of cancer immunotherapy DOI
Xiaowen Zhou, Li Yang,

Xiangrui Zhang

и другие.

Science China Life Sciences, Год журнала: 2024, Номер 67(5), С. 996 - 1009

Опубликована: Фев. 1, 2024

Язык: Английский

Процитировано

14
Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects DOI
Y. F. Lu,

Xiao‐Ting Xie,

Lianxiang Luo

и другие.

APOPTOSIS, Год журнала: 2024, Номер 29(11-12), С. 1914 - 1943

Опубликована: Июль 15, 2024

Язык: Английский

Процитировано

7
mRNA‐based Vaccines Targeting the T‐cell Epitope‐rich Domain of Epstein Barr Virus Latent Proteins Elicit Robust Anti‐Tumor Immunity in Mice DOI Creative Commons
Ge‐Xin Zhao,

Guo‐Long Bu,

Gang‐Feng Liu

и другие.

Advanced Science, Год журнала: 2023, Номер 10(35)

Опубликована: Окт. 27, 2023

Abstract Epstein‐Barr virus (EBV) is associated with various malignancies and infects >90% of the global population. EBV latent proteins are expressed in numerous EBV‐associated cancers contribute to carcinogenesis, making them critical therapeutic targets for these cancers. Thus, this study aims develop mRNA‐based vaccines that express T‐cell‐epitope‐rich domain truncated EBV, including truncatedlatent membrane protein 2A (Trunc‐LMP2A), nuclear antigen 1 (Trunc‐EBNA1), Trunc‐EBNA3A. The effectively activate both cellular humoral immunity mice show promising results suppressing tumor progression improving survival time tumor‐bearing mice. Furthermore, it observed forms antigens, Trunc‐LMP2A, Trunc‐EBNA1, Trunc‐EBNA3A, more effective than full‐length antigens activating antigen‐specific immune responses. In summary, findings demonstrate effectiveness targeting providing new treatment options

Язык: Английский

Процитировано

17
Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy DOI Creative Commons

Shengzhe Jin,

Hongfei Wang, Yang Li

и другие.

Cell Communication and Signaling, Год журнала: 2024, Номер 22(1)

Опубликована: Март 11, 2024

Abstract Background Targeting the tumor microenvironment (TME) has emerged as a promising strategy in cancer treatment, particularly through utilization of immune checkpoint blockade (ICB) agents such PD-1/PD-L1 inhibitors. Despite partial success, presence tumor-associated macrophages (TAMs) contributes to an immunosuppressive TME that fosters progression, and diminishes therapeutic efficacy ICB. Blockade CD47/SIRPα pathway proven be effective intervention, restores macrophage phagocytosis yields substantial antitumor effects, especially when combined with blockade. Therefore, identification small molecules capable simultaneously blocking interactions remained imperative. Methods SMC18, molecule capacity targeting both SIRPα PD-L1 was obtained using MST. The efficiency SMC18 interrupting tested by assay. function enhancing activity T cells assay co-culture effects mechanisms were investigated MC38-bearing mouse model. Results dual-targets protein, identified. effectively blocked interaction, thereby restoring phagocytosis, disrupted interactions, thus activating Jurkat cells, evidenced increased secretion IL-2. demonstrated inhibition MC38 growths promoting infiltration CD8 + M1-type into sites, while also priming macrophages. Moreover, combination radiotherapy (RT) further improved efficacy. Conclusion Our findings suggested compound which pathways, could candidate for macrophage- T-cell-mediated responses immunotherapy.

Язык: Английский

Процитировано

5
Expression and Clinical Significance of NUDCD1, PI3K/AKT/mTOR Signaling Pathway-Related Molecules and Immune Infiltration in Breast Cancer DOI Creative Commons
Wei Wen, Yuehua Li, Xi Cao

и другие.

Clinical Breast Cancer, Год журнала: 2024, Номер 24(6), С. e429 - e451

Опубликована: Март 6, 2024

BackgroundNUDCD1 (NudC Domain Containing 1) performs an essential function in biological processes such as cell progression, migration, cycle, and intracellular material transport. Many solid tumors express it highly, which is a prospective biomarker therapeutic approach. However, the expression clinical importance of NUDCD1 across breast cancer unclear.MethodsThe expressions cancers normal tissues were studied utilizing TIMER database immunohistochemical analysis. Subsequently, we validate association between clinicopathologic features prognosis cancer. The experiments pathway-related molecules done on 214 tissue microarrays. investigation correlation tumor immune infiltration was subsequently conducted.ResultsThrough utilization bioinformatics analysis experiments, determined that exhibited upregulation within Furthermore, discovered elevated may potentially be linked to worse Our study reveals PI3K/AKT/mTOR signaling pathway perform regulating progression via enrichment associated with degree immunological infiltration.ConclusionThe explored observed correlated poorer prognosis. p-AKT, PI3K, AKT, mTOR, p-mTOR levels underwent significant elevation might pathway.Micro AbstractBreast one most common malignant women. In this study, analyzed 1226 cases using methods respectively. found highly expressed poor It new target for patients.

Язык: Английский

Процитировано

4
Antifungal immunity: advances in PRR recognition, adaptive responses, and immune-based therapies DOI
Jianlin Zhou, Xinjie Lu,

Rui-Rui He

и другие.

Science China Life Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 5, 2025

Язык: Английский

Процитировано

0
The identification of tumor antigens and immune subtypes based on the development of immunotherapies targeting head and neck squamous cell carcinomas resulting from periodontal disease DOI Creative Commons

Yangju Fu,

Yongbo Zheng

Frontiers in Oncology, Год журнала: 2023, Номер 13

Опубликована: Авг. 22, 2023

Among cancer treatments, immunotherapy is considered a promising strategy. Nonetheless, only small number of individuals with head and neck squamous cell carcinoma exhibit positive responses to immunotherapy. This study aims discover possible antigens for carcinoma, create an mRNA vaccine this type cancer, investigate the connection between periodontal disease, determine immune subtype cells affected by carcinoma. To ascertain gene expression profiles clinical data corresponding them, examination was carried out on TCGA database. Antigen-presenting were detected using TIMER. Targeting six immune-related genes (CXCL5, ADM, FGF9, AIMP1, STC1, CDKN2A) in diagnosed has shown results triggered disease. These have been linked improved prognosis increased infiltration. Additionally, CXCL5, CDKN2A exhibited potential as creation vaccine. A nomogram model containing ADM tumor stage constructed practice. summarize, shows candidate biomarker predicting prognosis, molecular features, characteristics cells. Our results, obtained through real-time PCR analysis, showed significant upregulation SCC-25 line compared NOK-SI line. suggests that might be implicated pathogenesis HNSC, highlighting target HNSC treatment. However, further research needed elucidate functional role HNSC. findings provide basis exploration mechanisms underlying could help develop novel therapeutic strategies.

Язык: Английский

Процитировано

0