Diffusion tensor imaging changes along the perivascular spaces may serve as a prognostic factor for high-grade glioma
European Journal of Radiology,
Год журнала:
2025,
Номер
184, С. 111993 - 111993
Опубликована: Фев. 9, 2025
Язык: Английский
Glymphatic system dysfunction in cerebral infarction: advances and perspectives based on DTI-derived ALPS measures
American Journal of Translational Research,
Год журнала:
2025,
Номер
17(3), С. 1630 - 1642
Опубликована: Янв. 1, 2025
The
glymphatic
pathway
plays
a
crucial
role
in
the
clearance
of
metabolic
byproducts
and
solutes
from
cerebral
tissue.
Dysfunction
has
been
associated
with
various
neurological
disorders,
including
ischemic
stroke.
Diffusion
tensor
imaging
(DTI)
derived
Analysis
aLong
Perivascular
Space
(ALPS)
have
emerged
as
promising
tools
for
evaluating
function.
This
review
aims
to
summarize
current
evidence
on
use
DTI-derived
ALPS
measures
assessing
dysfunction
stroke
patients,
explore
their
potential
implications
diagnosis,
prognostication,
treatment
monitoring
this
patient
population.
Язык: Английский
Influence of orientation, size and shape of the region of interest in diffusion MRI along perivascular spaces index
Magnetic Resonance Materials in Physics Biology and Medicine,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 11, 2025
Abstract
Objective
Diffusion-tensor
imaging
(DTI)
and
diffusion-weighted
(DWI)
along
perivascular
spaces
(ALPS)
index
have
been
proposed
as
noninvasive
techniques
to
indirectly
evaluate
the
glymphatic
system
function.
However,
these
are
sensitive
examination
parameters,
limiting
inter-study
comparability.
The
definition
of
region
interest
(ROI)
has
identified
primary
weakness
ALPS
method.
Therefore,
we
aimed
determine
which
ROI
characteristics
would
best
promote
consistent
analysis.
Methods
We
examined
13
healthy
volunteers
using
DTI
DWI
calculate
index,
compared
determined
correlations
among
11
different
configurations,
tested
inter-method
reliability.
Results
found
significant
differences
between
configurations
in
calculation.
Considering
reliability,
a
squared
is
most
suitable.
ICC
showed
good-to-excellent
agreement
(mean
=
0.83).
did
not
find
differences.
Conclusion
It
important
standardize
for
Язык: Английский
Analysis of the glymphatic system function in high-grade glioma patients using diffusion tensor imaging along perivascular spaces
BMC Neurology,
Год журнала:
2025,
Номер
25(1)
Опубликована: Апрель 25, 2025
This
study
seeks
to
determine
if
patients
with
high-grade
glioma
(HGG)
demonstrate
glymphatic
system
(GS)
impairments
using
Diffusion
Tensor
Imaging
Along
Perivascular
Spaces
(DTI-ALPS).
Additionally,
it
aims
examine
the
factors
affecting
GS
performance
and
their
implications
for
HGG
prognosis.
The
enrolled
fifty
alongside
age-
sex-matched
healthy
individuals.
Each
participant
underwent
diffusion
tensor
imaging
a
Philips
3.0T
MRI
scanner
assess
compute
ALPS
index
within
perivascular
spaces.
Variables
such
as
gender,
grade,
location,
volume,
peritumoral
edema
mass-edema
(peritumoral
volume/tumor
volume)
were
recorded.
Student's
t-test
rank
sum
test
compared
indices
between
controls
evaluate
hemispheric
differences.
Linear
multivariate
Cox
regression
analyses
utilized
discern
influencing
establish
independent
prognostic
markers
HGG,
respectively.
in
both
hemispheres
significantly
lower
patients,
ipsilateral
hemisphere
exhibiting
further
reduced
levels
than
contralateral
(P
<
0.001).
In
comparisons
involving
tumor
volumes,
no
significant
variations
observed
harboring
larger
tumors
=
0.079)
or
lesser
volumes
0.24).
A
decrease
postoperative
preoperative
figures
was
noted
Univariate
linear
indicated
negative
relationship
volume
0.0392).
Kaplan-Meier
analysis
demonstrated
shorter
survival
times
indices.
Moreover,
highlighted
grade
(HR
1.548,
P
0.023)
0.040,
0.003)
crucial
indicators.
there
is
impaired
function
of
brain.
tumor-side
associated
tumor-associated
edema.
