Inorganics,
Год журнала:
2024,
Номер
12(12), С. 325 - 325
Опубликована: Дек. 13, 2024
Bromelain
(Br)
is
a
proteolytic
enzyme
with
various
pharmacological
properties,
such
as
antibacterial,
antioxidant,
anti-inflammatory,
anticancer,
and
anti-angiogenic
properties.
However,
due
to
its
low
solubility
bioavailability,
absorption
low,
so
delivery
mechanism
needed
achieve
the
desired
therapeutic
effects.
was
chemically
synthesized
loaded
onto
gold
nanoparticles
(AuNPs).
Different
methods
techniques
were
used
for
detection
characterization,
including
color-change
detection,
UV
spectroscopy,
XRD,
SEM,
TEM,
FTIR.
The
in
vitro
antioxidant
activity
detected
using
DPPH
assays,
wound-healing
investigated
mice.
current
study
revealed
that
formulated
AuNPs-Br
showed
effective
strongest
demonstrated
by
histopathological
vivo
studies,
Journal of Engineered Fibers and Fabrics,
Год журнала:
2024,
Номер
19
Опубликована: Янв. 1, 2024
Diabetic
wound
healing
remains
a
significant
challenge
due
to
impaired
and
delayed
processes.
Recently,
nanoscaffold
dressings
with
their
intricate
architectures
gained
remarkable
attention
in
regenerative
medicine.
Herein,
electrospun
cellulose
acetate
(CA)
nanofiber
incorporated
various
concentrations
of
bioglass
nanoparticles
(BGNPs)
silver
(AgNPs)
were
prepared
as
novel
nanocomposites
for
possible
diabetic
healing.
The
physico-chemically
characterized
using
scan
electron
microscopy
(SEM),
Fourier
Transform
Infra-Red
Spectroscopy
(FTIR),
Energy-dispersive
X-ray
spectroscopy
(EDX)
Thermogravimetric
analysis
(TGA).
antimicrobial
activities
the
firstly
evaluated
in-vitro
then
in-vivo
against
streptozotocin-induced
rats.
FTIR
EDX
elemental
analyses
confirmed
chemical
structural
composition
CA/BGNPs/AgNPs
dressings.
SEM
revealed
uniform,
smooth
continuous
(40–180
nm
diameter)
that
showed
higher
thermal
stability
indicated
by
TGA
analysis.
3%
BGNPs
5%
AgNPs
loaded
CA
nanofibers
maximal
activity
specifically
gram
positive
Staphylococcus
aureus
(42
±
1.9
mm)
negative
Escherichia
coli
(43
2.2
which
are
main
two
bacteria
infecting
wounds.
In
vivo
study
acceleration
process
combination
efficient
closure
Day
6
without
induction
skin
irritation.
Therefore,
newly
designed
dressing
hold
promising
potential
management
Inorganics,
Год журнала:
2024,
Номер
12(12), С. 325 - 325
Опубликована: Дек. 13, 2024
Bromelain
(Br)
is
a
proteolytic
enzyme
with
various
pharmacological
properties,
such
as
antibacterial,
antioxidant,
anti-inflammatory,
anticancer,
and
anti-angiogenic
properties.
However,
due
to
its
low
solubility
bioavailability,
absorption
low,
so
delivery
mechanism
needed
achieve
the
desired
therapeutic
effects.
was
chemically
synthesized
loaded
onto
gold
nanoparticles
(AuNPs).
Different
methods
techniques
were
used
for
detection
characterization,
including
color-change
detection,
UV
spectroscopy,
XRD,
SEM,
TEM,
FTIR.
The
in
vitro
antioxidant
activity
detected
using
DPPH
assays,
wound-healing
investigated
mice.
current
study
revealed
that
formulated
AuNPs-Br
showed
effective
strongest
demonstrated
by
histopathological
vivo
studies,
