Hemin blocks TIGIT/PVR interaction and induces ferroptosis to elicit synergistic effects of cancer immunotherapy
Science China Life Sciences,
Год журнала:
2024,
Номер
67(5), С. 996 - 1009
Опубликована: Фев. 1, 2024
Язык: Английский
Ferroptosis crosstalk in anti-tumor immunotherapy: molecular mechanisms, tumor microenvironment, application prospects
APOPTOSIS,
Год журнала:
2024,
Номер
29(11-12), С. 1914 - 1943
Опубликована: Июль 15, 2024
Язык: Английский
mRNA‐based Vaccines Targeting the T‐cell Epitope‐rich Domain of Epstein Barr Virus Latent Proteins Elicit Robust Anti‐Tumor Immunity in Mice
Advanced Science,
Год журнала:
2023,
Номер
10(35)
Опубликована: Окт. 27, 2023
Abstract
Epstein‐Barr
virus
(EBV)
is
associated
with
various
malignancies
and
infects
>90%
of
the
global
population.
EBV
latent
proteins
are
expressed
in
numerous
EBV‐associated
cancers
contribute
to
carcinogenesis,
making
them
critical
therapeutic
targets
for
these
cancers.
Thus,
this
study
aims
develop
mRNA‐based
vaccines
that
express
T‐cell‐epitope‐rich
domain
truncated
EBV,
including
truncatedlatent
membrane
protein
2A
(Trunc‐LMP2A),
nuclear
antigen
1
(Trunc‐EBNA1),
Trunc‐EBNA3A.
The
effectively
activate
both
cellular
humoral
immunity
mice
show
promising
results
suppressing
tumor
progression
improving
survival
time
tumor‐bearing
mice.
Furthermore,
it
observed
forms
antigens,
Trunc‐LMP2A,
Trunc‐EBNA1,
Trunc‐EBNA3A,
more
effective
than
full‐length
antigens
activating
antigen‐specific
immune
responses.
In
summary,
findings
demonstrate
effectiveness
targeting
providing
new
treatment
options
Язык: Английский
Discovery of a novel small molecule as CD47/SIRPα and PD-1/PD-L1 dual inhibitor for cancer immunotherapy
Cell Communication and Signaling,
Год журнала:
2024,
Номер
22(1)
Опубликована: Март 11, 2024
Abstract
Background
Targeting
the
tumor
microenvironment
(TME)
has
emerged
as
a
promising
strategy
in
cancer
treatment,
particularly
through
utilization
of
immune
checkpoint
blockade
(ICB)
agents
such
PD-1/PD-L1
inhibitors.
Despite
partial
success,
presence
tumor-associated
macrophages
(TAMs)
contributes
to
an
immunosuppressive
TME
that
fosters
progression,
and
diminishes
therapeutic
efficacy
ICB.
Blockade
CD47/SIRPα
pathway
proven
be
effective
intervention,
restores
macrophage
phagocytosis
yields
substantial
antitumor
effects,
especially
when
combined
with
blockade.
Therefore,
identification
small
molecules
capable
simultaneously
blocking
interactions
remained
imperative.
Methods
SMC18,
molecule
capacity
targeting
both
SIRPα
PD-L1
was
obtained
using
MST.
The
efficiency
SMC18
interrupting
tested
by
assay.
function
enhancing
activity
T
cells
assay
co-culture
effects
mechanisms
were
investigated
MC38-bearing
mouse
model.
Results
dual-targets
protein,
identified.
effectively
blocked
interaction,
thereby
restoring
phagocytosis,
disrupted
interactions,
thus
activating
Jurkat
cells,
evidenced
increased
secretion
IL-2.
demonstrated
inhibition
MC38
growths
promoting
infiltration
CD8
+
M1-type
into
sites,
while
also
priming
macrophages.
Moreover,
combination
radiotherapy
(RT)
further
improved
efficacy.
Conclusion
Our
findings
suggested
compound
which
pathways,
could
candidate
for
macrophage-
T-cell-mediated
responses
immunotherapy.
