Gastric cancer: a comprehensive review of current and future treatment strategies

Cancer and Metastasis Reviews, Год журнала: 2020, Номер 39(4), С. 1179 - 1203

Опубликована: Сен. 7, 2020

Язык: Английский

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Tumor-Associated Macrophages and Inflammatory Microenvironment in Gastric Cancer: Novel Translational Implications

International Journal of Molecular Sciences, Год журнала: 2021, Номер 22(8), С. 3805 - 3805

Опубликована: Апрель 7, 2021

Gastric cancer (GC) represents the fifth most frequently diagnosed worldwide, with a poor prognosis in patients advanced disease despite many improvements systemic treatments last decade. In fact, GC has shown resistance to several treatment options, and thus, notable efforts have been focused on research identification of novel therapeutic targets this setting. The tumor microenvironment (TME) emerged as potential target malignancies including GC, due its pivotal role progression drug resistance. Therefore, agents strategies targeting TME are currently under assessment both preclinical clinical studies. present study provides an overview available evidence inflammatory highlighting different types tumor-associated cells implications for future strategies.

Язык: Английский

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Recent Progress and Future Perspectives of Immunotherapy in Advanced Gastric Cancer

Frontiers in Immunology, Год журнала: 2022, Номер 13

Опубликована: Июль 1, 2022

As one of the most common forms solid tumours, gastric carcinoma has been revealed as third leading cause death worldwide. The symptom cancer is usually not obvious and thus difficult to detect at earlier stages. Therefore, already in advanced stage once detected patients, which a poor prognosis due ineffective therapies multiple resistance. Recent advance understanding microenvironment significantly promoted development immunotherapy for cancer. Immunotherapy can induce immune responses patients leads destruction cells. In comparison traditional therapy, demonstrated robust efficacy tolerable toxicity. this novel strategy treatment gain increasingly popularity. review, we summarize recent progress cancer, such check point inhibitors, adoptive cell VEGF vaccines CAR-T therapy. We highlight immunotherapies involved clinical applications discuss existing challenges current promising strategies overcome these limitations.

Язык: Английский

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Research progress on the immune microenvironment and immunotherapy in gastric cancer

Frontiers in Immunology, Год журнала: 2023, Номер 14

Опубликована: Ноя. 23, 2023

The tumor microenvironment, particularly the immune plays an indispensable role in malignant progression and metastasis of gastric cancer (GC). As our understanding GC microenvironment continues to evolve, we are gaining deeper insights into biological mechanisms at single-cell level. This, turn, has offered fresh perspectives on therapy. Encouragingly, there various monotherapy combination therapies use, such as checkpoint inhibitors, adoptive cell transfer therapy, chimeric antigen receptor T antibody-drug conjugates, vaccines. In this paper, review current research progress regarding summarize promising immunotherapy targeted therapies.

Язык: Английский

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Immunological Aspects of the Tumor Microenvironment and Epithelial-Mesenchymal Transition in Gastric Carcinogenesis

International Journal of Molecular Sciences, Год журнала: 2020, Номер 21(7), С. 2544 - 2544

Опубликована: Апрель 6, 2020

Infection with Helicobacter pylori, a Gram-negative, microaerophilic pathogen often results in gastric cancer subset of affected individuals. This explains why H. pylori is the only bacterium classified as class I carcinogen by World Health Organization. Several studies have pinpointed mechanisms which alters signaling pathways host cell to cause diseases. In this article, authors reviewed 234 conducted over span 18 years (2002–2020). The investigated various associated induction. For past 1.5 years, researchers discovered new contributing linked etiology. Alongside alteration using oncogenic CagA pathways, induce DNA damage and alter methylation means perturbing downstream signaling. Also, several are activated, resulting epithelial-to-mesenchymal transition (EMT), together induction proliferation survival. Studies shown that enhances carcinogenesis via multifactorial approach. What intriguing most targeted appear common forms cancer.

Язык: Английский

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Identification and characterization of CLEC11A and its derived immune signature in gastric cancer

Frontiers in Immunology, Год журнала: 2024, Номер 15

Опубликована: Янв. 29, 2024

Introduction C-type lectin domain family 11 member A (CLEC11A) was characterized as a growth factor that mainly regulates hematopoietic function and differentiation of bone cells. However, the involvement CLEC11A in gastric cancer (GC) is not well understood. Methods Transcriptomic data clinical information pertaining to GC were obtained analyzed from publicly available databases. The relationships between prognoses, genetic alterations, tumor microenvironment (TME), therapeutic responses patients by bioinformatics methods. CLEC11A-derived immune signature developed validated, its mutational landscapes, immunological characteristics drug sensitivities explored. nomogram established combining factors. expression carcinogenic effects verified qRT−PCR, cell migration, invasion, cycle analysis, vivo model analysis. Myeloid-derived suppressor cells (MDSCs), regulatory T (Tregs), M2 macrophages, samples extracted mice utilizing flow cytometry Results over-expressed GC, elevated indicated an unfavorable prognosis patients. involved genomic alterations associated with TME GC. Moreover, found reduce benefit immunotherapy according immunophenoscore (IPS) dysfunction, exclusion (TIDE). After validation, demonstrated consistent ability predict survival outcomes quantifies probability constructed improve accuracy prediction Using shRNA suppress led significant inhibitions progression, marked reduction growth. assay showed knock-down increased infiltration cytotoxic CD8+ helper CD4+ into tumors while decreasing percentage MDSCs, Tregs. Conclusion Collectively, our findings revealed could be prognostic biomarker might serve new option for clinicians formulate personalized treatment plans

