Springer eBooks, Год журнала: 2024, Номер unknown, С. 21 - 34
Опубликована: Янв. 1, 2024
Язык: Английский
International Journal of Biological Sciences, Год журнала: 2021, Номер 18(2), С. 459 - 472
Опубликована: Дек. 15, 2021
The COVID-19 outbreak is emerging as a significant public health challenge. Excessive production of proinflammatory cytokines, also known cytokine storm, severe clinical syndrome to develop complication infectious or inflammatory diseases. Clinical evidence suggests that the occurrence storm in acute respiratory secondary coronavirus 2 (SARS-CoV-2) infection closely associated with rapid deterioration and high mortality cases. In this review, we aim summarize mechanism SARS-CoV-2 subsequent immunological events related excessive responses ACE2-AngII signaling. An overview diagnosis an update on current therapeutic regimens vaccinations provided.
Язык: Английский
Процитировано
115
ACS Nano, Год журнала: 2023, Номер 17(14), С. 13147 - 13157
Опубликована: Июль 7, 2023
Despite the worldwide success of mRNA-LNP Covid-19 vaccines, nanoscale structures these formulations are still poorly understood. To fill this gap, we used a combination atomic force microscopy (AFM), dynamic light scattering (DLS), transmission electron (TEM), cryogenic (cryo-TEM), and determination intra-LNP pH gradient to analyze nanoparticles (NPs) in BNT162b2 (Comirnaty), comparing it with well-characterized PEGylated liposomal doxorubicin (Doxil). Comirnaty NPs had similar size envelope lipid composition Doxil; however, unlike Doxil liposomes, wherein stable ammonium enables accumulation 14C-methylamine intraliposomal aqueous phase, LNPs lack such spite fact that 4, at which prepared, is raised 7.2 after loading mRNA. Mechanical manipulation AFM revealed soft, compliant structures. The sawtooth-like transitions seen during cantilever retraction imply molecular strands, corresponding mRNA, can be pulled out NPs, process accompanied by stepwise rupture mRNA-lipid bonds. Unlike Doxil, cryo-TEM granular, solid core enclosed mono- bilipid layers. Negative staining TEM shows 2-5 nm electron-dense spots LNP's interior aligned into strings, semicircles, or labyrinth-like networks, may cross-link-stabilized RNA fragments. neutral questions dominance ionic interactions holding together scaffold, raising possibility hydrogen bonding between mRNA lipids. Such interaction, described previously for another mRNA/lipid complex, consistent steric structure ionizable Comirnaty, ALC-0315, displaying free ═O -OH groups. It hypothesized latter groups get positions enable nitrogenous bases These structural features important vaccine's activities vivo.
Язык: Английский
Процитировано
51
International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1098 - 1098
Опубликована: Янв. 27, 2025
This article reviews the synergistic effects of antioxidant-enriched functional foods and exercise in improving metabolic health, focusing on underlying molecular mechanisms. The review incorporates evidence from PubMed, SCOPUS, Web Science, PsycINFO, reference lists relevant up to 20 December 2024, highlighting central role Nrf2 pathway. As a critical regulator oxidative stress adaptation, mediates benefits these interventions. presents an innovative approach understanding regulation inflammation, its potential prevention treatment various diseases, including cancer, neurodegenerative disorders, cardiovascular pulmonary diabetes, inflammatory conditions, ageing, infections such as COVID-19. novelty this study is investigate bioactive compounds found (such polyphenols, flavonoids, vitamins) exercise-induced activation combined reveals their improve insulin sensitivity lipid metabolism reduce offering promising strategy for management chronic diseases. However, there are significant gaps current research, particularly regarding mechanisms interaction between diet, physical activity, activation, well long-term different populations, those with In addition, interactions other signalling pathways, AMPK, NF-κB, PI3K/Akt, collective contributions health explored. Furthermore, novel biomarkers presented assess impact strategies, NAD+/NADH ratio, GSH markers mitochondrial health. findings provide valuable insights into how integration antioxidant-rich diet regular can by activating related pathways represent strategies disorders. Further studies needed fully understand therapeutic interventions diseases stress, disease, cancer.