Язык: Английский
Expression and Clinical Significance of NUDCD1, PI3K/AKT/mTOR Signaling Pathway-Related Molecules and Immune Infiltration in Breast Cancer
Clinical Breast Cancer,
Год журнала:
2024,
Номер
24(6), С. e429 - e451
Опубликована: Март 6, 2024
BackgroundNUDCD1
(NudC
Domain
Containing
1)
performs
an
essential
function
in
biological
processes
such
as
cell
progression,
migration,
cycle,
and
intracellular
material
transport.
Many
solid
tumors
express
it
highly,
which
is
a
prospective
biomarker
therapeutic
approach.
However,
the
expression
clinical
importance
of
NUDCD1
across
breast
cancer
unclear.MethodsThe
expressions
cancers
normal
tissues
were
studied
utilizing
TIMER
database
immunohistochemical
analysis.
Subsequently,
we
validate
association
between
clinicopathologic
features
prognosis
cancer.
The
experiments
pathway-related
molecules
done
on
214
tissue
microarrays.
investigation
correlation
tumor
immune
infiltration
was
subsequently
conducted.ResultsThrough
utilization
bioinformatics
analysis
experiments,
determined
that
exhibited
upregulation
within
Furthermore,
discovered
elevated
may
potentially
be
linked
to
worse
Our
study
reveals
PI3K/AKT/mTOR
signaling
pathway
perform
regulating
progression
via
enrichment
associated
with
degree
immunological
infiltration.ConclusionThe
explored
observed
correlated
poorer
prognosis.
p-AKT,
PI3K,
AKT,
mTOR,
p-mTOR
levels
underwent
significant
elevation
might
pathway.Micro
AbstractBreast
one
most
common
malignant
women.
In
this
study,
analyzed
1226
cases
using
methods
respectively.
found
highly
expressed
poor
It
new
target
for
patients.
Язык: Английский
Antifungal immunity: advances in PRR recognition, adaptive responses, and immune-based therapies
Science China Life Sciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 5, 2025
Язык: Английский
The identification of tumor antigens and immune subtypes based on the development of immunotherapies targeting head and neck squamous cell carcinomas resulting from periodontal disease
Frontiers in Oncology,
Год журнала:
2023,
Номер
13
Опубликована: Авг. 22, 2023
Among
cancer
treatments,
immunotherapy
is
considered
a
promising
strategy.
Nonetheless,
only
small
number
of
individuals
with
head
and
neck
squamous
cell
carcinoma
exhibit
positive
responses
to
immunotherapy.
This
study
aims
discover
possible
antigens
for
carcinoma,
create
an
mRNA
vaccine
this
type
cancer,
investigate
the
connection
between
periodontal
disease,
determine
immune
subtype
cells
affected
by
carcinoma.
To
ascertain
gene
expression
profiles
clinical
data
corresponding
them,
examination
was
carried
out
on
TCGA
database.
Antigen-presenting
were
detected
using
TIMER.
Targeting
six
immune-related
genes
(CXCL5,
ADM,
FGF9,
AIMP1,
STC1,
CDKN2A)
in
diagnosed
has
shown
results
triggered
disease.
These
have
been
linked
improved
prognosis
increased
infiltration.
Additionally,
CXCL5,
CDKN2A
exhibited
potential
as
creation
vaccine.
A
nomogram
model
containing
ADM
tumor
stage
constructed
practice.
summarize,
shows
candidate
biomarker
predicting
prognosis,
molecular
features,
characteristics
cells.
Our
results,
obtained
through
real-time
PCR
analysis,
showed
significant
upregulation
SCC-25
line
compared
NOK-SI
line.
suggests
that
might
be
implicated
pathogenesis
HNSC,
highlighting
target
HNSC
treatment.
However,
further
research
needed
elucidate
functional
role
HNSC.
findings
provide
basis
exploration
mechanisms
underlying
could
help
develop
novel
therapeutic
strategies.
Язык: Английский