Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy

Aging and Disease, Год журнала: 2025, Номер unknown, С. 0 - 0

Опубликована: Янв. 1, 2025

The aging immune system presents profound challenges, notably through the decline of T cell function, which is critical for effective responses. As age-related changes lead to diminished diversity and heighten immunosuppressive environments, older individuals face increased susceptibility infections, autoimmune diseases, reduced efficacy immunotherapies. This review investigates intricate mechanisms by drives immunosenescence, including suppression, evasion, antigen reactivity, overexpression checkpoint molecules. By delving into innovative therapeutic strategies aimed at rejuvenating populations modifying immunological landscape, we highlight potential enhancing resilience in elderly. Ultimately, our goal outline actionable pathways restoring thereby improving health outcomes facing decline.

Язык: Английский

RIG-I-driven CDKN1A stabilization reinforces cellular senescence

Science China Life Sciences, Год журнала: 2025, Номер unknown

Опубликована: Март 24, 2025

Язык: Английский

The n-butanol extract of Polygonatum sibiricum improves spleen aging via p53 pathway

Phytomedicine, Год журнала: 2025, Номер unknown, С. 156888 - 156888

Опубликована: Июнь 1, 2025

Язык: Английский