Язык: Английский
Процитировано
4
International Immunopharmacology, Год журнала: 2021, Номер 100, С. 108162 - 108162
Опубликована: Сен. 17, 2021
Язык: Английский
Процитировано
88
International Journal of Biological Sciences, Год журнала: 2022, Номер 18(2), С. 889 - 900
Опубликована: Янв. 1, 2022
Vaccines are proving to be highly effective in controlling hospitalization and deaths associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, as shown by clinical trials real-world evidence. However, a deadly second wave of disease 2019 (COVID-19), infected SARS-CoV-2 variants, especially the Delta (B.1.617.2) variant, an increased number post-vaccination breakthrough infections were reported world recently. Actually, variant not only resulted surge vaccine which was accompanied high viral load transmissibility, but also challenged development vaccines. Therefore, biological characteristics epidemiological profile current status mechanism discussed this article. In addition, significant role spike (S) protein immune escape highlighted particular, we further key points on future research development, hoping make contribution early, accurate rapid control COVID-19 epidemic.
Язык: Английский
Процитировано
61
Cell Reports Medicine, Год журнала: 2023, Номер 4(2), С. 100918 - 100918
Опубликована: Янв. 12, 2023
With the widespread vaccinations against coronavirus disease 2019 (COVID-19), we are witnessing gradually waning neutralizing antibodies and increasing cases of breakthrough infections, necessitating development drugs aside from vaccines, particularly ones that can be administered outside hospitals. Here, present two cross-reactive nanobodies (R14 S43) their multivalent derivatives, including decameric (fused to immunoglobulin M [IgM] Fc) maintain potent activity severe acute respiratory syndrome 2 (SARS-CoV-2) after aerosolization display not only pan-SARS-CoV-2 but also varied pan-sarbecovirus activities. Through administration mice, monovalent R14 significantly reduce lung viral RNAs at low dose pre- post-exposure protection. Furthermore, structural studies reveal mechanisms S43 multiple inhibition effects derivatives exert. Our work demonstrates promising convenient drug candidates via SARS-CoV-2 infection, which contribute containing COVID-19 pandemic.
Язык: Английский
Процитировано
37
Biomedicines, Год журнала: 2023, Номер 11(2), С. 451 - 451
Опубликована: Фев. 3, 2023
The SARS-CoV-2 (severe acute respiratory syndrome coronavirus responsible for the COVID-19 disease) uses Spike proteins of its envelope infecting target cells expressing on membrane angiotensin converting enzyme 2 (ACE2) that acts as a receptor. To control pandemic, genetically engineered vaccines have been designed inducing neutralizing antibodies against proteins. These do not act like traditional protein-based vaccines, they deliver message in form mRNA or DNA to host then produce and expose protein (from which it can be shed soluble form) alert immune system. Mass vaccination has brought light various adverse effects associated with these based mainly affecting circulatory cardiovascular ACE2 is present membrane-bound several cell types, including mucosa upper gastrointestinal tracts, endothelium, platelets, plasma. converts vasoconstrictor II into peptides vasodilator properties. Here we review pathways immunization molecular mechanisms through protein, either from encoded by mRNA-based interferes Renin-Angiotensin-System governed ACE2, thus altering homeostasis circulation Understanding interactions consequent impact system will direct diagnosis therapy vaccine-related provide information development personalized considers pathophysiological conditions predisposing such events.
