Immobilization of Bromelain on Gold Nanoparticles for Comprehensive Detection of Their Antioxidant, Anti-Angiogenic, and Wound-Healing Potentials DOI Creative Commons

Amal Ahmed Ausaj,

Hanady S. Al‐Shmgani, Wijdan Basheer Abed

и другие.

Inorganics, Год журнала: 2024, Номер 12(12), С. 325 - 325

Опубликована: Дек. 13, 2024

Bromelain (Br) is a proteolytic enzyme with various pharmacological properties, such as antibacterial, antioxidant, anti-inflammatory, anticancer, and anti-angiogenic properties. However, due to its low solubility bioavailability, absorption low, so delivery mechanism needed achieve the desired therapeutic effects. was chemically synthesized loaded onto gold nanoparticles (AuNPs). Different methods techniques were used for detection characterization, including color-change detection, UV spectroscopy, XRD, SEM, TEM, FTIR. The in vitro antioxidant activity detected using DPPH assays, wound-healing investigated mice. current study revealed that formulated AuNPs-Br showed effective strongest demonstrated by histopathological vivo studies,

Язык: Английский

Preparation, characterization and biomedical applications of electrospun cellulose acetate nanofiber dressing fabricated with silver and bioglass nanoparticles for efficient wound healing in streptozotocin induced diabetic rat DOI Creative Commons
Raghda Abdel‐Sattar, S. Sharaf, Abdullah Ahmed Gibriel

и другие.

Journal of Engineered Fibers and Fabrics, Год журнала: 2024, Номер 19

Опубликована: Янв. 1, 2024

Diabetic wound healing remains a significant challenge due to impaired and delayed processes. Recently, nanoscaffold dressings with their intricate architectures gained remarkable attention in regenerative medicine. Herein, electrospun cellulose acetate (CA) nanofiber incorporated various concentrations of bioglass nanoparticles (BGNPs) silver (AgNPs) were prepared as novel nanocomposites for possible diabetic healing. The physico-chemically characterized using scan electron microscopy (SEM), Fourier Transform Infra-Red Spectroscopy (FTIR), Energy-dispersive X-ray spectroscopy (EDX) Thermogravimetric analysis (TGA). antimicrobial activities the firstly evaluated in-vitro then in-vivo against streptozotocin-induced rats. FTIR EDX elemental analyses confirmed chemical structural composition CA/BGNPs/AgNPs dressings. SEM revealed uniform, smooth continuous (40–180 nm diameter) that showed higher thermal stability indicated by TGA analysis. 3% BGNPs 5% AgNPs loaded CA nanofibers maximal activity specifically gram positive Staphylococcus aureus (42 ± 1.9 mm) negative Escherichia coli (43 2.2 which are main two bacteria infecting wounds. In vivo study acceleration process combination efficient closure Day 6 without induction skin irritation. Therefore, newly designed dressing hold promising potential management

Язык: Английский

Процитировано

0

Immobilization of Bromelain on Gold Nanoparticles for Comprehensive Detection of Their Antioxidant, Anti-Angiogenic, and Wound-Healing Potentials DOI Creative Commons

Amal Ahmed Ausaj,

Hanady S. Al‐Shmgani, Wijdan Basheer Abed

и другие.

Inorganics, Год журнала: 2024, Номер 12(12), С. 325 - 325

Опубликована: Дек. 13, 2024

Bromelain (Br) is a proteolytic enzyme with various pharmacological properties, such as antibacterial, antioxidant, anti-inflammatory, anticancer, and anti-angiogenic properties. However, due to its low solubility bioavailability, absorption low, so delivery mechanism needed achieve the desired therapeutic effects. was chemically synthesized loaded onto gold nanoparticles (AuNPs). Different methods techniques were used for detection characterization, including color-change detection, UV spectroscopy, XRD, SEM, TEM, FTIR. The in vitro antioxidant activity detected using DPPH assays, wound-healing investigated mice. current study revealed that formulated AuNPs-Br showed effective strongest demonstrated by histopathological vivo studies,

Язык: Английский

Процитировано

0