Plant Secondary Metabolites as Modulators of Mitochondrial Health: An Overview of Their Anti-Oxidant, Anti-Apoptotic, and Mitophagic Mechanisms
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(1), С. 380 - 380
Опубликована: Янв. 4, 2025
Plant
secondary
metabolites
(PSMs)
are
a
diverse
group
of
bioactive
compounds,
including
flavonoids,
polyphenols,
saponins,
and
terpenoids,
which
have
been
recognised
for
their
critical
role
in
modulating
cellular
functions.
This
review
provides
comprehensive
analysis
the
effects
PSMs
on
mitochondrial
health,
with
particular
emphasis
therapeutic
potential.
Emerging
evidence
shows
that
these
improve
function
by
reducing
oxidative
stress,
promoting
biogenesis,
regulating
key
processes
such
as
apoptosis
mitophagy.
Mitochondrial
dysfunction,
hallmark
many
pathologies,
neurodegenerative
disorders,
cardiovascular
diseases,
metabolic
syndrome,
has
shown
to
benefit
from
protective
PSMs.
Recent
studies
show
can
dynamics,
stabilise
membranes,
enhance
bioenergetics,
offering
significant
promise
prevention
treatment
mitochondrial-related
diseases.
The
molecular
mechanisms
underlying
effects,
modulation
signalling
pathways
direct
interactions
proteins,
discussed.
integration
into
strategies
is
highlighted
promising
avenue
improving
efficacy
while
minimising
side
commonly
associated
synthetic
drugs.
also
highlights
need
future
research
elucidate
specific
roles
individual
synergistic
within
complex
plant
matrices,
may
further
optimise
utility.
Overall,
this
work
valuable
insights
health
potential
natural
agents
targeting
dysfunction.
Язык: Английский
Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway
Cell Proliferation,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 18, 2025
ABSTRACT
As
maternal
age
increases,
the
decline
in
oocyte
quality
emerges
as
a
critical
factor
contributing
to
reduced
reproductive
capacity,
highlighting
urgent
need
for
effective
strategies
combat
aging.
This
study
investigated
protective
effects
and
underlying
mechanisms
of
Echinacoside
(ECH)
on
aging
oocytes.
ECH
significantly
improved
cytoskeletal
stability
chromosomal
integrity,
demonstrated
by
restored
spindle
morphology
reinforced
F‐actin
structures,
essential
meiotic
progression.
It
also
preserved
mitochondrial
function
restoring
membrane
potential
dynamics,
reducing
ROS
levels,
downregulating
DNA
damage
marker
γ‐H2AX,
thereby
alleviating
oxidative
stress
enhancing
genomic
stability.
Furthermore,
promoted
cellular
homeostasis
through
modulation
lipid
metabolism,
autophagy
lysosomal
function.
Transcriptomic
analyses
identified
GJA1
pivotal
mediator
ECH's
effects,
validated
molecular
docking
bio‐layer
interferometry.
Functional
studies
showed
that
inhibiting
ability
enhance
first
polar
body
extrusion
rates,
antioxidant
validating
role
GJA1/SIRT1
pathway
combating
provides
novel
insights
into
rejuvenation
highlights
promising
therapeutic
candidate
addressing
age‐related
challenges.
Язык: Английский