Язык: Английский
Процитировано
31
The Lancet Regional Health - Western Pacific, Год журнала: 2023, Номер 38, С. 100835 - 100835
Опубликована: Июль 11, 2023
SIM0417 (SSD8432) is an orally administered coronavirus main proteinase (3CL
Язык: Английский
Процитировано
29
International Journal of Biological Macromolecules, Год журнала: 2025, Номер 295, С. 139532 - 139532
Опубликована: Янв. 5, 2025
Язык: Английский
Процитировано
2
Heart Lung and Circulation, Год журнала: 2021, Номер 30(10), С. 1425 - 1429
Опубликована: Июль 31, 2021
The impact of the global health crisis due to virus Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2)—the causative pathogen coronavirus disease 2019 (COVID-19)—has begun alter with timely development, approval and administration vaccines [[1]Forchette L. Sebastian W. Liu T. A comprehensive review COVID-19 virology, vaccines, variants, therapeutics.https://doi.org/10.1007/s11596-021-2395-1Google Scholar]. Although SARS-CoV-2 infection primarily targets respiratory system [2Canatan D. Vives Corrons J.L. De Sanctis V. multifacets in adult patients: a concise clinical on pulmonary extrapulmonary manifestations for healthcare physicians.Acta Biomed. 2020; 91: e2020173PubMed Google Scholar, 3Triposkiadis F. Starling R.C. Xanthopoulos A. Butler J. Boudoulas H. counter regulatory axis lung renin-angiotensin severe COVID-19: pathophysiology implications.Heart Lung Circ. 2021 Jun; 30: 786-794Abstract Full Text PDF PubMed Scopus (12) 4Habashi N.M. Camporota Gatto L.A. Nieman G. Functional SARS-CoV-2-induced acute injury implications.J Appl Physiol (1985). 2021; 130: 877-891Crossref 5Ambardar S.R. Hightower S.L. Huprikar N.A. Chung K.K. Singhal Collen J.F. Post-COVID-19 fibrosis: novel sequelae current pandemic.J Clin Med. 10: 2452Crossref (69) 6Kvietys P.R. Fakhoury H.M.A. Kadan S. Yaqinuddin Al-Mutairy E. Al-Kattan K. lung-centric immunothrombosis.Front Cell Infect Microbiol. 11: 679878Crossref (16) Scholar], it is now recognised that its are systemic [7Satsangi Gupta N. Kodan P. Current new drugs treatment effects liver.J Transl Hepatol. 9: 436-446PubMed 8Ruscitti Conforti Cipriani Giacomelli R. Tasso M. Costa et al.Pathogenic implications, incidence, outcomes autoimmune inflammatory joint diseases autoinflammatory disorders.Adv Rheumatol. 61: 45Crossref (8) 9Zacharias Dubey Koduri D'Cruz Rheumatological complications Covid 19.https://doi.org/10.1016/j.autrev.2021.102883Google 10Cao T.T. Zhang G.Q. Pellegrini Zhao Q. Li Luo L.J. al.COVID-19 digestive system.World J Gastroenterol. 27: 3502-3515Crossref 11Sepehrinezhad Gorji Sahab Negah may trigger inflammasome pyroptosis central nervous system: mechanistic view neurotropism.Inflammopharmacology. 29: 1049-1059Crossref 12Afshar Z.M. Babazadeh Hasanpour Barary Sayad B. Janbakhsh al.Dermatological associated knowledge.https://doi.org/10.1002/jmv.27187Google also affecting cardiovascular adults children [13Smadja D.M. Mentzer S.J. Fontenay Laffan M.A. Ackermann Helms vascular hemopathy: insight aspects.https://doi.org/10.1007/s10456-021-09805-6Google 14Barssoum Victor Salem Kumar Mubasher Hassib al.Echocardiography, ultrasound, cardiac magnetic resonance findings systematic review.https://doi.org/10.1111/echo.15152Google 15Farshidfar Koleini Ardehali Cardiovascular COVID-19.JCI Insight. 6: 148980Crossref (73) 16Chung M.K. Zidar D.A. Bristow M.R. Cameron Chan Harding III, C.V. disease: from bench bedside.Circ Res. 128: 1214-1236Crossref (204) 17Carrizales-Sepúlveda E.F. Vera-Pineda Flores-Ramírez Hernández-Guajardo Pérez-Contreras Lozano-Ibarra M.M. al.Echocardiographic review.Heart 1117-1129Abstract (24) 18Kawakami Sakamoto Kawai Gianatti Nasr al.Pathological evidence as cause myocarditis: JACC Review Topic Week.J Am Coll Cardiol. 