Язык: Английский

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Gastric Cancer, Immunotherapy, and Nutrition: The Role of Microbiota

Pathogens, Год журнала: 2024, Номер 13(5), С. 357 - 357

Опубликована: Апрель 26, 2024

Immune checkpoint inhibitors (ICI) have revolutionized the treatment of gastric cancer (GC), which still represents third leading cause cancer-related death in Western countries. However, ICI outcomes vary between individuals and need to be optimized. Recent studies shown that gut microbiota could represent a key influencer immunotherapy responses. At same time, nutritional status diet GC patients are also predictive response survival outcomes. The objective this narrative review is gather recent findings about complex relationships oral, gastric, bacterial communities, dietary factors/nutritional parameters, Perigastric/gut compositions/functions their metabolites even overall survival. strong influence on composition consequences responses through impact muscle mass during immunotherapy. Future needed define more precisely factors, such as adequate daily intake prebiotics, counteract dysbiosis impaired status, improving clinical

Язык: Английский

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CD2AP shapes a stromal reduced tumor microenvironment and contributes to immunotherapy in gastric cancer

BMC Cancer, Год журнала: 2025, Номер 25(1)

Опубликована: Май 21, 2025

Gastric cancer (GC) ranks as the fifth most prevalent malignant tumor and stands fourth leading contributor to cancer-related fatalities on a global scale. The specific link between CD2 Associated Protein (CD2AP) expression microenvironment (TME) remains unclear, further exploration is needed understand its potential role in immune response target for immunotherapy GC. Utilizing RNA sequencing data acquired from Cancer Genome Atlas (TCGA) pan-cancer analysis, comprehensive evaluation was carried out determine pattern immunological involvement of CD2AP. Systematic association CD2AP with features within stomach adenocarcinoma (STAD) TME subsequently performed, encompassing factors like immunity cycles, checkpoints, immunomodulators, tumor-infiltrating cells (TIICs). We found that enhanced variety malignancies. contributes forming stromal reduced GC improve efficacy immunotherapy. It observed patients elevated levels CD2AP, along high scores their CD4, CD20, CD57 markers, tended experience favorable prognosis. Furthermore, an IRS constructed accurately assess prognosis STAD patients. Since associated formation STAD, can effect STAD. could emerge novel prognostic biomarker offering fresh avenue molecular targeted therapy.

Язык: Английский

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CD3D Is an Independent Prognostic Factor and Correlates With Immune Infiltration in Gastric Cancer

Frontiers in Oncology, Год журнала: 2022, Номер 12

Опубликована: Июнь 1, 2022

The protein encoded by CD3D is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and involved in development signal transduction. Previous studies have shown that associated with prognosis treatment response breast, colorectal, liver cancer. However, expression clinical significance gastric cancer are not clear. In this study, we collected 488 tissues 430 paired adjacent to perform tissue microarrays (TMAs). Then, immunohistochemical staining CD3D, CD3, CD4, CD8 PD-L1 was conducted investigate correlation between tumor infiltrating lymphocytes (TILs) PD-L1. results showed highly expressed compared paracancerous ( P <0.000). Univariate multivariate analyses an independent good prognostic factor for =0.004, HR=0.677, 95%CI: 0.510-0.898 univariate analyses; =0.046, HR=0.687, 0.474-0.994 analyses). addition, negatively correlated location, Borrmann type distant metastasis =0.012 location; =0.007 type; =0.027 metastasis). positively CD8, PD-L1, combination predicted best =0.043). summary, may play important regulatory role immune microenvironment serve as a potential indicator immunotherapy response.

Язык: Английский

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Prognostic Value of T-Cell Density in the Tumor Center and Outer Margins in Gastric Cancer

Modern Pathology, Год журнала: 2023, Номер 36(9), С. 100218 - 100218

Опубликована: Май 12, 2023

Tumor-infiltrating lymphocytes are associated with the survival of gastric cancer patients. T-cell densities in tumor and its periphery were previously identified as prognostic markers for resectable cancer. Immunohistochemistry 5 markers, CD3, CD45RO, CD8, FOXP3, granzyme B was performed on serial sections N = 251 surgical resection specimens patients treated surgery only D1/D2 trial. Positive T cells digitally quantified into tiles 0.25 mm2 across 3 regions: center (TC), inner invasive margin, outer margin (OIM). A classification regression tree model employed to identify optimal combination median per region cancer-specific (CSS) outcome. All statistical tests 2-sided. CD8OIM most dominant factor, followed by FOXP3TC, resulting a decision containing prognostically distinct subgroups high (Hi) or low (Lo) density markers: CD8OIMHi, CD8OIMLo/FOXP3TCHi, CD8OIMLo/FOXP3TCLo. In multivariable Cox analysis, which included pathological stages, Lauren histologic types, EBV status, microsatellite instability, type surgery, immune independent predictors CSS. CSS lower CD8OIMLo/FOXP3TCHi (HR: 5.02; 95% CI: 2.03-12.42) CD8OIMLo/FOXP3TCLo 7.99; 3.22-19.86), compared CD8OIMHi (P < .0001). The location both CD8+ FOXP3+ independently survival. FOXP3TC is promising stratification factor that should be validated studies.

Язык: Английский

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