Following
surgery,
damage
brain
patients.
Poor
correlated
worse
prognosis
Язык: Английский
Clinical reflections of the glymphatic system and neurodegenerative diseases
Journal of Medical Topics and Updates,
Год журнала:
2025,
Номер
4(1), С. 16 - 22
Опубликована: Апрель 30, 2025
Objective:
The
brain
is
one
of
the
main
elements
central
nervous
system
and
protected
within
bone
structure
formed
by
skull
bones.
endocrine
play
a
fundamental
role
in
maintaining
homeostasis.
brain;
How
are
wastes
that
occur
as
result
these
biochemical
events
eliminated
when
it
has
such
basic
important
tasks?
Until
2012,
was
thought
there
no
lymphatic
brain.
Our
aim
with
this
literature
review
to
make
easier
find
answers
questions.
Materials
Methods:
For
research,
existing
systematically
reviewed
terms
glymphatic
system.
Results:
brain’s
waste
clearance
mechanism.
Many
anatomical
structures
involved
Astrocytes
aquaporin-4
channels
were
most
notable
these.
Conclusions:
clearing
mechanism
many
function
mechanisms.
Although
been
subject
current
research
human
animal
experiments
recent
years,
still
an
area
preserves
its
mystery.
remains
mysterious.
Disruption
closely
associated
neurodegenerative
diseases.
We
believe
system,
which
plays
vital
health,
should
be
more
scientific
clarify
functioning
Язык: Английский
Cerebral small vessel disease: The impact of glymphopathy and sleep disorders
Journal of Cerebral Blood Flow & Metabolism,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 5, 2025
The
glymphatic
system,
a
vital
brain
perivascular
network
for
waste
clearance,
hinges
on
the
functionality
of
aquaporin
4
(AQP4)
water
channel.
Alarmingly,
AQP4
single
nucleotide
polymorphisms
(SNPs)
are
linked
to
impaired
or
glymphopathy,
which
contributes
sleep
disturbances
and
various
age-related
neurodegenerative
diseases.
Despite
critical
role
glymphopathy
in
cerebral
small
vessel
disease
(CSVD)
–
silent
precursor
disorders
their
interplay
remains
underexplored.
CSVD
is
major
cause
stroke
dementia,
yet
its
pathogenesis
not
fully
understood.
Emerging
evidence
implicates
as
pivotal
factors
CSVD,
exacerbating
condition
by
hindering
removal
compromising
blood-brain
barrier
(BBB)
integrity.
Advanced
imaging
techniques
promise
enhance
diagnosis
monitoring,
while
lifestyle
modifications
personalised
medicine
present
promising
treatment
avenues.
This
narrative
review
underscores
need
multidisciplinary
approach
understanding
CSVD.
By
exploring
roles,
emphasising
necessity
longitudinal
studies,
discussing
potential
therapeutic
interventions,
this
paper
aims
pave
way
new
research
directions
management.
Язык: Английский
The glymphatic system in oncology: from the perspective of a radiation oncologist
Journal of Radiation Research,
Год журнала:
2025,
Номер
unknown
Опубликована: Июнь 3, 2025
The
brain
and
spinal
cord,
which
constitute
the
central
nervous
system,
were
historically
considered
immune-privileged
sites,
as
it
was
believed
they
lacked
an
equivalent
to
systemic
lymphatic
system.
However,
in
2013,
a
pathway
facilitating
clearance
of
waste
products
through
parenchyma
via
perivascular
space
proposed,
garnering
attention
'glymphatic
system'.
Similar
glymphatic
system
plays
critical
role
immune
responses
has
been
implicated
not
only
Alzheimer's
disease
inflammatory
disorders
but
also
conditions
such
hydrocephalus
glaucoma,
are
associated
with
cerebrospinal
fluid
circulation
impairments.
Recent
studies
have
suggested
that
dysfunction
may
promote
progression
tumors
reduce
efficacy
pharmacological
therapies
targeting
tumors.
Radiotherapy
is
major
treatment
option
for
tumors;
however,
while
can
enhance
against
tumors,
suppress
these
at
same
time.
Additionally,
cranial
irradiation
impair
function
This
review
provides
overview
structure
functional
evaluation
methods
summarizes
effects
its
on
tumor
treatment,
explores
recent
findings
impact
radiation
therapy
functioning.
Lastly,
potential
strategies
account
their
Язык: Английский