77: 314-325Crossref (163) 19Sperotto Friedman K.G. Son M.B.F. VanderPluym C.J. Newburger J.W. Dionne Cardiac SARS-CoV-2-associated multisystem syndrome children: proposed approach.Eur Pediatr. 180: 307-322Crossref (240) 20Parato V.M. Notaristefani C. D'Agostino D'Emilio Colella Kadiyala al.COVID-19-related pericarditis pericardial clotting hallmark: two cases review.J Cardiovasc Echogr. 31: 1-5Crossref (3) variable severity long-term known include myocardial injury, arrhythmias, vasculitis endothelial dysfunction, thrombosis, fibrosis, myocarditis 21Bajaj Sinclair H.C. Patel Low Pericao Manisty al.Delayed-onset following COVID-19.Lancet Respir e32-e34Abstract (45) 22Volis I. Livneh Hussein Raz-Pasteur COVID-19-associated suspected etiology recurrent protracted fever an otherwise healthy adult.Am Med Sci. 361: 522-525Abstract (6) 23Paterson Ramanathan Aurora Bewick Chow C.-M. Clarke al.Long primer professionals, behalf CCS Rapid Response Team.https://doi.org/10.1016/j.cjca.2021.05.011Google cellular COVID-19, management previously subjects patients existing or other conditions remain under intense investigation particularly early pandemic, was identified risk factor increased mortality [23Paterson 24Silva Andrade Siqueira de Assis Soares W.R. Souza Rangel Santos N.O. Dos Freitas al.Long-COVID post-COVID complications: up-to-date their possible molecular mechanisms.Viruses. 13: 700Crossref (199) 25Ruan Yang Wang Jiang Song Clinical predictors based analysis data 150 Wuhan, China.Intensive Care 46: 846-848Crossref (3346) Viral infections common myocarditis, which usually presents hallmark infiltrate cell unrelated ischaemia, absence overt [[26]Piccirillo Watanabe Di Sciascio Diagnosis, prognosis myocarditis. narrative review.https://doi.org/10.1016/j.carpath.2021.107362Google Scholar,[27]Law Y.M. Lal A.K. Chen Čiháková Cooper Jr., L.T. Deshpande al.American Heart Association Pediatric Failure Transplantation Committee Council Lifelong Congenital Disease Health Young Stroke CouncilDiagnosis Scientific Statement American Association.https://doi.org/10.1161/CIR.0000000000001001Google In subjects, anti-viral vaccine-associated immune eosinophilic rare but has been reported smallpox vaccine seasonal influenza [28Eckart R.E. Love S.S. Atwood J.E. Arness Cassimatis D.C. Campbell C.L. al.Department Defense Smallpox Vaccination Evaluation TeamIncidence follow-up after vaccination.J 2004; 44: 201-205Crossref (150) 29Kuntz Crane Weinmann Naleway A.L. Vaccine Safety Datalink Investigator TeamMyocarditis live viral vaccinations adults.Vaccine. 2018; 36: 1524-1527Crossref (44) 30Cheng M.P. Kozoriz M.G. Ahmadi A.A. Kelsall Paquette Onrot J.M. Post-vaccination myositis male.Allergy Asthma Immunol. 2016; 12: 6https://doi.org/10.1186/s13223-016-0114-4Crossref (33) 31Kim Y.J. Bae J.I. Ryoo S.M. Kim W.Y. fulminant vaccination requiring extracorporeal membrane oxygenation.Acute Crit Care. 2019; 34: 165-169Crossref Not surprisingly, highly publicised adverse events immunisation have great concern public authorities world-wide, when death 'previously healthy' individuals. There considerable focus occurrence Thrombosis Thrombocytopenia (TTS), Guillain-Barré Capillary Leak receipt adenoviral vector made by AstraZeneca (Covishield/Vaxzevria), even though causal relationship each respective incident not consistently established these exclusive vaccine. However, past few months there growing international list reports incidence and/or within one week receiving second dose mRNA (Pfizer-BioNTech BNT162b2/Comirnaty Moderna mRNA-1273), more often males, mostly adolescents young [32Australian Federal Government, Department Health, Therapeutic Goods Administration weekly safety report - 15-07-2021 [cited July 15, 2021].https://www.tga.gov.au/periodic/covid-19-vaccine-weekly-safety-report-15-07-2021Google 33Government Israel, Ministry June 02, 2021Surveillance Myocarditis (Inflammation Muscle) Cases Between December 2020 May (Including).https://www.gov.il/en/departments/news/01062021-03Google 34Medicines Healthcare Products Regulatory Agency (MHRA)Coronavirus vaccine- summary Yellow Card reporting [Internet].https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine-adversereactions/coronavirus-vaccine-summary-of-yellow-card-reportingGoogle 35European Medicines Pharmacovigilance Risk Assessment Summary 7-10, 2021.https://www.ema.europa.eu/en/news/meeting-highlights-pharmacovigilance-risk-assessment-committee-prac-7-10-june-2021Google 36Public Canada. daily epidemiology update. Ottawa (ON): Government Canada; 12 13, 2021]. https://health-infobase.canada.ca/covid-19/epidemiological-summary-covid-19-cases.html AND updated https://health-infobase.canada.ca/covid-19/vaccine-safety/ 20, 2021].Google 37Center Control. United States America Human ServicesCOVID-19 Technical (VaST) Work Group Report, 28, 2021.https://www.cdc.gov/vaccines/acip/work-groups-vast/report-2021-06-28.htmlGoogle 38Gargano Wallace Hadler S.C. Langley Su J.R. Oster M.E. al.Use among recipients: Update advisory Immunization Practices States, 2021.MMWR Morb Mortal Wkly Rep. 70: 977-982Crossref (0) Australia, 11 2021, (TGA) received 50 out 288 total event 3.7 million doses Pfizer [[32]Australian These temporally myocarditis/pericarditis course being evaluated be overestimate incidence; however, if all confirmed likely complications, this represents 13.5 per administered. After long delays availability rate finally begin ramp up over next months, TGA monitoring clinician vigilance will very important, consideration experience North Europe large populations where most advanced. Below, we draw attention brief summaries post-COVID-19 accounts UK, Europe, Canada, USA. At time writing report, monitoring, confirmation, patient exploring progress between governing agencies manufacturers. adjustment product information statements already recommended communicated care professionals. One earliest Israel April detailed, June, 62 5 vaccinated exclusively (an 12.4 patients). Notably, were predominantly younger than 30 years age, mainly male, had preceding 3 days. Importantly, well although 60 recovered less week, 2 deaths (one male aged 35 female 22 [[33]Government Against background considerations whether vaccinate (<12 years) against dosing regimen closely studied. UK 7 19.7 first about 11.6 Pfizer/BioNTech plus 1.1 administered [[34]Medicines As part open 'Yellow Card' reporting, (Department Social Care) listed (81 63 pericarditis), (9 9 pericarditis, 1 endocarditis), 5.0 doses. Of interest that, (adenoviral vector; vaccine), (107), 24.7 22.3 doses). European Agency, end cited approximately 160 Pfizer, 19 Moderna, 40 Janssen [[35]European EudraVigilance exposures (122 cases), (16 (38 cases). Post-vaccine (126 (18), (47) (1). This represented low 2.0 1.6 vaccines. Public Canada (PHAC), 41.5 163 'myocarditis/pericarditis' (median 39 years; range, 15–86) [[36]Public breakdown is: 111 Pfizer-BioNTech, AstraZeneca; case unspecified. 3.9 timing post-vaccination onset symptoms ranged hours 92 52 females 49 59 males 38 15–82). Interestingly, 67 occurred dose, 26 dose; and, 18 cases, no number specified. Detailed regard association link data. US Centers Control Prevention (CDC) mid-June 1,226 (Pfizer 29 2020–11 2021) 296 [[37]Center Scholar,[38]Gargano 4.1 median age (range, 12–94 symptom days 0–179), important note half old, two-thirds 75% Consequently, CDC physicians cardiologists 484 years, 323 individuals strictly met definitions Dallas Criteria Lake Louise myopericarditis [[38]Gargano 12–29 at 0–40 days), 92% 96% promptly hospitalised. Most managed through mild courses resolved, subsequent hospital discharge; deaths. mounting cohort studies date provide detailed into demographics, presentation, diagnosis, management, outcome [39Kim H.W. Jenista E.R. Wendell Azevedo C.F. M.J. Darty S.N. al.Patients vaccination.https://doi.org/10.1001/jamacardio.2021.2828Google 40Park Brekke D.R. Bratincsak Self-limited presenting chest pain ST segment elevation BNT162b2 vaccine.https://doi.org/10.1017/S1047951121002547Google 41Muthukumar Narasimhan Q.Z. Mahimainathan Hitto Fuda al.In depth evaluation presumed vaccine.https://doi.org/10.1161/CIRCULATIONAHA.121.056038Google 42D'Angelo Cattafi Carerj M.L. Booz Ascenti Cicero al.Myocarditis vaccination: vaccine-induced reaction?.https://doi.org/10.1016/j.cjca.2021.05.010Google 43Montgomery Ryan Engler Hoffman McClenathan Collins immunization members Military.https://doi.org/10.1001/jamacardio.2021.2833Google Montgomery al. [[43]Montgomery Scholar] larger retrospective series: 23 treated January (Pfizer, n=7 cases; n=16 All military staff high level fitness health. During 2.8 Military Service. markedly elevated troponin levels, consistent indications infection, conditions, ischaemic disease; however only eight examined imaging (MRI) phase illness, thus clinically confirming brief, rapid recovery patients. feature 44Schauer Buddhe Colyer Sagiv Law Y. Chikkabyrappa al.Myopericarditis adolescents.https://doi.org/10.1016/j.jpeds.2021.06.083Google general similarity condition, outcomes. highlight importance decision making MRI assisting excluding confounding abnormalities. Recently published & Circulation [[45]Berto M.B. Spano Wagner Bernhard Häner Huber A.T. al.Takotsubo cardiomyopathy Covid-19 vaccination.https://doi.org/10.1016/j.hlc.2021.06.521Google Berto al., Universitätsklinik für Kardiologie Inselspital, Bern, Switzerland, present Takotsubo 63-year-old day (mRNA-1273) vaccination. far aware, association, [[46]Singh Marinelli Horowitz J.D. anti-influenza catecholaminergic system.Am Emerg 2013; 1627.e1-1627.e4Abstract (20) case, provided valuable confirmative diagnostic support reinforces need characterise specific cardiomyopathic features subtype. 'stress'-associated cardiomyopathy, excess catecholamine-mediated stunning further inflammation inform medical dysfunction. fatality rates rise those 70 comorbidities, advantages advanced appreciated during pandemic. contrast, relatively lower SARS-CoV-2–related symptomatic disease, hospitalisation, intensive care, death, reticence limited groups. reinforced predominance featuring asymptomatic mild, upper tract resolves Case low, pre-existing life-threatening [[47]Tsabouri Makis Kosmeri Siomou factors Coronavirus 2019: literature review.Pediatr Am. 68: 321-338Abstract (89) greatly concerning complication children, 2-4 weeks emergence hyper-inflammation condition similar toxic circulatory shock Kawasaki disease—Paediatric Multisystem Inflammatory (PIMS-TS), Children (MIS-C). Presentation involves fever, markers shock, renal coronary artery aneurysm, urgent Given remaining prevalence community spread American, European, extend use Pfizer-BioNTech 12-15 recent trial randomised, placebo-controlled, observer-blinded, Phase (of 1–2–3 trial) assessing safety, immunogenicity, efficacy 2,260 (aged 12–15 16–25 demonstrated effective response 100% [[48]Frenck R.W. Klein N.P. Kitchin Gurtman Absalon Lockhart al.C4591001 Trial GroupSafety, adolescents.N Engl 385: 239-250Crossref (609) No vaccine-related serious cohorts. trials currently come completion greater confidence emphasis adolescents, especially production levels augment sufficiently meet demand proportions complete across world—and many nations still process—there questions regarding aetiology underlying milder presently either investigated reported. While definitive diagnoses vital carefully distinguished rapidly resolvable versus aetiology, complex co-morbidities co-existent risk.
Язык: Английский
Процитировано
55